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FASEB Journal

IF:4.4 CiteScore:9.2 Articles:6243

The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.

Empagliflozin Downregulates AMP-Activated Protein Kinaseα O-GlcNAcylation to Ameliorate Hepatic Steatosis

Published: 22 October 2025 DOI: 10.1096/fj.202500538RR
Yicheng Zhou, MinXuan Xu, Piaojian Yu, Wei Wang, Lidan Cheng, Xiaojuan Jiao, Qin Zhang, Haixia Xiong, Peng Yu, Yanming Chen, Fen Xu, Yunfeng Shen

EDIL3 Deficiency Attenuates Liver Fibrosis Through Inhibiting Hepatic Stellate Cells Activation via the Integrin αvβ3-ERK1/2-RUNX2 Axis in MASH Mice

Published: 23 July 2025 DOI: 10.1096/fj.202403088R
Cheng Wei, Dongwei Lu, Jianfang Liu, Juan-Juan Qin, Menglong Wang, Fang Lei

Hypoxia Exposure Promotes Th17 Cell Differentiation Through Activin A-PKM2 Axis to Exacerbate Autoimmune and Autoinflammatory Diseases

Published: 14 June 2025 DOI: 10.1096/fj.202500719R
Yuhui Li, Mengting He, Jie Xu, Jiayao Liu, Chenxi Xiao, Yajie Hu, Honghong Chen, Jun Chang, Xinhua Liu

Rescue of Epilepsy‐Associated Mutations of the Highly Conserved Glycine Residue 443 in the Human GABA Transporter 1

Published: 9 June 2025 DOI: 10.1096/fj.202403159RR
Nikita Shah, Vasylyna Kovalchuk, Rocco Zerlotti, Kim Cole, Andre Bazzone, Harald H. Sitte, Thomas Hummel, Ameya S. Kasture, Sonja Sucic

Identification of CDKN1A as a potential key risk factor in MASLD progression

Published: 11 April 2025 DOI: 10.1096/fj.202402942R
Lijuan Deng, Jianxin Deng, Liping Luo, Hongjia Yang, Mengxue Sun, Yucheng Gao, Qing Liu, Ebenezeri Erasto Ngowi, Yinghua Zhou, Rongrong Zhang, Xiaojun Liu, Aijun Qiao

Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway

Published: 6 January 2025 DOI: 10.1096/fj.202402134RR
Jie Tang, Wenqiang Liu, Zihan Li, Can Shen, Longbiao Zhang, Cheng Wang, Fengshuo Wang, Zhuoyan Zai, Xuewen Qian, Weirong Hu, Xiaoyue Zhang, Xiaoqing Peng, Yayun Xu, Feihu Chen

Arginine demethylation of Serine/Arginine-rich splicing factor 1 enhances miRNA enrichment in small extracellular vesicles derived from pancreatic ductal adenocarcinoma cells

Published: 6 January 2025 DOI: 10.1096/fj.202401811RR
Kritisha Bhandari, Jeng Shi Kong, Wang-Ting Tina Ho, Philip C. Bourne, Blaine H. M. Mooers, Wei-Qun Ding

Myeloid‐derived suppressor cells inhibit responses of T follicular helper cells during experimental Plasmodium yoelii infection

Published: 4 December 2024 DOI: 10.1096/fj.202401237R
Lengshan Mo, Cansheng Hong, Zhihan Jiang, Yiqiang Zhu, Lu Zhou, Simin Tan, Guorong Deng, Yanwei Qi, Tengfei Hu, Qianlian Wu, Yi Zhao, Huaina Qiu, Taizhen Liang, Peibin Lin, Jian Zhang, Xiancai Ma, Quan Yang

Bergenin, the main active ingredient of Bergenia purpurascens, attenuates Th17 cell differentiation by downregulating fatty acid synthesis

Published: 7 October 2024 DOI: 10.1096/fj.202400961R
Yue He, Danlei Xu, Jing Zhang, Yan Liu, Minghui Liao, Yufeng Xia, Zhifeng Wei, Yue Dai

Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures

Published: 4 September 2024 DOI: 10.1096/fj.202400870R
Chuanxin Sun, Juan Su, Jiarui Wang, Kan Ding, Chang Chen

