Rab11b抗体;Rab11b Antibody—艾普蒂

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     IHC-P analysis of mouse brain tissue by Rab11b antibody (P15658) IHC-P was performed using sections of the formalin-fixed paraffin-embedded mouse brain tissue;Result: Neurons are positively stained at the cytoplasm.    

  
  

Rab11b antibody is a crucial tool for studying the function and localization of Rab11b, a member of the Rab GTPase family involved in regulating intracellular vesicular trafficking. Rab11b primarily localizes to recycling endosomes and plays a key role in mediating the transport of cargo proteins and membranes between endosomal compartments, the trans-Golgi network, and the plasma membrane. It is particularly important in processes such as cytokinesis, neurite outgrowth, and synaptic plasticity. Dysregulation of Rab11b has been implicated in neurodegenerative diseases, cancer, and immune disorders, making it a target for biomedical research.

Rab11b antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect expression levels, subcellular distribution, and interactions of Rab11b in various cell types or tissues. These antibodies are typically raised against specific epitopes of human or mouse Rab11b, with validation including knockout/knockdown controls to confirm specificity. Due to high sequence homology between Rab11 isoforms (e.g., Rab11a and Rab11b), many commercial antibodies are rigorously tested to ensure minimal cross-reactivity. Researchers often employ Rab11b antibodies in studies exploring membrane trafficking dynamics, receptor recycling (e.g., GPCRs), and pathological mechanisms linked to vesicle transport defects. Recent applications extend to investigating exosome biogenesis and autophagy pathways.