PMA/TPA (PKC激活剂)
中文名称：PMA/TPA (PKC激活剂)
英文名称：Phorbol 12-myristate 13-acetate
产品规格：1mg
Phorbol 12-myristate 13-acetate (PMA) is a phorbol ester that is commonly used to activate certain types of protein kinase C (PKC),including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. Phorbol esters, including PMA, are structurally analogous todiacylglycerol and activate PKC isoforms by associating with their C1 domains.Through PKC, PMA also activates certain MAPkinase pathways.Prolonged treatment of cells with PMA at high concentrations results in the downregulation of total PKC activityand is tumorigenic, whereas lower concentrations may be protective. In addition, PMA promotes hematopoietic differentiation. Theaqueous solubility of PMA is about 10-fold better than that of phorbol-12,13-dibutyrate, indicating that PMA is preferable incell-based studies.
CAS：16561-29-8分子式：C36H56O8分子量：616.8纯度：≥98%
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关键字： PMA/TPA (PKC激活剂);Phorbol 12-myristate 13-acetate
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