VTCN1抗体,Rabbit Polyclonal VTCN1 Antibody
  • VTCN1抗体,Rabbit Polyclonal VTCN1 Antibody
  • VTCN1抗体,Rabbit Polyclonal VTCN1 Antibody
  • VTCN1抗体,Rabbit Polyclonal VTCN1 Antibody

VTCN1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:VTCN1抗体英文名称:Rabbit Polyclonal VTCN1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5700 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: VTCN1
2025-05-21 VTCN1抗体 Rabbit Polyclonal VTCN1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5700 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesB7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; RP11-229A19.4
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human VTCN1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10713(VTCN1 Antibody) at dilution 1/20. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10713(VTCN1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于VTCN1(B7-H4)抗体的研究文献示例(内容基于公开研究整理,非真实文献):

1. **文献名称**:*Targeting VTCN1 (B7-H4) enhances antitumor immune responses in ovarian cancer*

**作者**:Lei Wang et al.

**摘要**:研究证明VTCN1在卵巢癌细胞中高表达,通过特异性抗体阻断VTCN1可逆转T细胞功能抑制,抑制肿瘤生长并延长小鼠模型生存期。

2. **文献名称**:*B7-H4 antibody therapy synergizes with PD-1 blockade in colorectal cancer models*

**作者**:Zang X. et al.

**摘要**:开发靶向B7-H4的单克隆抗体,发现其与抗PD-1联用可显著增强抗肿瘤活性,减少调节性T细胞浸润,改善结直肠癌临床前模型的治疗效果。

3. **文献名称**:*B7-H4 expression in breast cancer and its therapeutic implications*

**作者**:Sahin S. et al.

**摘要**:分析乳腺癌中B7-H4的免疫逃逸机制,表明抗B7-H4抗体通过激活CD8+ T细胞和抑制Treg功能,显著降低肿瘤负荷并增强化疗敏感性。

4. **文献名称**:*VTCN1 as a biomarker and therapeutic target in pancreatic adenocarcinoma*

**作者**:Villarroel M. et al.

**摘要**:揭示胰腺癌中VTCN1的过表达与免疫抑制微环境相关,使用人源化抗体可阻断VTCN1信号,恢复T细胞活性并抑制肿瘤转移。

(注:以上文献为示例,实际研究需通过学术数据库检索确认。)

       

背景信息

VTCN1 (B7-H4) is a transmembrane protein belonging to the B7 family of immune checkpoint regulators, primarily involved in modulating T-cell-mediated immune responses. Expressed on antigen-presenting cells and certain non-hematopoietic tissues, VTCN1 interacts with an unknown receptor on T cells to suppress their activation, proliferation, and cytokine production. This inhibitory mechanism helps maintain immune tolerance but is frequently exploited by tumors to evade immune surveillance. Overexpression of VTCN1 has been documented in various cancers, including breast, ovarian, and pancreatic malignancies, correlating with poor prognosis and resistance to therapies.

Antibodies targeting VTCN1 aim to block its immunosuppressive signaling, thereby restoring antitumor immunity. Preclinical studies demonstrate that anti-VTCN1 antibodies enhance T-cell activity and synergize with PD-1/PD-L1 inhibitors. However, challenges remain, such as identifying optimal therapeutic contexts and managing potential autoimmune side effects due to VTCN1’s expression in healthy tissues. Several anti-VTCN1 agents, including monoclonal antibodies and antibody-drug conjugates, are under investigation in early-phase clinical trials. Research continues to explore its dual role as a diagnostic biomarker and therapeutic target, highlighting its potential in precision immuno-oncology strategies.

       
关键字: VTCN1抗体;VTCN1;VTCN1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

VTCN1抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥1950
VIP4年
上海沪震实业有限公司
2026-02-02
¥1600.00
VIP10年
北京索莱宝科技有限公司
2026-01-30
¥1800
VIP2年
费雪(杭州)医学研究有限公司
2026-01-05
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 京ICP备07040585号  京公海网安备110108000080号  All rights reserved.