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Immunity

IF:26.3 CiteScore:49.4 Articles:205

Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

Published: 17 July 2025 DOI: 10.1016/j.immuni.2025.06.017
Marco Di Gioia, Valentina Poli, Piao J. Tan, Roberto Spreafico, Anne Chu, Alex G. Cuenca, Zhongyang Wu, Mehdi Benamar, Laura Pandolfi, Federica Meloni, Fatemeh Askarian, Jason Hsiao, Elizaveata Borroum, Victor Nizet, Philip L.S.M. Gordts, Joseph L. Witztum, Talal A. Chatila, Janet Chou, Xu Zhou, James R. Springstead, Ivan Zanoni

Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo

Published: 16 June 2025 DOI: 10.1016/j.immuni.2025.05.018
Xiuli Yang, Wenxiang Ding, Fangzhou Lou, Hao Xu, Anqi Sheng, Yang Sun, Xiaojie Cai, Miaoni Zhou, Fuquan Lin, Rong Jin, Xichen Zheng, Zhikai Wang, Siyu Deng, Zhenyao Xu, Taiyu Zhang, Jinke Cheng, Xingdong Zheng, Aie Xu, Honglin Wang

Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity

Published: 14 November 2023 DOI: 10.1016/j.immuni.2023.09.012
Chunyuan Zhao, Yunjin Ma, Minghui Zhang, Xiaoyan Gao, Wenbo Liang, Ying Qin, Yue Fu, Mutian Jia, Hui Song, Chengjiang Gao, Wei Zhao

SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing

Published: 14 November 2023 DOI: 10.1016/j.immuni.2023.10.001
Yanfei Hou, Zhimeng Wang, Peiyuan Liu, Xubiao Wei, Zhengyin Zhang, Shilong Fan, Lulu Zhang, Fangping Han, Yikang Song, Ling Chu, Conggang Zhang

Renal NF-κB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting

Published: 13 September 2022 DOI: 10.1016/j.immuni.2022.07.022
Yuchen Chen, Wenhao Xu, Yuan Chen, Anxuan Han, Jiantao Song, Xiaoya Zhou, Wei Song

Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in?vivo.

Published: 12 October 2021 DOI: 10.1016/j.immuni.2021.08.027
Yuan Fang, Zezhong Liu, Yang Qiu, Jing Kong, Yuhong Fu, Yujie Liu, Chong Wang, Jia Quan, Qian Wang, Wei Xu, Lei Yin, Jie Cui, Yi Xu, Stephen Curry, Shibo Jiang, Lu Lu, Xi Zhou

Multiomics analyses reveal a critical role of selenium in controlling T?cell differentiation in Crohn’s disease

Published: 10 August 2021 DOI: 10.1016/j.immuni.2021.07.004
Ling-Jie Huang, Xin-Tao Mao, Yi-Yuan Li, Dan-Dan Liu, Ke-Qi Fan, Rong-Bei Liu, Ting-Ting Wu, Hao-Li Wang, Yu Zhang, Bing Yang, Cun-Qi Ye, Jiang-Yan Zhong, Ren-Jie Chai, Qian Cao, Jin Jin

Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation

Published: 14 April 2020 DOI: 10.1016/j.immuni.2020.03.003
Fotios Karagiannis, Schekufe Kharabi Masouleh, Klaus Wunderling, Jayagopi Surendar, Vanessa Schmitt, Alexander Kazakov, Marcel Michla, Michael Hölzel, Christoph Thiele, Christoph Wilhelm

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Published: 17 April 2018 DOI: 10.1016/j.immuni.2018.03.017
Chenguang Wang, Yukun Guan, Mengze Lv, Rui Zhang, Zhaoying Guo, Xiaoming Wei, Xiaoxia Du, Jing Yang, Tong Li, Yi Wan, Xiaodong Su, Xiaojun Huang, Zhengfan Jiang