SIX6抗体;SIX6 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13588(SIX6 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SIX6 antibody is a tool used to detect the SIX6 protein, encoded by the *SIX6* gene, which belongs to the Six family of homeobox transcription factors. SIX6 plays a critical role in embryonic development, particularly in eye organogenesis, where it regulates the differentiation and proliferation of retinal progenitor cells. It is highly expressed in the developing optic vesicle, lens, and retina. Mutations or dysregulation of *SIX6* have been linked to congenital eye disorders, including microphthalmia, anophthalmia, and coloboma, as well as adult-onset conditions like primary open-angle glaucoma (POAG). Studies suggest that SIX6 variants may influence optic nerve degeneration by altering retinal ganglion cell survival.

The SIX6 antibody is widely used in research to study protein expression patterns, subcellular localization, and functional interactions in developmental and disease contexts. It aids in investigating SIX6's role in transcriptional regulation, particularly its binding to target DNA sequences and modulation of downstream genes. Commercial SIX6 antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Researchers also utilize these antibodies to explore potential therapeutic strategies targeting SIX6-related pathways in ocular diseases. Proper validation, including knockout controls, is essential to ensure specificity due to homology within the Six protein family.