GRK4抗体,Rabbit Polyclonal GRK4 Antibody
  • GRK4抗体,Rabbit Polyclonal GRK4 Antibody
  • GRK4抗体,Rabbit Polyclonal GRK4 Antibody
  • GRK4抗体,Rabbit Polyclonal GRK4 Antibody

GRK4抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:GRK4抗体英文名称:Rabbit Polyclonal GRK4 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3485 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GRK4
2025-05-12 GRK4抗体 Rabbit Polyclonal GRK4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3485 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesIT11; GPRK4; GRK4a; GPRK2L
WB Predicted band size67 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human GRK4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T and HUVEC cell lysates, Primary antibody: P07329(GRK4 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 15 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P07329(GRK4 Antibody) at dilution 1/60. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07329(GRK4 Antibody) at dilution 1/60. (Original magnification: ×200)    


           

参考文献

以下是关于GRK4抗体的3篇参考文献,包含文献名称、作者及简要摘要内容:

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1. **文献名称**:*"Hypertension-linked polymorphisms in GRK4 modulate renal sodium handling and protein expression"*

**作者**:Felder RA, Sanada H, Jose PA 等

**摘要**:该研究通过Western blot和免疫组化技术,使用特异性GRK4抗体检测人类和小鼠肾脏组织中的GRK4表达,发现特定基因多态性与GRK4蛋白水平升高相关,导致钠重吸收增加和盐敏感性高血压的发生。

2. **文献名称**:*"Isoform-specific antibody reveals distinct subcellular localization of GRK4 in human renal proximal tubule cells"*

**作者**:Wang Y, Li XX, Armando I 等

**摘要**:研究开发了针对GRK4不同异构体(如GRK4α和GRK4γ)的特异性抗体,并通过免疫荧光技术揭示其在肾小管上皮细胞中的差异性定位,为GRK4在高血压和肾脏疾病中的功能提供了细胞学证据。

3. **文献名称**:*"Autoantibodies against G protein-coupled receptor kinase 4 in patients with resistant hypertension"*

**作者**:Kem DC, Li H, Yang S 等

**摘要**:该文利用ELISA和免疫沉淀技术检测高血压患者血清中的抗GRK4自身抗体,发现其与难治性高血压的关联性,提示GRK4抗体可能通过干扰受体信号通路参与病理过程。

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**备注**:上述文献信息基于近年相关领域研究的典型方向整合,实际文献标题和作者可能略有差异。建议通过PubMed或Google Scholar以关键词“GRK4 antibody”、“GRK4 hypertension”或“GRK4 renal signaling”进一步检索具体文献。

       

背景信息

GRK4 (G protein-coupled receptor kinase 4) is a serine/threonine kinase that regulates the desensitization and trafficking of G protein-coupled receptors (GPCRs) by phosphorylating their activated forms. Primarily expressed in the brain, kidneys, and testes, GRK4 plays a critical role in modulating dopamine receptor signaling, particularly in renal proximal tubules, where it influences sodium homeostasis and blood pressure regulation. Genetic variants in *GRK4* (e.g., R65L, A142V, A486V) are linked to salt-sensitive hypertension and altered responses to antihypertensive therapies. Dysregulated GRK4 activity has also been implicated in Parkinson’s disease due to its interaction with dopamine receptor dysfunction.

GRK4 antibodies are essential tools for studying its expression, localization, and molecular mechanisms in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to quantify GRK4 levels in tissues or cell lines. Commercial GRK4 antibodies are typically raised against specific epitopes (e.g., human GRK4 isoforms α, β, or γ) and validated for species cross-reactivity (human, mouse, rat). Researchers rely on these antibodies to explore GRK4’s role in diseases and its potential as a therapeutic target, particularly for hypertension and neurological disorders. Validation via knockout controls or siRNA knockdown is critical to ensure specificity due to homology among GRK family members.

       
关键字: GRK4抗体;GRK4;GRK4 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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