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B7-2/CD86 蛋白
品牌:MedChemExpress (MCE)
货号:HY-P7635
纯度:Greater than 95% as determined by reducing SDS-PAGE.
产品活性:B7-2/CD86 蛋白, Mouse (HEK293, Fc)是 CLTA4 的配体,在小鼠 B细胞上表达,可作为 T 细胞活化的共刺激分子。
研究背景:抑制CD28与B7-2分子的相互作用可能代表治疗肺粘膜过敏性炎症的新治疗靶点。过敏原刺激后,肺 B 细胞上的 B7-2(而非 B7-1)上调[1][2]。
种属:Mouse
蛋白编号:P42082 (V26-E245)
基因 ID:12524
同用名:rMuB7-2, C-Fc; T-lymphocyte activation antigen CD86; Early T-cell costimulatory molecule 1; ETC-1; CD86
详情参考:http://www.medchemexpress.cn/cytokines/b7-2-cd86-protein-mouse-hek293-fc.html
参考文献:
[1]. K S Hathcock, et al. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med. 1994 Aug 1;180(2):631-40.
[2]. S Tsuyuki, et al. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J Exp Med. 1997 May 5;185(9):1671-9.