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Cell Death & Disease

Cell Death & Disease

IF:8.1 CiteScore:15.1 Articles:935
Brought to readers by the editorial team of Cell Death & Differentiation, Cell Death & Disease is an online peer-reviewed journal specializing in translational cell death research. It covers a wide range of topics in experimental and internal medicine, including cancer, immunity, neuroscience, and now cancer metabolism. Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following: Experimental medicine Cancer Immunity Internal medicine Neuroscience Cancer metabolism

Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function

Published: 21 October 2025 DOI: 10.1038/s41419-025-08057-2
Xingzhi Peng, Peijun Zhou, Kun Zhang, Likang Chen, Min Tang, Qin Zhou, Jinwu Peng, Lifang Yang

Activating PIK3CA mutation promotes overgrowth of adipose tissue via inhibiting lipophagy in macrodactyly

Published: 6 October 2025 DOI: 10.1038/s41419-025-08024-x
Yating Yin, Xiao Zhang, Shihui Lin, Zhibo Wang, Baoxing Tian, Xinyi Dai, Aiping Yu, Huixiao Li, Hailei Mao, Bin Wang

YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer

Published: 1 September 2025 DOI: 10.1038/s41419-025-07886-5
Tianyi Zhao, Xiaojun Chen, Jiangchun Wu, Siyu Chen, Yu Gan, Chaohua Liu, Xinyu Ha, Yangjun Wu, Xiang Zhou, Yong Wu, Xiaohua Wu

Targeting Irgm1 to combat osteoporosis: suppressing ROS and restoring bone remodeling

Published: 27 August 2025 DOI: 10.1038/s41419-025-07965-7
Zichen Cui, Guanghui Gu, Fei Chen, Jianyi Li, Xiaofan Du, Shuqing Chen, Han Zhang, Chenxu Li, Jiale Shao, Jiayi Xi, Yukun Du, Qinghua Zhao, Yongming Xi

GFAT1 promotes the progression of hepatocellular carcinoma via enhancing the O-GlcNAcylation of VEZF1

Published: 26 August 2025 DOI: 10.1038/s41419-025-07975-5
Jia-Yao Yang, Rong Zhang, Zhi-Rong Zhang, Shan Li, De-Ao Gong, Chen-Hao Li, Chang Chen, Lu-Yi Huang, Ai-Long Huang, Ni Tang, Kai Wang

TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification

Published: 16 August 2025 DOI: 10.1038/s41419-025-07922-4
Xiaoqing Li, Ying Wu, Jiahao Guo, Peng Huang, Qiuhui Li, Zhongyu Gao, Yanming Hu, Aidi Gao, Ming Sun, Han Min, Jundong Zhou

The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia

Published: 13 August 2025 DOI: 10.1038/s41419-025-07927-z
Xiuying Hu, Tianzhen Hu, Shuyun Cao, Li Jiang, Yan Zhou, Qin Fang, Jishi Wang

Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins

Published: 12 August 2025 DOI: 10.1038/s41419-025-07949-7
Huimin Jiang, Yongjian Wang, Churan Wang, Lu Yang, Shujuan Wang, Feng Wang, Situ Xue, Zhuan Zhang, Haigen Fu, Ting Dong, Jian Yuan, Zhuorong Li, Ke Li

LncRNA EP300-AS1 interacts with PTBP1 to destabilize PRMT5 mRNA and suppresses NSCLC growth and metastasis

Published: 11 August 2025 DOI: 10.1038/s41419-025-07931-3
Jingyi Chen, Chongyu Fan, Songze Song, Deyu Zhang

Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation

Published: 7 August 2025 DOI: 10.1038/s41419-025-07906-4
Guang-Xi Yang, De-Liang Peng, Lin Chen, Yu Qian, Le He, Xiao-Yan Chen, Wen-Bin Hong, Cai-Ming Wu, Hang-Zi Chen

(+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway

Published: 23 July 2025 DOI: 10.1038/s41419-025-07880-x
Mengxue Yang, Ting Wang, Jingrong Shao, Xinna Ran, Rui Xiao, Rui Zhao, Chunyan Wu, Ming Ji, Weiping Tian, Huabing Sun, Jiao Liu, Shengkai Zuo

Molecular features of TNBC govern heterogeneity in the response to radiation and autophagy inhibition

