SD2443-25mg
Vilanterol (β2激动剂)
25mg
3181.00元
化学信息：
化学名
4-[(1R)-2-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol
别名
GW 642444X, GW 642444, GW642444X, GW642444, GW-642444X, GW-642444
溶剂/溶解度
Water<1mg/ml; DMSO5mg/ml; Ethanol<1mg/ml
溶液配制
5mg加入1.03ml DMSO，或者每4.86mg加入1ml DMSO，配制成10mM溶液。SD2443-10mM用DMSO配制。
生物信息：
产品描述
Vilanterol (GW642444; GW 642444X) is a novel, inhaled, long-acting β(2) agonist with inherent 24-h activity under development as a once-daily combination therapy with an inhaled corticosteroid for COPD and asthma.
体外研究
Vilanterol displayed a subnanomolar affinity for the β(2)-AR that was comparable with that of salmeterol but higher than olodaterol, formoterol, and indacaterol. In cAMP functional activity studies, vilanterol demonstrated similar selectivity as salmeterol for β(2)- over β(1)-AR and β(3)-AR, but a significantly improved selectivity profile than formoterol and indacaterol. Vilanterolalso showed a level of intrinsic efficacy that was comparable to indacaterol but significantly greater than that of salmeterol.
体内研究
in vivo: The combination of FF/VI at a strength of 100/25μg significantly (p<0.001) improved wm FEV1 (173ml) and trough FEV1 (115ml) vs. placebo. Similar effects were observed with FF/VI 50/25μg. VI 25μg over 24weeks improved lung function vs. placebo significantly for wm FEV1 (103ml, p<0.001) and trough FEV1 (67ml, p=0.017).
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
参考文献：
1. Slack RJ, et al. J Pharmacol Exp Ther. 2013 Jan, 344(1), 218-30.
2. Slack RJ, et al. J Pharmacol Exp Ther. 2013 Jan, 344(1), 218-30.
3. Kerwin EM, et al. Respir Med. 2013 Apr, 107(4), 560-9.
4. Hanania NA, et al. Chest. 2012 Jul, 142(1), 119-27.
包装清单：
SD2443-10mM
Vilanterol (β2激动剂)
10mM×0.2ml
SD2443-5mg
Vilanterol (β2激动剂)
5mg
SD2443-25mg
Vilanterol (β2激动剂)
25mg
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。