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Nature Communications

IF:14.7 CiteScore:24.9 Articles:6928

Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.

FAD synthase confers ferroptosis resistance and restrains CD8+ T cell recruitment in hepatocellular carcinoma

Published: 29 October 2025 DOI: 10.1038/s41467-025-64572-y
Jiashuo Chao, Yuan Liang, Hao Wang, Ziyu Xun, Shanshan Wang, Zhengfeng Xuan, Mingming Wang, Qiyuan Huang, Rui Zhang, Mu Liu, Lei Zhang, Bohang Shou, Yuhan Zhang, Feng Cheng, Haitao Zhao, Ling Lu

Structural mechanism of the agonist binding on human TRPC3 channel

Published: 22 October 2025 DOI: 10.1038/s41467-025-64435-6
Yikun Chen,Jiahe Zang,Wenjun Guo,Jiaxuan Xu,Miao Wei,Li Quan,Min Zhu,Xiaole Zhao,Hailin Peng,Yakun Wan,Lei Chen

Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes

Published: 13 October 2025 DOI: 10.1038/s41467-025-64149-9
Chuqi Liu, Dexiang Liu, Xiang Zheng, Jiali Guan, Xinyan Zhou, Haikun Zhang, Shen Wang, Qiubai Li, Gan Lu, Jun He, Cong Ma

Cytoplasmic TRIM24 promotes colorectal cancer cell proliferation by activating Wnt/β-catenin signaling

Published: 29 September 2025 DOI: 10.1038/s41467-025-63685-8
Ya Wang,Yuanbing Yao,Zehong Liu,Shichao Long,Feng Yi,Qing Fang,Dongbo Wu,Qing Zhu,Hongyan Zai,Shuai Xiao,Fengyi Wan,Kai Fu

Targeting ALDH16A1 mediated thioredoxin lysosomal degradation to enhance ferroptosis susceptibility in SMARCA4-deficient NSCLC

Published: 2 September 2025 DOI: 10.1038/s41467-025-63687-6
Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Shencheng Ren, Haochun Shi, Xiaolong Huang, Junkan Zhu, Qun Wang, Wei Jiang, Boyi Gan, Cheng Zhan

Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice

Published: 30 August 2025 DOI: 10.1038/s41467-025-63456-5
Shunyi Lu, Jie Cao, Zhuorun Song, Fei Gong, Peng Yang, Jun Ge, Yunfei He, Zhihui Han, Guanghui Hou, Zimin Zhang, Yuqi Yang, Yun Teng, Zengli Zhang, Jun Zou, Liang Cheng, Huilin Yang

Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors

Published: 23 August 2025 DOI: 10.1038/s41467-025-63039-4
Chenhui Zhao, Xueyan Hu, Xiudong Guan, Xiaojun Fu, Tingting Wang, Mengyuan Li, Xinze Liu, Jiarui Zhao, Di Wu, Fan Zhang, Jiaying Fu, Jiang Li, Tieqiang Zhang, Xiaochun Jiang, Changxiang Yan, Wang Jia, Ence Yang, Jian Chen

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

Published: 21 August 2025 DOI: 10.1038/s41467-025-63125-7
Xin Zhou, Miesje M van der Stoel, Shreyas Kaptan, Haoran Li, Shiqian Li, Maarit Hölttä, Helena Vihinen, Eija Jokitalo, Christoph Thiele, Olli Pietiläinen, Shin Morioka, Junko Sasaki, Takehiko Sasaki, Ilpo Vattulainen, Elina Ikonen

OFD1 inhibition induces BRCAness to create a therapeutic vulnerability to PARP inhibition in pancreatic cancer

Published: 5 August 2025 DOI: 10.1038/s41467-025-62295-8
Peng Li, Junjie Ye, Qian Yang, Ni Wang, Chaoyi Li, Xiaoxiao Zou, Hanyan Luo, Yi Pan, Lingxi Jiang, Baiyong Shen, Zaiming Tang, Qing Zhong

Structure and mechanism of the RalGAP tumor suppressor complex

Published: 30 July 2025 DOI: 10.1038/s41467-025-61743-9
René Rasche, Björn Udo Klink, Lisa Helene Apken, Esther Michalke, Minghao Chen, Andrea Oeckinghaus, Christos Gatsogiannis, Daniel Kümmel

AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progression

Published: 29 July 2025 DOI: 10.1038/s41467-025-62381-x
Qiaohua Wang, Yongjian Wu, Yili Long, Rongna Li, Yu Shi, Yanfen Zheng, Xiaohui Chen, Xiang Li, Yihong Zhou, Xi Huang, Guanmin Jiang

Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking

Published: 25 July 2025 DOI: 10.1038/s41467-025-62188-w
Manqing Wu, Miaojun Lai, Yiyin Zhou, Yingjie Cheng, Sai Shi, Fangmin Wang, Huizhen Liu, Min Zhao, Wenhua Zhou

Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities

Published: 24 July 2025 DOI: 10.1038/s41467-025-62131-z
Wanqian Li, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang

Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 and inducing mitochondrial dysfunction

Published: 19 July 2025 DOI: 10.1038/s41467-025-61901-z
Xue Han,Ruyi Zheng,Jiajia Zhang,Yanan Liu,Ze Li,Guoxuan Liu,Jianing Zheng,Weiqi Li,Zijun Liang,Mengyang Wang,Jie Yu,Qiaojuan Shi,Huazhong Ying,Guang Liang

Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors

Published: 14 July 2025 DOI: 10.1038/s41467-025-61695-0
Yixuan Zhong, Huihui Tao, Yu Zhang, Binbin He, Haizhan Jiao, Dandan Wang, Maikun Teng, Hongli Hu, Qiong Guo, Yuyong Tao

Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age

Published: 7 July 2025 DOI: 10.1038/s41467-025-60975-z
Sahil A. Mapkar, Sarah A. Bliss, Edgar E. Perez Carbajal, Sean H. Murray, Zhiru Li, Anna K. Wilson, Vikrant Piprode, You Jin Lee, Thorsten Kirsch, Katerina S. Petroff, Fengyuan Liu, Michael N. Wosczyna

YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer in mice

Published: 7 July 2025 DOI: 10.1038/s41467-025-61560-0
Wenchao Li, SaiSai Chen, Jian Lu, Weipu Mao, Shiya Zheng, Minhao Zhang, Tiange Wu, Yurui Chen, Kai Lu, Chunyan Chu, Chuanjun Shu, Yue Hou, Xue Yang, Naipeng Shi, Zhijun Chen, Lihua Zhang, Lei Zhang, Rong Na, Ming Chen, Shenghong Ju, Dingxiao Zhang, Yi Ma, Bin Xu

Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity

Published: 4 July 2025 DOI: 10.1038/s41467-025-60971-3
Adrián Varela-Vázquez, Amanda Guitián-Caamaño, Paula Carpintero-Fernández, Alexander Carneiro-Figueira, Vanesa Álvarez, Marta Varela-Eirín, Teresa Calleja-Chuclá, Susana B Bravo-López, Anxo Vidal, Juan Sendón-Lago, Marina Rodriguez-Candela Mateos, José R Caeiro, Victoria Sanz-Moreno, Trond Aasen, Miguel G Blanco, Guadalupe Sabio, María Quindós, Carmen Rivas, David Santamaría, Carlos Fernandez-Lozano, Eduardo Fonseca, Pablo Huertas, Berta Sánchez-Laorden, Constance Alabert, María D Mayán

Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression

Published: 1 July 2025 DOI: 10.1038/s41467-025-61088-3
Lixia Cao, Wei Sun, Xiao Chen, Lei Liu, Shaorong Zhao, Jingjing Liu, Yang Ou, Min Guo, Chunchun Qi, Zhaoxian Li, Jie Shi, Yuxin Liu, Qiuying Shuai, Siyu Zuo, Huayu Hu, Tianwen Yu, Yanjing Wang, Mengdan Feng, Jianying Lv, Hang Wang, Peiqing Sun, Jin Zhang, Longlong Wang, Yi Shi, Shuang Yang

Viruses hijack FPN1 to disrupt iron withholding and suppress host defense

Published: 1 July 2025 DOI: 10.1038/s41467-025-60031-w
Li Tong, Jie Wang, Yunjin Ma, Chunying Wang, Yue Fu, Qi Li, Chengjiang Gao, Hui Song, Ying Qin, Chunyuan Zhao, Wei Zhao

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