S100A11抗体,Rabbit Polyclonal S100A11 Antibody
  • S100A11抗体,Rabbit Polyclonal S100A11 Antibody
  • S100A11抗体,Rabbit Polyclonal S100A11 Antibody
  • S100A11抗体,Rabbit Polyclonal S100A11 Antibody

S100A11抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
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产品详情

中文名称:S100A11抗体英文名称:Rabbit Polyclonal S100A11 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4329 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: S100A11
2025-05-19 S100A11抗体 Rabbit Polyclonal S100A11 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4329 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/1000-1/5000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesMLN70; S100C; HEL-S-43
WB Predicted band size12 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human S100A11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hepg2 cells, A549 cells, Primary antibody: P08730(S100A11 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P08730(S100A11 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于S100A11抗体的3篇参考文献及其简要摘要:

1. **文献名称**: *S100A11 promotes human pancreatic cancer cell invasion and is associated with poor prognosis in pancreatic cancer*

**作者**: Chen H et al. (2015)

**摘要**: 研究通过免疫组化(使用S100A11抗体)发现S100A11在胰腺癌组织中高表达,与患者预后不良相关,并通过调控MMP2/9促进癌细胞侵袭。

2. **文献名称**: *S100A11 is a potential therapeutic target for cutaneous squamous cell carcinoma*

**作者**: Sakaguchi M et al. (2016)

**摘要**: 利用S100A11抗体验证其在皮肤鳞癌中的高表达,发现其通过激活MAPK通路促进肿瘤增殖,提示其作为治疗靶点的潜力。

3. **文献名称**: *S100A11 interacts with annexin A2 to promote cisplatin resistance in cervical cancer cells*

**作者**: Wang L et al. (2018)

**摘要**: 研究通过免疫共沉淀(S100A11抗体)揭示S100A11与膜联蛋白A2结合,增强宫颈癌细胞对顺铂的耐药性,靶向此通路可逆转耐药。

4. **文献名称**: *Extracellular S100A11 regulates macrophage polarization and promotes tumor immunosuppression*

**作者**: Zhang Y et al. (2020)

**摘要**: 使用S100A11抗体检测肿瘤微环境中分泌型S100A11.发现其通过诱导M2型巨噬细胞极化抑制抗肿瘤免疫反应,促进肿瘤进展。

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以上文献均通过S100A11抗体探究其在不同癌症中的表达、功能及机制,涵盖基础研究和临床相关性。

       

背景信息

S100A11. a member of the S100 calcium-binding protein family, plays diverse roles in cellular processes such as proliferation, differentiation, apoptosis, and inflammation regulation. It functions as a calcium sensor, modulating intracellular signaling pathways through interactions with target proteins like annexins and cytoskeletal components. S100A11 is implicated in cancer progression, where its expression is often dysregulated, correlating with tumor invasiveness, metastasis, and poor prognosis in cancers such as gastric, ovarian, and colorectal carcinomas. It also participates in membrane repair, calcium homeostasis, and immune responses.

Antibodies against S100A11 are critical tools for studying its expression, localization, and functional mechanisms. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in both research and diagnostic applications. Commercially available S100A11 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes to ensure specificity. Validation includes testing on recombinant proteins or knockout cell lines to confirm minimal cross-reactivity with other S100 family members.

Research using S100A11 antibodies has revealed its dual role in cancer—acting as either an oncogenic promoter or tumor suppressor, depending on context. Additionally, studies explore its involvement in inflammatory diseases and cellular stress responses. Ongoing efforts focus on developing therapeutic strategies targeting S100A11 or its pathways, particularly in oncology. Reliable antibodies remain essential for unraveling its complex biology and translational potential.

       
关键字: S100A11抗体;S100A11;S100A11 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
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员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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