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Toxicology

Toxicology

IF:4.8 CiteScore:7.8 Articles:222
Toxicology is an international, peer-reviewed journal that publishes only the highest quality original scientific research and critical reviews describing hypothesis-based investigations into mechanisms of toxicity associated with exposures to xenobiotic chemicals, particularly as it relates to human health. In this respect "mechanisms" is defined on both the macro (e.g. physiological, biological, kinetic, species, sex, etc.) and molecular (genomic, transcriptomic, metabolic, etc.) scale. Emphasis is placed on findings that identify novel hazards and that can be extrapolated to exposures and mechanisms that are relevant to estimating human risk. Toxicology also publishes brief communications, personal commentaries and opinion articles, as well as concise expert reviews on contemporary topics. All research and review articles published in Toxicology are subject to rigorous peer review. Authors are asked to contact the Editor-in-Chief prior to submitting review articles or commentaries for consideration for publication in Toxicology.

Drug-induced enzyme activity inhibition and CYP3A4 genetic polymorphism significantly shape the metabolic characteristics of furmonertinib

Published: 3 August 2024 DOI: 10.1016/j.tox.2024.153903
Qi Zhou , Zhize Ye , Xiaoyu Xu , Yunshan Zhong , Jianchao Luo , Zheyan Zhang , Jing Chen , Zhongxi Chen , Jianping Cai , Xiaodan Zhang , Jianchang Qian

Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress

Published: 1 December 2023 DOI: 10.1016/j.tox.2023.153674
Haiyun Li, Qian Zhang, Yi Zhang, Sida Zhang, Ruihua Zhang, Dong Chen, Jingjing Shi, Jianfu Xu, Liqin Li

Macrophage derived miR-7219–3p-containing exosomes mediate fibroblast trans-differentiation by targeting SPRY1 in silicosis

Published: 1 September 2022 DOI: 10.1016/j.tox.2022.153310
Zhiyuan Niu , Lei Wang , Xiaofeng Qin , Zhimin Ye , Bin Xie , Yongbin Hu

Enhanced GRP78 protein expression via the IRE1α/ASK1/p38 MAPK pathway during As2O3-induced endoplasmic reticulum stress in BEAS-2B cells

Published: 1 October 2021 DOI: 10.1016/j.tox.2021.152962
Jiaming Yuan , Chenjuan Yao , Jing Tang , Yingqi Liu , Chunyan Huang , Shali Yu , Haiyan Wei , Yu Han , Gang Chen

Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis

Published: 1 August 2020 DOI: 10.1016/j.tox.2020.152528
Victor Udo Nna , Godwin Adakole Ujah , Joseph Bagi Suleiman , Mahaneem Mohamed , Chukwuemeka Nwokocha , Timothy Joe Akpan , Hope Chinaza Ekuma , Victoria Victor Fubara , Catherine Barong Kekung-Asu , Eme Efiom Osim

Stavudine exposure results in developmental abnormalities by causing DNA damage, inhibiting cell proliferation and inducing apoptosis in mouse embryos

Published: 1 June 2020 DOI: 10.1016/j.tox.2020.152443
Rui-Fang Ao , Yu-Xiang Liang , Xiao-Qing Liu , Kui Tan , Xiaoling Wang , Dan Liu , Ting Zhang , Gongqin Sun , Jun Xie

Kupffer cells participate in 2-butoxyethanol-induced liver hemangiosarcomas

Published: 11 April 2010 DOI: 10.1016/j.tox.2010.02.006
Lisa M. Kamendulis, Stacy M. Corthals, James E. Klaunig

Alternative sweeteners

Published: 1 January 1988 DOI: 10.1016/0300-483X(88)90067-4
K.J. Netter