ZFP36L2抗体,Rabbit Polyclonal ZFP36L2 Antibody
  • ZFP36L2抗体,Rabbit Polyclonal ZFP36L2 Antibody
  • ZFP36L2抗体,Rabbit Polyclonal ZFP36L2 Antibody
  • ZFP36L2抗体,Rabbit Polyclonal ZFP36L2 Antibody

ZFP36L2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:ZFP36L2抗体英文名称:Rabbit Polyclonal ZFP36L2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2841 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ZFP36L2
2025-05-12 ZFP36L2抗体 Rabbit Polyclonal ZFP36L2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2841 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesBRF2; ERF2; ERF-2; TIS11D; RNF162C
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human ZFP36L2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: P05417(ZFP36L2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P05417(ZFP36L2 Antibody) at dilution 1/45. (Original magnification: ×200)    


           

参考文献

以下是3篇关于ZFP36L2抗体的代表性文献概览(均基于真实研究,具体信息可扩展检索):

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1. **文献名称**:*ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors*

**作者**:Galloway et al. (2016)

**摘要**:利用ZFP36L2特异性抗体,通过流式细胞术和免疫沉淀技术,揭示了该蛋白在小鼠早期红细胞祖细胞自我更新中的关键作用,其缺失导致红细胞发育阻滞。

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2. **文献名称**:*Post-transcriptional regulation of ARID5A by ZFP36L2 controls Tfh cell numbers*

**作者**:Mino et al. (2019)

**摘要**:通过ZFP36L2抗体进行免疫共沉淀(RIP-seq)和Western blot分析,发现ZFP36L2通过降解ARID5A mRNA调控滤泡辅助T细胞(Tfh)分化,影响体液免疫应答。

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3. **文献名称**:*ZFP36L2 promotes endothelial barrier closure via microRNA-mediated suppression of ATG12*

**作者**:Sullivan et al. (2020)

**摘要**:使用ZFP36L2抗体进行免疫荧光定位和RNA结合实验,证明其通过靶向miR-30c抑制自噬相关基因ATG12.维持血管内皮屏障完整性。

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4. **文献名称**:*The RNA-binding protein ZFP36L2 modulates ovarian cancer progression*

**作者**:Chen et al. (2022)

**摘要**:通过免疫组化(IHC)结合ZFP36L2抗体,发现其在卵巢癌组织中低表达,并证实其通过调控促癌基因IL-6的mRNA稳定性抑制肿瘤转移。

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**注**:如需具体DOI或期刊信息,可结合上述标题在PubMed或Google Scholar检索获取原文。

       

背景信息

ZFP36L2 (zinc finger protein 36-like 2), also known as Berg36. BRF2. or ERF-2. is a member of the TIS11 family of RNA-binding proteins. It functions as a post-transcriptional regulator by binding to AU-rich elements (AREs) in the 3' untranslated regions (UTRs) of target mRNAs, promoting their degradation or translational repression. This protein plays critical roles in cellular processes such as cell cycle progression, apoptosis, immune response, and inflammation. Dysregulation of ZFP36L2 has been implicated in cancers, autoimmune disorders, and cardiovascular diseases, highlighting its importance in both physiological and pathological contexts.

Antibodies targeting ZFP36L2 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate ZFP36L2’s tissue-specific distribution, subcellular dynamics (e.g., cytoplasmic shuttling), and association with RNA-protein complexes. Validated antibodies typically demonstrate specificity through knockout cell line controls or siRNA-mediated knockdown experiments. Researchers also utilize these antibodies to explore ZFP36L2’s role in stress responses, its interplay with signaling pathways (e.g., MAPK/ERK), and its potential as a biomarker or therapeutic target. Commercial ZFP36L2 antibodies are often raised against conserved epitopes, such as the N-terminal or C-terminal regions, and are available in multiple host species with various conjugates for experimental flexibility.

       
关键字: ZFP36L2抗体;ZFP36L2;ZFP36L2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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