Scutellarin alleviates renal ischemia–reperfusion injury by inhibiting the MAPK pathway and pro-inflammatory macrophage polarization

Published: 3 July 2024 DOI: 10.1096/fj.202302243R
Ge Deng, Bingxuan Zheng, Meng Dou, Yang Gao, Xingzhe Zhang, Zejiaxin Niu, Tian Wei, Feng Han, Chenguang Ding, Puxun Tian

TRIM26 restricts Epstein–Barr virus infection in nasopharyngeal epithelial cells through K48-linked ubiquitination of HSP-90β

Published: 1 December 2023 DOI: 10.1096/fj.202300929RR
Mingjiao Zhang, Haiqi Tan, Yibing Gong, Oluwasijibomi Damola Faleti, Dengke Li, Jinlong Yang, Jing Huang, Jingyi Long, Qingshuang Luo, Gongfa Wu, Lei Zheng, Xiaoming Lyu

Alteration of cholesterol content and oxygen level in intestinal organoids after infection with Staphylococcus aureus

Published: 30 October 2023 DOI: 10.1096/fj.202300799r
AhmedElmontaser Mergani, Marita Meurer, Elena Wiebe, Katrin Dümmer, Katrin Wirz, Judith Lehmann, Graham Brogden, Maren Schenke, Katrin Künnemann, Hassan Y. Naim, Guntram A. Grassl, Maren von Köckritz-Blickwede, Bettina Seeger

MAP-2:CD55 chimeric construct effectively modulates complement activation

Published: 12 October 2023 DOI: 10.1096/fj.202300571R
Lydia González-del-Barrio, Laura Pérez-Alós, Leon Cyranka, Anne Rosbjerg, Simon Nagy, Zoltán Prohászka, Peter Garred, Rafael Bayarri-Olmos

Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury.

Published: 12 April 2023 DOI: 10.1096/fj.202201765R
Qiuling Liu, Tujing Song, Bing Chen, Jingjing Zhang, Wen Li

Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1

Published: 27 April 2022 DOI: 10.1096/fj.202101914RR
Mengying Zhu, Hui Wang, Yiluan Ding, Yuanyuan Yang, Zhuo Xu, Li Shi, Naixia Zhang

Gemcitabine synergizes with cisplatin to inhibit nasopharyngeal carcinoma cell proliferation and tumor growth

Published: 1 October 2021 DOI: 10.1096/fj.202100076RR
Shi-Wei He, Yuan Zhang, Lei Chen, Wei-Jie Luo, Xiao-Min Li, Yang Chen, Sheng-Yan Huang, Qing-Mei He, Xiao-Jing Yang, Ying-Qin Li, Na Liu, Yin Zhao, Jun Ma

Cf-02, a novel benzamide-linked small molecule, blunts NF-κB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe lupus nephritis in mice

Published: 1 August 2021 DOI: 10.1096/fj.202100047R
Shin-Ruen Yang, Kuo-Feng Hua, Chih-Yu Yang, Ann Chen, Jui-Chun Weng, Yu-Ling Tsai, Chih-Jun Wan, Chung-Yao Wu, Chia-Chung Lee, Jia-Feng Chan, Chih-Yu Hsieh, Yu-Juei Hsu, Chia-Chao Wu, Debabrata Mukhopadhyay, Hsu-Shan Huang, Feng-Cheng Liu, Shuk-Man Ka

GPA peptide enhances Nur77 expression in intestinal epithelial cells to exert a protective effect against DSS-induced colitis

Published: 25 September 2020 DOI:
Zhao Deng, Liufeng Zheng, Xiaowei Xie, Hongkui Wei, Jian Peng

MicroRNA‐182 exacerbates blood‐brain barrier (BBB) disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia

Published: 17 August 2020 DOI: 10.1096/fj.201903092r
Tongshuai Zhang, Chao Tian, Jinrong Wu, Yao Zhang, Jinghua Wang, Qingfei Kong, Lili Mu, Bo Sun, Tianhong Ai, Yue Wang, Wei Zhao, Dandan Wang, Hulun Li, Guangyou Wang

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