HOXA13抗体;HOXA13 Antibody—艾普蒂

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     Western blot analysis of HOXA13 expression in 293T cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The HOXA13 antibody is a crucial tool in studying the HOXA13 protein, a member of the homeobox (HOX) gene family, which plays essential roles in embryonic development, particularly in limb, genital, and urogenital tract patterning. HOX genes encode transcription factors that regulate morphogenesis by controlling spatial identity along the body axis. HOXA13. located at the 5' end of the HOXA cluster, is critical for distal limb development and differentiation of the reproductive system. Mutations in HOXA13 are linked to genetic disorders like hand-foot-genital syndrome (HFGS), characterized by limb malformations and urogenital defects. In cancer research, HOXA13 dysregulation is associated with tumor progression in prostate, colorectal, and endometrial cancers, where it may influence cell proliferation, invasion, or metastasis.

The HOXA13 antibody is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HOXA13 expression levels and subcellular localization in tissues or cell lines. Validated antibodies help elucidate its role in developmental pathways, disease mechanisms, and potential therapeutic targets. Researchers often verify specificity using knockout controls or siRNA knockdowns. Commercial HOXA13 antibodies may vary in clonality (monoclonal/polyclonal), epitope regions, and host species (e.g., rabbit, mouse). Proper validation ensures reliability in both research and diagnostic contexts, aiding in the exploration of HOXA13’s dual roles in development and pathology.