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Molecules

IF:4.2 CiteScore:7.4 Articles:7524

Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.

Bufalin Suppresses Colorectal Cancer Liver Metastasis by Inhibiting De Novo Fatty Acid Synthesis via the PI3K/AKT-Mediated SREBP1/FASN Pathway

Published: 5 September 2025 DOI: 10.3390/molecules30173634
Wenwen Pang, Xiang Li, Suying Yan, Junshi Zhang, Ping Wu, Haiyang Yu, Bowei Zhang, Chunze Zhang

Virtual Screening of Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and In Vitro Validation

Published: 17 April 2025 DOI: 10.3390/molecules30081815
Zhengwan Huang, Zhengang Peng, Dandan Huang, Zhongyu Zhou

Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors

Published: 15 February 2025 DOI: 10.3390/molecules30040904
Wen Luo, Zilu Pan, Xinyuan Zhu, Yan Li, Yong Li, Yudi Zhang, Jiamin Pan, Jian Ding, Hua Xie, Guilong Zhao

Identification of Novel PPARγ Partial Agonists Based on Virtual Screening Strategy: In Silico and In Vitro Experimental Validation

Published: 15 October 2024 DOI: 10.3390/molecules29204881
Yu-E Lian, Mei Wang, Lei Ma, Wei Yi, Siyan Liao, Hui Gao, Zhi Zhou

Stability Evaluation and Pharmacokinetic Profiling of Vepdegestrant in Rodents Using Liquid Chromatography–Tandem Mass Spectrometry

Published: 27 August 2024 DOI: 10.3390/molecules29174048
Hae-In Choi, Jinyoung Choi, Jin Woo Kim, Yoon Ha Lee, Kwan Hyung Cho, Tae-Sung Koo

Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells

Published: 18 January 2024 DOI: 10.3390/molecules29020482
Yong Hwan Kim, Na Yeon Park, Doo Sin Jo, Ji-Eun Bae, Joon Bum Kim, Kyuhee Park, Kwiwan Jeong, Pansoo Kim, Eunbyul Yeom, Dong-Hyung Cho

Solubility and Thermodynamics Data of Cabozantinib Malate in Various Aqueous Solutions of Dimethyl Sulfoxide at Different Temperatures.

Published: 27 November 2023 DOI: 10.3390/molecules28237805
Faiyaz Shakeel, Nazrul Haq, Sultan Alshehri, Ibrahim A Alsarra

Chromium Picolinate Protects against Testicular Damage in STZ-Induced Diabetic Rats via Anti-Inflammation, Anti-Oxidation, Inhibiting Apoptosis, and Regulating the TGF-β1/Smad Pathway

Published: 20 November 2023 DOI: 10.3390/molecules28227669
Hongxing Zheng, Yingjun Hu, Mengli Shao, Simin Chen, Shanshan Qi

A UPLC-MS/MS Based Rapid, Sensitive, and Non-Enzymatic Methodology for Quantitation of Dietary Isoflavones in Biological Fluids

Published: 21 September 2023 DOI: 10.3390/molecules28186729
Faraz Rashid, Sudeep Ghimire, Ashutosh K Mangalam, Shailendra Giri

Meldrum's Acid Furfural Conjugate MAFC: A New Entry as Chromogenic Sensor for Specific Amine Identification.

Published: 14 September 2023 DOI: 10.3390/molecules28186627
Lisa Zeußel, Sukhdeep Singh

Chiral Recognition of D/L-Ribose by Visual and SERS Assessments.

Published: 7 September 2023 DOI: 10.3390/molecules28186480
Guohua Yao, Chao Liu, Shereen M Elsherbiny, Qing Huang

Triterpenoid and Coumarin Isolated from Astilbe grandis with Anti-Inflammatory Effects through Inhibiting the NF-κB Pathway in LPS-Induced RAW264.7 Cells

Published: 28 July 2023 DOI: 10.3390/molecules28155731
Jin-Fang Luo, Lan Yue, Tian-Tai Wu, Chen-Liang Zhao, Jiang-Hai Ye, Kang He, Juan Zou

Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells

Published: 3 March 2023 DOI: 10.3390/molecules28052358
Ya-Fen Hsu, Fan-Lu Kung, Tzu-En Huang, Yi-Ning Deng, Jih-Hwa Guh, Paolo Marchetti, Elena Marchesi, Daniela Perrone, Maria Luisa Navacchia, Lih-Ching Hsu

Resveratrol, a New Allosteric Effector of Hemoglobin, Enhances Oxygen Supply Efficiency and Improves Adaption to Acute Severe Hypoxia

Published: 22 February 2023 DOI: 10.3390/molecules28052050
Zongtang Chu, Weidan Li, Guoxing You, Yuzhi Chen, Dong Qin, Peilin Shu, Yujing Wang, Ying Wang, Lian Zhao, Hong Zhou

The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung Adenocarcinoma and Its Potential as a Therapeutic Target

Published: 22 January 2023 DOI: 10.3390/molecules28031103
Lei Hu, Yu Liu, Changfang Fu, Jiarong Zhao, Qianwen Cui, Qiuyan Sun, Hongqiang Wang, Li Lu, Haiming Dai, Xiaohui Xu, Wulin Yang

Dess-Martin Periodinane-Mediated Oxidative Coupling Reaction of Isoquinoline with Benzyl Bromide.

Published: 17 January 2023 DOI: 10.3390/molecules28030923
Chunmei Yang, Guoqing Zhang, Senling Tang, Yang Pan, Huawu Shao, Wei Jiao

Cepharanthine Ameliorates Pulmonary Fibrosis by Inhibiting the NF-κB/NLRP3 Pathway, Fibroblast-to-Myofibroblast Transition and Inflammation

Published: 11 January 2023 DOI: 10.3390/molecules28020753
Guangrui Chen, Jian Li, Huimeng Liu, Huiyu Zhou, Mingqiu Liu, Di Liang, Zhiyun Meng, Hui Gan, Zhuona Wu, Xiaoxia Zhu, Peng Han, Taoyun Liu, Ruolan Gu, Shuchen Liu, Guifang Dou

Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases.

Published: 9 December 2022 DOI: 10.3390/molecules27248732
Yan He, Yi Wang, Kun Yang, Jia Jiao, Hong Zhan, Youjun Yang, De Lv, Weihong Li, Weijun Ding

A Review on Polyacrylonitrile as an Effective and Economic Constituent of Adsorbents for Wastewater Treatment.

Published: 8 December 2022 DOI: 10.3390/molecules27248689
Archana Gupta, Vishal Sharma, Pawan Kumar Mishra, Adam Ekielski

Identification of Estradiol Benzoate as an Inhibitor of HBx Using Inducible Stably Transfected HepG2 Cells Expressing HiBiT Tagged HBx

Published: 6 August 2022 DOI: 10.3390/molecules27155000
Jingjing He, Jingwen Wu, Jingwen Chen, Shenyan Zhang, Yifei Guo, Xueyun Zhang, Jiajia Han, Yao Zhang, Yue Guo, Yanxue Lin, Weien Yu, Yide Kong, Zhongliang Shen, Richeng Mao, Jiming Zhang

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