Synonym: vitamin H, coenzyme R, Vitamin B7, D(+)-Biotin, Biodermatin, Bioepiderm, Bios II,,
Catalog #: 8603001
Purity: 98%
CAS No.: 58-85-5
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31
Compound ID: 171548
Description: Avidin-biotin technology has become a commercially viable tool for research, medical and industrial applications. From the beginning, mediation via the avidin-biotin complex was proposed for affinity-based separations. The biotin-(strept)avidin system has been used for many years in a variety of different applications. Avidin and streptavidin are widely used in (strept)avidin-biotin technology, which is based on their tight biotin-binding capability. These techniques are exceptionally diverse, ranging from simple purification and labeling methods to sophisticated drug pre-targeting and nanostructure-building approaches. Avidin and streptavidin provide a promising scaffold for protein engineering, and due to their ultratight binding to D-biotin they are widely used in various biotechnological and biomedical applications. The ‘adaptor’ is a tetrameric protein, namely, streptavidin, that is able to achieve high-affinity binding of d-biotin (K(d) = 10(-15) M) and confer avidity to the address peptide. This binding ability facilitates the generation of anti-melanoma diagnostic and therapeutic agents using the appropriate biotin derivatives.