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PLoS ONE

IF:2.9 CiteScore:6.2 Articles:14242

PLOS ONE is an international, peer-reviewed, open-access, online publication. PLOS ONE welcomes reports on primary research from any scientific discipline. It provides: * Open-access—freely accessible online, authors retain copyright * Fast publication times * Peer review by expert, practicing researchers * Post-publication tools to indicate quality and impact * Community-based dialogue on articles * Worldwide media coverage

Luteolin alleviates CUMS-induced depressive-like behavioral deficits in mice through blocking the JAK2/STAT3 pathway

Published: 24 October 2025 DOI: 10.1371/journal.pone.0335057
Hai-Hong Wu, Shang-Yue Chen, Dong-Liang Yuan, Ting Zhao

Alternative splicing and residual function potentially expand the therapeutic landscape of the CFTRdele2ins182 variant

Published: 16 September 2025 DOI: 10.1371/journal.pone.0330974
Cristina Pastorino, Ludovica Menta, Emanuela Pesce, Mariateresa Lena, Valeria Tomati, Valeria Capurro, Marco Di Duca, Vito Terlizzi, Andrea Gramegna, Francesco Blasi, Carlo Castellani, Serena Cappato, Federico Zara, Nicoletta Pedemonte, Renata Bocciardi

KU60019 inhibits ovarian cancer progression by targeting DGAT1/has-miR-1273g-3p axis

Published: 24 June 2025 DOI: 10.1371/journal.pone.0325213
Zhanchuan Ma, Rongjing Dang, Guodong Wu

Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma

Published: 7 May 2025 DOI: 10.1371/journal.pone.0323013
Yulou Luo, Yinghui Ye, Yilina Saibaidoula, Yuting Zhang, Yan Chen

LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis

Published: 17 January 2025 DOI: 10.1371/journal.pone.0317454
Lin Zhu, Qianqian Meng, Weiyi Qian, Weiting Shao, Yuyue Lu, Shuai Jin, Afei Zhang, Shuang G Yan, Jingtao Lu

Screening novel antiviral compounds to treat Clostridioides difficile infections

Published: 13 December 2024 DOI: 10.1371/journal.pone.0309624
Brice J Stolz, Ahmed A Abouelkhair, Mohamed N Seleem

Enhanced bacteriostasis and osseointegrative properties of SiRNA-modified polyetheretherketone surface for implant applications

Published: 5 December 2024 DOI: 10.1371/journal.pone.0314091
Zhen Liu, Libin Yang, Yazhuo Ni, Keying Chen, Qiquan Yan, Zhiying Zhao, Bo Xu, Yaoyang Li, Rui Li, Jianwen Li

Sodium-dependent glucose co-transport proteins (SGLTs) are not involved in human glucose taste detection

Published: 18 November 2024 DOI: 10.1371/journal.pone.0313128
R Kyle Palmer, Anna B Nechiporenko, Marc A Ilies, Marcel Winnig, Stephen A Gravina, Rashmi Tiwari, Indra Prakash

Cetylpyridinium chloride inhibits hepatocellular carcinoma growth and metastasis through regulating epithelial-mesenchymal transition and apoptosis

Published: 20 September 2024 DOI: 10.1371/journal.pone.0310391
Kundi Cai, Yihui Fang, Yanan Zhang, Jie Liu, Qinong Ye, Lihua Ding, Xianfeng Cai

Visfatin (NAMPT) expression in human placenta cells in normal and pathological conditions and its hormonal regulation in trophoblast JEG-3 cells

Published: 18 September 2024 DOI: 10.1371/journal.pone.0310389
Monika Dawid, Patrycja Kurowska, Piotr Pawlicki, Małgorzata Kotula–Balak, Tomasz Milewicz, Joelle Dupont, Agnieszka Rak

Evaluation of the binding interactions between Plasmodium falciparum Kelch-13 mutant recombinant proteins with artemisinin

Published: 15 August 2024 DOI: 10.1371/journal.pone.0306975
Noorazian Md Yusuf, Aisya Nazura Azman, Amirul Adli Abdul Aziz, Fazia Adyani Ahmad Fuad, Ruhayatun Naimah Nasarudin, Shamilah Hisam

PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer

Published: 17 May 2024 DOI: 10.1371/journal.pone.0300644
Yin Min Thu, Ken Suzawa, Shuta Tomida, Kosuke Ochi, Shimpei Tsudaka, Fumiaki Takatsu, Keiichi Date, Naoki Matsuda, Kazuma Iwata, Kentaro Nakata, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

(S)-(-)-blebbistatin O-benzoate has the potential to improve atopic dermatitis symptoms in NC/Nga mice by upregulating epidermal barrier function and inhibiting type 2 alarmin cytokine induction

Published: 7 May 2024 DOI: 10.1371/journal.pone.0302781
Shunya Sahara, Ayumi Ueno, Natsuki Wakita, Miki Iwai, Junki Uda, Koich Nakaoji, Kazuhiko Hamada, Akito Maeda, Yasufumi Kaneda, Manabu Fujimoto

Does amiodarone impact on apixaban levels? The effect of amiodarone on apixaban level among Thai patients with non-valvular Atrial Fibrillation.

Published: 19 January 2024 DOI: 10.1371/journal.pone.0295511
Sutee Limcharoen, Sarawuth Limprasert, Pornwalai Boonmuang, Manat Pongchaidecha, Juthathip Suphanklang, Weerayuth Saelim, Wichai Santimaleeworagun, Piyarat Pimsi

Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction

Published: 1 January 2023 DOI: 10.1371/journal.pone.0281834
Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun, Hyun Sik Na, Keun-Hyung Cho, Seok Jung Kim, Mi-La Cho, Tae-Hwe Heo

Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems

Published: 26 May 2022 DOI: 10.1371/journal.pone.0268778
Stephanie K Venn-Watson, Camden N Butterworth

Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1

Published: 16 January 2018 DOI: 10.1371/journal.pone.0191078
Wei-Ting Chen, Guan-Bo Lin, Shu-Hui Lin, Chueh-Hsuan Lu, Chih-Hsiung Hsieh, Bo-Lun Ma, Chih-Yu Chao

Ethylhexylglycerin Impairs Membrane Integrity and Enhances the Lethal Effect of Phenoxyethanol

Published: 26 October 2016 DOI: 10.1371/journal.pone.0165228
S. Langsrud, K. Steinhauer, Sonja Lüthje, K. Weber, P. Goroncy-Bermes, A. Holck

2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent

Published: 4 November 2015 DOI: 10.1371/journal.pone.0141946
M. Yokoo, Y. Kubota, K. Motoyama, T. Higashi, Masatoshi Taniyoshi, Hiroko Tokumaru, Rena Nishiyama, Y. Tabe, S. Mochinaga, A. Sato, N. Sueoka-Aragane, E. Sueoka, H. Arima, T. Irie, S. Kimura