| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
2500ug/kg (2.5mg/kg) |
|
Biochemical Pharmacology. Vol. 30, Pg. 771, 1981. |
| mouse |
LD50 |
intravenous |
20mg/kg (20mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
| mouse |
LD50 |
oral |
196mg/kg (196mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
| rabbit |
LDLo |
oral |
250mg/kg (250mg/kg) |
|
Journal of Medical Research. Vol. 42, Pg. 461, 1919. |
| rat |
LD50 |
intraperitoneal |
14700ug/kg (14.7mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
| rat |
LD50 |
intravenous |
17100ug/kg (17.1mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
| rat |
LD50 |
oral |
501mg/kg (501mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
| rat |
LD50 |
subcutaneous |
350mg/kg (350mg/kg) |
|
Progress in Medical Chemistry. Vol. 15, Pg. 211, 1977. |
| rat |
LD50 |
subcutaneous |
350mg/kg (350mg/kg) |
MUSCULOSKELETAL: JOINTS |
Progress in Medical Chemistry. Vol. 15, Pg. 211, 1977. |