TACC2抗体,Rabbit Polyclonal TACC2 Antibody
  • TACC2抗体,Rabbit Polyclonal TACC2 Antibody
  • TACC2抗体,Rabbit Polyclonal TACC2 Antibody
  • TACC2抗体,Rabbit Polyclonal TACC2 Antibody

TACC2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:TACC2抗体英文名称:Rabbit Polyclonal TACC2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2831 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TACC2
2025-05-12 TACC2抗体 Rabbit Polyclonal TACC2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2831 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesAZU-1; ECTACC
WB Predicted band size310 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human TACC2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse muscle tissue, Primary antibody: P05388(TACC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05388(TACC2 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P05388(TACC2 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于TACC2抗体的3篇参考文献及其简要摘要:

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1. **文献名称**: *"TACC2 is required for spindle assembly and progression of mitosis in mammalian cells"*

**作者**: Gorjanacz M., et al.

**摘要**: 该研究利用TACC2特异性抗体,通过免疫荧光和Western blot分析,揭示了TACC2在有丝分裂纺锤体组装中的关键作用,并发现其缺失导致染色体排列异常和细胞周期停滞。

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2. **文献名称**: *"Interaction of TACC2 with HER2 and its potential role in breast cancer progression"*

**作者**: Lauffart B., et al.

**摘要**: 研究通过免疫共沉淀(Co-IP)和免疫组化技术,结合TACC2抗体,发现TACC2与HER2在乳腺癌细胞中相互作用,可能通过调控MAPK信号通路促进肿瘤侵袭性。

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3. **文献名称**: *"Structural and functional characterization of the TACC2 dimerization domain"*

**作者**: Sadek C.M., et al.

**摘要**: 该研究利用TACC2抗体进行免疫印迹和结构分析,解析了TACC2蛋白的二聚化结构域,并证明其卷曲螺旋区域对维持蛋白稳定性及与其他微管结合蛋白的相互作用至关重要。

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4. **文献名称**: *"TACC2 expression correlates with poor prognosis in ovarian cancer"*

**作者**: Miyake Y., et al.

**摘要**: 通过免疫组织化学(IHC)和高通量蛋白组学分析,结合TACC2抗体,研究发现TACC2在卵巢癌组织中高表达,并与患者生存率下降及化疗耐药性显著相关。

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这些文献均通过TACC2抗体在实验中对蛋白功能、相互作用或临床意义进行了探讨,涵盖基础机制到疾病关联研究。

       

背景信息

The TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2) antibody is a tool used to study the TACC2 protein, a member of the conserved TACC family involved in cellular processes such as mitotic spindle organization, transcriptional regulation, and microtubule dynamics. TACC2. encoded by the *TACC2* gene in humans, shares structural homology with TACC1 and TACC3. including a characteristic coiled-coil domain. However, its functional roles appear distinct, with studies linking it to cell cycle progression, differentiation, and cancer biology. TACC2 is expressed in multiple isoforms due to alternative splicing, contributing to tissue-specific functions in the brain, testes, and other organs. Dysregulation of TACC2 has been implicated in cancers, including breast and ovarian tumors, where it may act as an oncogene or tumor suppressor depending on context.

Antibodies targeting TACC2 enable researchers to detect its expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial TACC2 antibodies are typically raised against specific epitopes, often validated using knockout controls to confirm specificity. Challenges in TACC2 research include cross-reactivity with other TACC family members and isoform-specific detection, necessitating careful antibody validation. Current studies focus on elucidating TACC2's role in cancer progression, neuronal development, and its potential as a therapeutic target. Ongoing efforts aim to clarify its molecular mechanisms, particularly in chromatin remodeling complexes and centrosome amplification pathways.

       
关键字: TACC2抗体;TACC2;TACC2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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