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抑制剂描述:
产品名称:Flutamide
产品别名:氟他胺
英文别名:SCH 13521
靶点:Androgen Receptor
CAS:13311-84-7
纯度:>98%
外观:淡黄色结晶性粉末
保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
描述:
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor.
溶解性:DMSO : 51 mg/mL (184.6 mM)
Ethanol : 51 mg/mL (184.6 mM)
体外研究:
Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM. Flutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect. Flutamide provides treatment for prostate cancer when used along with leuprolide.
体内研究:Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity.
产品信息订购:
abs816702
Flutamide
50mg
270
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