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Cell Death Discovery

Cell Death Discovery

IF:6.1 CiteScore:8.3 Articles:468
Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.

Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma

Published: 6 October 2025 DOI: 10.1038/s41420-025-02756-7
Jingwei Yao, Mengqi Li, Yuelong Jiang, Nanye Yao, Yating Liu, Liemei Lv, Yuchen Li, Jiewen Huang, Jie Zha, Bing Xu

Inhibition of ferroptosis in inflammatory macrophages alleviates intestinal injury in neonatal necrotizing enterocolitis

Published: 5 August 2025 DOI: 10.1038/s41420-025-02665-9
Leiting Shen, Jiayu Chen, Jinfa Tou

MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1

Published: 26 May 2025 DOI: 10.1038/s41420-025-02426-8
Yajing Yang, Yan Ma, Shiyin Fan, Jie Zhu, Bin Ye, Ruonan Zhang, Jiaxi Li, Hongchen Li, Zhencang Zheng, Yufeng Li, Lei Lv

GPX1 confers resistance to metabolic stress in BCR/ABL-T315I mutant chronic myeloid leukemia cells

Published: 9 May 2025 DOI: 10.1038/s41420-025-02502-z
Jun-Dan Wang, Jin-Xing Wang, Zhi-Li Lin, Na Xu, Ling Zhang, Jia-Jun Liu, Rui Gao, Zi-Jie Long

Sotorasib-impaired degradation of NEU1 contributes to cardiac injury by inhibiting AKT signaling

Published: 12 April 2025 DOI: 10.1038/s41420-025-02431-x
Mengting Cheng, Wentong Wu, Qing Li, Xinyu Tao, Feng Jiang, Jinjin Li, Nonger Shen, Fei Wang, Peihua Luo, Qiaojun He, Ping Huang, Zhifei Xu, Yiwen Zhang

Systemic tumor regression with synergy therapy: radiotherapy and CAR-T

Published: 22 November 2024 DOI: 10.1038/s41420-024-02245-3
Ma, Xingyu, Zhang, Wei, Zeng, Miao, Asavasupreechar, Teeranut, Kang, Synat, Li, Yisheng, Yu, Li

SVIP reduces IGFBP-2 expression and inhibits glioblastoma progression via stabilizing PTEN

Published: 13 August 2024 DOI: 10.1038/s41420-024-02130-z
Zixuan Wang, Xiaolong Qiao, Yinan Chen, Nan Peng, Chaoshi Niu, Yang Wang, Cong Li, Zengchun Hu, Caihua Zhang, Chuandong Cheng

Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content

Published: 12 August 2024 DOI: 10.1038/s41420-024-02127-8
Si-Yu Cen, Fang Lin, Xuan Li, Yanglin Hu, Jin-Pin Liu, Zian Xue, Yun Gao, Yi-Ping Sun, Sanyong Zhu, Yongjun Dang, Yahui Zhao, Hai-Xin Yuan

LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism

Published: 22 June 2024 DOI: 10.1038/s41420-024-02072-6
Zhan Liu, Kexin Fan, Aikedaimu Abudukeremu, Min Gao, Xinyue Tan, Xiaojuan Mao, Xinyu Li, Wenting Ma, Xusheng Ma, Caolong Li, Yinglai Yang, Kangsheng Tu, Jing Chen, Yilei Zhang, Yaqun Guan

Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy

Published: 24 May 2024 DOI: 10.1038/s41420-024-02019-x
Huanying Shi, Lu Chen, Tianxiao Wang, Wenxin Zhang, Jiafeng Liu, Yuxin Huang, Jiyifan Li, Huijie Qi, Zimei Wu, Yi Wang, Haifei Chen, Yongjun Zhu, Qunyi Li

Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells

Published: 5 April 2024 DOI: 10.1038/s41420-024-01933-4
Zhiheng Zhang, Haruna Aoki, Keitaro Umezawa, Joshua Kranrod, Natsumi Miyazaki, Taichi Oshima, Takuya Hirao, Yuri Miura, John Seubert, Kousei Ito, Shigeki Aoki

Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1

Published: 23 February 2024 DOI: 10.1038/s41420-024-01861-3
Linyi Ma, Ying He, Huancheng Xie, Jing Wang, Jiaqian Chen, Shijie Song, Le Zhang, Linmei Li, He Lai, Yongping Liu, Huifang Chen, Xueyan Zhang, Xueting Liu, Zehong Zou, Qingling Zhang, Jie Yan, Ailin Tao

Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer

Published: 15 December 2023 DOI: 10.1038/s41420-023-01746-x
Ge Zhang, Wunan Mi, Chuyue Wang, Jiehan Li, Yizheng Zhang, Nannan Liu, Meimei Jiang, Guiyun Jia, Feng Wang, Ge Yang, Lingling Zhang, Jiangang Wang, Yang Fu, Yingjie Zhang

Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells

Published: 13 October 2023 DOI: 10.1038/s41420-023-01672-y
Chenyu Qiu, Xin Shen, Hui Lu, Yinghua Chen, Chenxin Xu, Peisen Zheng, Yiqun Xia, Junqi Wang, Yafei Zhang, Shaotang Li, Peng Zou, Ri Cui, Jundixia Chen

AGER1 deficiency-triggered ferroptosis drives fibrosis progression in nonalcoholic steatohepatitis with type 2 diabetes mellitus

Published: 6 June 2023 DOI: 10.1038/s41420-023-01477-z
Yihui Gong, Zijun Liu, Yuanyuan Zhang, Jun Zhang, Yin Zheng, Zhongming Wu

Phosphorylation of UHRF2 affects malignant phenotypes of HCC and HBV replication by blocking DHX9 ubiquitylation

Published: 24 January 2023 DOI: 10.1038/s41420-023-01323-2
Kejia Wu, Yiqi Zhang, Yuxin Liu, Qingxiu Li, Yong Chen, Juan Chen, Changzhu Duan

Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis

Published: 17 May 2022 DOI: 10.1038/s41420-022-01051-z
Kun Fan, Xiaojian Ni, Sheng Shen, Zijun Gong, Ji-wen Wang, Yanlei Xin, Bohao Zheng, Wentao Sun, Han Liu, T. Suo, X. Ni, Houbao Liu

Targeting matrix metallopeptidase 2 by hydroxyurea selectively kills acute myeloid mixed-lineage leukemia

Published: 8 April 2022 DOI: 10.1038/s41420-022-00989-4
Ruiheng Wang, Shufeng Xie, Shouhai Zhu, Yong Sun, Bowen Shi, Dan Li, Ting Kang, Yuanli Wang, Zhenshu Xu, Han Liu

Upregulation of CPNE7 in mesenchymal stromal cells promotes oral squamous cell carcinoma metastasis through the NF-κB pathway

Published: 14 October 2021 DOI: 10.1038/s41420-021-00684-w
Xiaoli Ji, Tianyong Sun, Shang Xie, Hua Qian, Lixiang Song, Lihua Wang, Hongwei Liu, Qiang Feng

A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein

Published: 29 July 2021 DOI: 10.1038/s41420-021-00580-3
Pengyun Li, Shengjie Cao, Yubing Huang, Yanan Zhang, Jie Liu, Xu Cai, Lulu Zhou, Jianbin Li, Zefei Jiang, Lihua Ding, Zhibing Zheng, Song Li, Qinong Ye