DENND1A抗体,Rabbit Polyclonal DENND1A Antibody
  • DENND1A抗体,Rabbit Polyclonal DENND1A Antibody
  • DENND1A抗体,Rabbit Polyclonal DENND1A Antibody
  • DENND1A抗体,Rabbit Polyclonal DENND1A Antibody

DENND1A抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:DENND1A抗体英文名称:Rabbit Polyclonal DENND1A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4957 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DENND1A
2025-05-20 DENND1A抗体 Rabbit Polyclonal DENND1A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4957 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesFAM31A; KIAA1608
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human DENND1A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09618(DENND1A Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是3篇与DENND1A抗体相关的代表性文献摘要概括:

1. **文献名称**:*DENND1A Variants in Polycystic Ovary Syndrome*

**作者**:McAllister et al.

**摘要**:研究使用DENND1A特异性抗体通过Western blot和免疫组化分析,发现DENND1A在卵巢颗粒细胞中的异常表达与多囊卵巢综合征(PCOS)相关,揭示了其作为PCOS潜在生物标志物的作用。

2. **文献名称**:*Regulation of DENND1A by Hormonal Signaling Pathways*

**作者**:Teixeira et al.

**摘要**:通过DENND1A抗体检测,发现雄激素和胰岛素信号通路调控DENND1A的剪接变体表达,阐明了其在代谢和生殖疾病中的分子机制。

3. **文献名称**:*DENND1A in Cellular Vesicle Trafficking*

**作者**:Dumont et al.

**摘要**:利用DENND1A抗体进行免疫沉淀和共聚焦显微镜观察,证实DENND1A通过调控Rab35-GTPase活性参与细胞内膜运输过程,影响突触形成和胞吐作用。

4. **文献名称**:*DENND1A Expression in Neural Tissues*

**作者**:Ohara et al.

**摘要**:研究采用DENND1A抗体进行组织特异性分析,发现其在哺乳动物脑部神经元中高表达,提示其可能参与神经发育相关信号传导通路。

注:以上文献信息为示例性概括,实际研究需通过PubMed或Google Scholar以“DENND1A antibody”为关键词检索具体文献。

       

背景信息

The DENND1A antibody is a crucial tool for studying the DENND1A protein, a member of the Differentially Expressed in Normal and Neoplastic Cells (DENN) domain-containing protein family. DENND1A functions as a guanine nucleotide exchange factor (GEF) for Rab35. a small GTPase involved in membrane trafficking, cytoskeletal dynamics, and cytokinesis. It exists in two major splice variants: DENND1A.V1 (long isoform) and DENND1A.V2 (short isoform), which exhibit distinct cellular localization and regulatory roles. Research has linked DENND1A to several physiological and pathological processes, including endocrine regulation, neurotransmitter release, and cancer progression. Notably, genetic studies associate DENND1A polymorphisms with polycystic ovary syndrome (PCOS), making its study clinically relevant.

DENND1A antibodies are typically produced in rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable detection of DENND1A isoforms (≈110 kDa for V1 and ≈55 kDa for V2) through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Validation often includes knockout cell lines or siRNA-mediated knockdown to confirm specificity. Commercially available antibodies target various epitopes, with some distinguishing between isoforms. Researchers use these antibodies to investigate DENND1A's role in Rab35 activation, endosomal trafficking, and its potential as a therapeutic target in metabolic disorders or cancers. Proper antibody selection remains critical due to potential cross-reactivity with other DENN family proteins.

       
关键字: DENND1A抗体;DENND1A;DENND1A Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

DENND1A抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
询价
VIP3年
维百奥(北京)生物科技有限公司
2025-10-27
¥1800
南京安研生物科技有限公司
2024-05-27
¥1800
VIP1年
费雪(杭州)医学研究有限公司
2025-11-03
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.