货号:GS40747
Trevogrumab (REGN-1033) is a humanized IgG4 kappa monoclonal antibody targeting growth/differentiation factor 8 (GDF8, also known as myostatin), a negative regulator of skeletal muscle growth. It binds to and neutralizes myostatin, blocking its interaction with the activin type IIB receptor (ActRIIB) to promote muscle hypertrophy and strength. It is being developed for the treatment of sarcopenia, muscle-wasting disorders, and certain neuromuscular conditions.
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