SAR1B抗体,Rabbit Polyclonal SAR1B Antibody
  • SAR1B抗体,Rabbit Polyclonal SAR1B Antibody
  • SAR1B抗体,Rabbit Polyclonal SAR1B Antibody
  • SAR1B抗体,Rabbit Polyclonal SAR1B Antibody

SAR1B抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
QQ交谈 微信洽谈

产品详情

中文名称:SAR1B抗体英文名称:Rabbit Polyclonal SAR1B Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3380 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SAR1B
2025-05-12 SAR1B抗体 Rabbit Polyclonal SAR1B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3380 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesANDD; CMRD; GTBPB; SARA2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human SAR1B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07107(SAR1B Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P07107(SAR1B Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于SAR1B抗体的3篇参考文献示例及其摘要概述:

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1. **标题**:*"SAR1B GTPase mutations in chylomicron retention disease: Functional characterization and antibody-based detection"*

**作者**:Jones, M.K. et al. (2015)

**摘要**:研究分析了SAR1B基因突变导致乳糜微粒滞留病(CMRD)的分子机制,开发了特异性抗体用于Western blot和免疫荧光,证实突变导致内质网-高尔基体运输缺陷及脂蛋白分泌障碍。

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2. **标题**:*"Role of SAR1B in lipoprotein assembly: Insights from cellular models using CRISPR/Cas9 and antibody-mediated inhibition"*

**作者**:Santos, R. et al. (2016)

**摘要**:通过CRISPR/Cas9敲除SAR1B并结合特异性抗体阻断实验,揭示了SAR1B在载脂蛋白B-48脂化过程中的关键作用,证明其缺失导致乳糜微粒组装异常。

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3. **标题**:*"Immunohistochemical localization of SAR1B in intestinal biopsies: A diagnostic tool for CMRD"*

**作者**:Sane, A.T. et al. (2010)

**摘要**:开发了针对SAR1B的单克隆抗体,用于肠活检组织的免疫组化分析,发现CMRD患者中SAR1B蛋白表达显著降低,提出其作为该病的辅助诊断标志物。

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**备注**:以上文献信息为示例性质,实际引用时建议通过PubMed或Google Scholar核实具体文章是否存在及细节准确性。

       

背景信息

The SAR1B antibody is a crucial tool for studying the SAR1B protein, a member of the SAR1 GTPase family involved in intracellular vesicular transport. SAR1B, a key component of the COPII (coat protein complex II) machinery, facilitates the budding of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus. This process is essential for the secretion of proteins and lipids, including apolipoprotein B (apoB)-containing lipoproteins. Mutations in the SAR1B gene are linked to congenital disorders such as chylomicron retention disease (CMRD), a rare autosomal recessive condition characterized by lipid malabsorption, fat-soluble vitamin deficiencies, and failure to thrive in infants.

SAR1B antibodies are widely used in research to investigate the protein’s expression, localization, and function in cellular trafficking pathways. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess SAR1B levels in tissues or cultured cells, particularly in studies of lipid metabolism and ER-Golgi transport dynamics. Additionally, these antibodies aid in diagnosing genetic disorders by detecting aberrant SAR1B expression in patient-derived samples. By elucidating SAR1B’s role in COPII assembly and cargo selection, researchers gain insights into broader mechanisms of cellular secretion and related pathologies, including metabolic syndromes and neurodegenerative diseases. The antibody’s specificity and reliability make it indispensable for both basic research and clinical applications.

       
关键字: SAR1B抗体;SAR1B;SAR1B Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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