GADD45B抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08352(GADD45B Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08352(GADD45B Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The GADD45B (Growth Arrest and DNA Damage-Inducible Beta) antibody is a crucial tool for studying the GADD45B protein, a member of the GADD45 family involved in cellular stress responses. GADD45B is induced by various stressors, including DNA damage, oxidative stress, and cytokine signaling, and plays roles in cell cycle arrest, apoptosis, DNA repair, and inflammation. It interacts with key signaling pathways such as p38 MAPK and NF-κB, influencing processes like tumor suppression, immune regulation, and tissue homeostasis.

Antibodies targeting GADD45B enable researchers to detect and quantify its expression in cells and tissues using techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are essential for exploring GADD45B's involvement in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. For instance, altered GADD45B expression has been linked to tumor progression, neuronal survival, and inflammatory responses.

Validated GADD45B antibodies typically undergo specificity testing (e.g., knockout controls) to ensure accurate detection. Researchers prioritize antibodies with high sensitivity and cross-reactivity across species (e.g., human, mouse, rat) for translational studies. Commercial antibodies often include validation data in datasheets, supporting their reliability in experimental models. Understanding GADD45B's regulation and function via these antibodies provides insights into stress adaptation mechanisms and potential therapeutic targets.