Product Name：Amylin,amide,human acetate
CAS No.：122384-88-7
Synonyms：糖尿病相关肽(胰岛淀粉样肽)
Catalog No.：106P01
Brand：Typeptide Biotech（肽研生物）
Description：Amylin,amide,human acetate是一种37个氨基酸的多肽，是一种与胰岛素共分泌的胰腺激素，在代谢和葡萄糖稳态中发挥独特的作用。能抑制胰高血糖素分泌，延迟胃排空，并作为饱腹剂。MCF-7 细胞内源性表达人胰淀素受体 CTR1 和 CTR2。 用胰淀素、酰胺、人刺激受体导致产生 cAMP。 Amylin, amide, human (0.001 nM-1000 μM) 导致 EC50 为 35.2±7.5 nM。通过皮下途径注射到不同的瑞士雄性小鼠组中。 观察到游离胰淀素的典型 PK 曲线，半衰期为 23 分钟。
Amylin, amide, human acetate is a 37-amino acid polypeptide, a pancreatic hormone co-secreted with insulin, which plays a unique role in metabolism and glucose homeostasis. It inhibits glucagon secretion, delays gastric emptying, and functions as a satiety agent. MCF-7 cells endogenously express human amylin receptors CTR1 and CTR2. Stimulation of these receptors with amylin, amide, human leads to the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) resulted in an EC50 of 35.2±7.5 nM. It was administered subcutaneously to different groups of Swiss male mice. A typical PK curve of free amylin was observed, with a half-life of 23 minutes.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2(Disulfide bridge：Cys2-Cys7) |
Sequence(3-letter code) | H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bond：Cys2-Cys7) |
Peptide Structure | 
|
Molecular Formula | C165H261N51O55S2 |
Molecular Weight | 3903.32 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： Amylin,amide,human a;糖尿病相关肽(胰岛淀粉样肽);122384-88-7;多肽;多肽合成;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。