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Oncogene

IF:7.3 CiteScore:15.3 Articles:404

Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.

RCN3 functions as a tumor promoter in colorectal cancer by modulating the GRP78-PI3K-AKT signaling pathway

Published: 23 August 2025 DOI: 10.1038/s41388-025-03535-5
Mei Huang, Bingru Qin, Zhefan Xie, Ruling Zhou, Zhizhao Lin, Lihua Zhou, Zelong Han, Side Liu, Kangmin Zhuang

TLL1 knockdown attenuates prostate cancer progression by enhancing antitumor immunity

Published: 4 August 2025 DOI: 10.1038/s41388-025-03517-7
Jing-Lan Hao, Jia-Qi He, Hang Hu, Zi-Heng Zhu, Xi Zhao, Xiao-Yu Wu, Lan Li, Yong-Tong Ruan, Juan Yang, Xin-Yi Luo, Wang-Xue Xu, Ming Fu, Kai Zhang, Ping Gao, Xiao-Ming Dong

REPS2 attenuates cancer stemness through inhibiting Wnt signaling by autophagy mediated degradation of β-catenin

Published: 13 June 2025 DOI: 10.1038/s41388-025-03469-y
Lu Liu, Shuzhen Chen, Yuxi Lei, Zejian Lin, Rulan Zhou, Guandi Zeng, Zongyao Zheng, Wanting Liu, Qian Zhou, Liang Chen

Cancer-associated loss-of-function mutations in KCNQ1 enhance Wnt/β-catenin signalling disrupting epithelial homeostasis

Published: 23 May 2025 DOI: 10.1038/s41388-025-03447-4
Camille Berenguier, Xingyu Chen, Benoit Allegrini, Hélène Guizouarn, Franck Borgese, Catherine Etchebest, Olivier Soriani, Raphael Rapetti-Mauss

TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma

Published: 10 December 2024 DOI: 10.1038/s41388-024-03244-5
Shuwei Zhang, Yan Qin Tan, Xi Zhang, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

LINC00882, transcriptionally activated by CEBP-β and post-transcriptionally stabilized by METTL14-mediated m6A modification, exerts tumorigenesis by promoting PABPC1-mediated stabilization of ELK3 mRNA

Published: 17 November 2024 DOI:
Zhao-Xin Gao, Chun-Lan Li, Han Zhang, Guo-Hao Zhang, Yu Zhang, Xiang-Yu Guo, Zhi-Yuan Tang, Peng Gao, Hai-Ting Liu

TMSB4Y restrains sphingomyelin synthesis via de novo purine synthesis to exert a tumor suppressor function in male esophageal squamous cell carcinoma

Published: 23 October 2024 DOI: 10.1038/s41388-024-03193-z
Tongyang Gong, Wanyuan Sun, Xukun Li, Jiahui Cai, Ning Zhao, Minyi Lu, Juan Xu, Zhihua Liu, Hongyan Chen

Alternative splicing of ALDOA confers tamoxifen resistance in breast cancer

Published: 20 August 2024 DOI: 10.1038/s41388-024-03134-w
Shiyi Yu, Rui Wu, Yue Si, Zhehao Fan, Ying Wang, Chang Yao, Rongmao Sun, Yaji Xue, Yongli Chen, Zheng Wang, Shuangshuang Dong, Ning Wang, Xinyue Ling, Zhengyan Liang, Caili Bi, Yi Yang, Weibing Dong, Haibo Sun

N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance

Published: 24 June 2024 DOI: 10.1038/s41388-024-03092-3
Ming-Jian Ma, Yin-Hao Shi, Zhi-De Liu, Ying-Qin Zhu, Guang-Yin Zhao, Jing-Yuan Ye, Fu-Xi Li, Xi-Tai Huang, Xi-Yu Wang, Jie-Qin Wang, Qiong-Cong Xu, Xiao-Yu Yin

METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4

Published: 15 June 2024 DOI: 10.1038/s41388-024-03085-2
Yichen Zang, Zhuangfei Tian, Dandan Wang, Yaxuan Li, Wenhui Zhang, Cunying Ma, Zhenzhi Liao, Wenrong Gao, Lilin Qian, Xia Xu, Jihui Jia, Zhifang Liu

O-GlcNAcylation of E3 ubiquitin ligase SKP2 promotes hepatocellular carcinoma proliferation

Published: 23 February 2024 DOI: 10.1038/s41388-024-02977-7
Zhongqi Feng, Jiaxin Yin, Zhirong Zhang, Zhen Chen, Luyi Huang, Ni Tang, Kai Wang

Stabilization of MOF (KAT8) by USP10 promotes esophageal squamous cell carcinoma proliferation and metastasis through epigenetic activation of ANXA2/Wnt signaling

Published: 5 February 2024 DOI: 10.1038/s41388-024-02955-z
Peichao Li, Lingxiao Yang, Sun Young Park, Fanrong Liu, Alex H. Li, Yilin Zhu, Huacong Sui, Fengyuan Gao, Lingbing Li, Lan Ye, Yongxin Zou, Zhongxian Tian, Yunpeng Zhao, Max Costa, Hong Sun, Xiaogang Zhao

Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide

Published: 19 January 2024 DOI:
Junhong Li, Zhe Hong, Junyu Zhang, Shengfeng Zheng, Fangning Wan, Zheng Liu, Bo Dai

Low doses of IFN-γ maintain self-renewal of leukemia stem cells in acute myeloid leukemia

Published: 23 October 2023 DOI:
Xiaoling Xie, Wuju Zhang, Xuan Zhou, Binyan Xu, Hao Wang, Yingqi Qiu, Yuxing Hu, Bin Guo, Zhixin Ye, Le Hu, Honghao Zhang, Yuhua Li, Xiaochun Bai

Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA-proficient cancer cells to PARP inhibitors

Published: 24 August 2023 DOI:
Cong Wang, Ling Tian, Qiang He, Shengbin Lin, Yue Wu, Yiting Qiao, Bo Zhu, Dake Li, Guo Chen

Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression

Published: 15 August 2023 DOI:
Tingyu Wu, Yanshuang Zhang, Qing Han, Xin Lu, Yirui Cheng, Jiachen Chen, Jianjun Sha, Weiliang Xia

E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.

Published: 7 March 2023 DOI:
Peijun Zhou, Xingzhi Peng, Siyuan Tang, Kun zhang, Zhikai Tan, Dan Li, Liangfang Shen, Jinwu Peng, Lifang Yang

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma

Published: 30 August 2022 DOI: 10.1038/s41388-022-02446-z
Tao Zhang, Jingjie Li, Mengkai Yang, Xinglong Ma, Zhuoying Wang, Xiaojun Ma, Mengxiong Sun, Wei Sun, Jing Xu, Yingqi Hua, Zhengdong Cai

PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3

Published: 29 July 2022 DOI: 10.1038/s41388-022-02418-3
Qian-Wen Zheng, Qian-Zhi Ni, Bing Zhu, Xin Liang, Ning Ma, Yi-Kang Wang, Sheng Xu, Hui-Jun Cao, Ji Xia, Feng-Kun Zhang, Er-Bin Zhang, Xiao-Song Qiu, Xu-Fen Ding, Lin Qiu, Xi-Lin Zhang, Zhao-Hui Dong, Zhi-Gang Li, Xue-Li Zhang, Dong Xie, Jing-Jing Li

PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma.

Published: 10 June 2022 DOI:
Yating Liu, Lianlian Ouyang, Chao Mao, Yuanbing Chen, Tiansheng Li, Na Liu, Zuli Wang, Weiwei Lai, Yanling Zhou, Ya Cao, Shuang Liu, Yinming Liang, Min Wang, Shouping Liu, Ling Chen, Ying Shi, Desheng Xiao, Yongguang Tao

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