胆固醇

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抑制剂描述：

产品名称：Cholesterol

产品别名：胆固醇

英文别名：Cholesterol

靶点：MRP1；RORα

CAS：57-88-5

纯度：＞99%

外观：白色或淡黄色结晶性粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Cholesterol is the major sterol in mammals, and its importance in fundamental cellular processes is becoming more appreciated.

溶解性：DMSO : 0.79 mg/mL (2.04 mM; Need warming)

体外研究：

Cholesterol serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. It modulates membrane fluidity over the range of physiological temperatures. The hydroxyl group on cholesterol interacts with the polar head groups of the membrane phospholipids and sphingolipids, while the bulky steroid and the hydrocarbon chain are embedded in the membrane, alongside the nonpolar fatty-acid chain of the other lipids. Through the interaction with the phospholipid fatty-acid chains, cholesterol increases membrane packing, which reduces membrane fluidity. The structure of the tetracyclic ring of cholesterol contributes to the decreased fluidity of the cell membrane as the molecule is in a trans conformation making all but the side chain of cholesterol rigid and planar. In this structural role, cholesterol reduces the permeability of the plasma membrane to neutral solutes, protons, and sodium ions.

体内研究：Cholesterol is recycled. The liver excretes it in a non-esterified form (via bile) into the digestive tract. Typically about 50% of the excreted cholesterol is reabsorbed by the small bowel back into the bloodstream.

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