Published: 21 July 2025 DOI: 10.1038/s41419-025-07873-w
Patrick Fischer, Maximilian Schmid, Anna Ohradanova-Repic, Rebecca Schneeweiss, Jana Hadatsch, Odysseus Grünert, Johannes Benedum, Anna Röhrer, Felix Staudinger, Philipp Schatzlmaier, Niccolo Bragato, Sandra Barna, Magdalena Engl, Ava Kleinwächter, Dietmar Georg, Joachim Widder, Sylvia Kerschbaum-Gruber, Dea Slade

CENPT prevents renal cell carcinoma against ferroptosis by enhancing the synthesis of glutathione

Published: 12 July 2025 DOI: 10.1038/s41419-025-07848-x
Han Yang, Zongliang Zhang, Ninghan Feng, Kai Zhao, Yulian Zhang, Xinbao Yin, Guanqun Zhu, Zhenlin Wang, Xuechuan Yan, Xueyu Li, Zhaofeng Li, Qinglei Wang, Yixin Qi, Peng Zhao, Tianzhen He, Ke Wang

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis

Published: 17 June 2025 DOI: 10.1038/s41419-025-07770-2
Gaoyan Tang, Xuelei Cao, Jiaqi Chen, Fu Hui, Na Xu, Yiqing Jiang, Hongmin Lu, Haifeng Xiao, Xiuming Liang, Mingzhe Ma, Yu Qian, Dongli Liu, Zhenlu Wang, Shuzhen Liu, Guohua Yu, Lei Sun

MBD2 promotes B cell differentiation and BCR signaling in systemic lupus erythematosus by regulating the LEF-1-PTEN-PI3K axis

Published: 4 June 2025 DOI: 10.1038/s41419-025-07750-6
Yukai Jing, Yunfei Zhang, Xiaocui Wang, Yufen Wang, Ying Hu, Bin Wen, Xin Dai, Xuemei Duan, Haonan Li, Shumin Dong, Ze Yan, Yufeng Fan, Cong-Yi Wang, Xiansheng Liu, Ruiping Zhang

Therapeutic efficacy of TMTP1-modified EVs in overcoming bone metastasis and immune resistance in PIK3CA mutant NSCLC

Published: 6 May 2025 DOI: 10.1038/s41419-025-07685-y
Liwen Liu, Tanghesi Wuyun, Xin Sun, Yu Zhang, Geqi Cha, Ling Zhao

Prostate cancer exploits BRD9-driven metabolic reprogramming to shape the aggressive phenotype

Published: 22 April 2025 DOI: 10.1038/s41419-025-07561-9
Ye Lv, Xinkai Mo, Ruojia Zhang, Yu Peng, Tingting Feng, Yuang Zhang, Guanhua Song, Luna Ge, Yu Liu, Guiwen Yang, Lin Wang

Endoplasmic reticulum stress related super-enhancers suppress cuproptosis via glycolysis reprogramming in lung adenocarcinoma

Published: 19 April 2025 DOI: 10.1038/s41419-025-07613-0
Yan Gu, Hongchang Wang, Wentao Xue, Linjia Zhu, Chenghao Fu, Wenhao Zhang, Guang Mu, Yang Xia, Ke Wei, Jun Wang

17-beta estradiol prevents cardiac myocyte hypertrophy by regulating mitochondrial E3 ubiquitin ligase 1

Published: 19 February 2025 DOI: 10.1038/s41419-025-07389-3
Ximena Calle, Valeria Garrido-Moreno, Brenda Becerra, Mayarling F Troncoso, Juan Francisco Silva-Agüero, Emanuel Guajardo-Correa, Leslye Venegas-Zamora, Erik Lopez-Gallardo, Felipe Muñoz-Córdova, Fernanda Fredericksen, Sebastian Aedo-Cares, Allan Peñaloza-Otárola, Angelica Ortega, Angel Raya, Vinicius Maracaja-Coutinho, Mario Chiong, Valentina Parra, Sergio Lavandero

Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma

Published: 6 February 2025 DOI: 10.1038/s41419-025-07412-7
Yue Dai, Hongchen Li, Shiyin Fan, Kai Wang, Ziyi Cui, Xinyu Zhao, Xue Sun, Mingen Lin, Jiaxi Li, Yi Gao, Ziyin Tian, Hui Yang, Bingbing Zha, Lei Lv, Yanping Xu
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