CANT1抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using COL1A1 mouse mAb (green) and negative control (red).    

  
  

The CANT1 antibody is a tool used to detect and study the CANT1 protein (Calcium-Activated Nucleotidase 1), which is encoded by the *CANT1* gene. CANT1 is a member of the apyrase family and functions as a calcium-dependent nucleotidase, primarily hydrolyzing UDP, GDP, and other nucleotide diphosphates. It plays a critical role in regulating extracellular nucleotide levels, influencing processes like glycosylation, cartilage development, and extracellular matrix remodeling. Dysregulation of CANT1 has been linked to genetic disorders such as Desbuquois dysplasia type 1. a rare skeletal disorder characterized by short stature and joint abnormalities, caused by loss-of-function mutations. Conversely, CANT1 overexpression has been observed in certain cancers, suggesting a potential role in tumor progression.

CANT1 antibodies are widely used in research to investigate protein expression patterns, localization (e.g., endoplasmic reticulum or Golgi apparatus), and functional mechanisms in both physiological and pathological contexts. They are essential in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial CANT1 antibodies are typically developed using recombinant protein fragments or synthetic peptides as immunogens, with validation in specific experimental models. Researchers rely on these antibodies to explore therapeutic targets for skeletal diseases or cancer, though cross-reactivity and specificity challenges require careful validation. Overall, CANT1 antibodies are vital for unraveling the protein's role in development, disease, and cellular homeostasis.