Chemical Safety Data Sheet MSDS / SDS

2-Methoxyethanol

Revision Date:2022-12-24Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 2-Methoxyethanol
  • CBnumber: CB4852791
  • CAS: 109-86-4
  • EINECS Number: 231-791-2
  • Synonyms: H2O,2-methoxyethanol

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P405 Store locked up.
P370+P378 In case of fire: Use … for extinction.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P201 Obtain special instructions before use.
Hazard statements
H373 May cause damage to organs through prolonged or repeated exposure
H370 Causes damage to organs
H360 May damage fertility or the unborn child
H332 Harmful if inhaled
H312 Harmful in contact with skin
H302 Harmful if swallowed
H226 Flammable liquid and vapour
Disposal
WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/ethylene-glycol-monomethyl-ether

SECTION 3: Composition/information on ingredients

Substance

  • Product name: 2-Methoxyethanol
  • Synonyms: H2O,2-methoxyethanol
  • CAS: 109-86-4
  • EC number: 231-791-2
  • MF: C3H8O2
  • MW: 76.09

SECTION 4: First aid measures

Description of first aid measures

General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Carbon dioxide (CO2) Foam Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air at elevated temperatures.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

1
2
1
HEALTH 1 Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride)
FIRE 2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
REACT 1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: butyl-rubber

Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Butoject? (KCL 898)

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact Material: Viton?

Minimum layer thickness: 0,7 mm Break through time: 120 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter A-(P2)

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

Exposure limits
TLV-TWA skin 5 ppm (15.5 mg/m3) (ACGIH), 25 ppm (77.5 mg/m3) (OSHA).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • AppearanceForm: clear, liquid Color: colorless
  • Odourether-like
  • Odour Threshold2,3 ppm d) pH 5,0 - 7,0 at 25 °C Melting point/freezing point Initial boiling point and boiling range Melting point/range: -85 °C - lit. 124 - 125 °C - lit. Flash point 40 °C - closed cup Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits No data available Upper explosion limit: 24,5 %(V) Lower explosion limit: 2,5 %(V) Vapour pressure 10 hPa at 20 °C Vapour density 2,63 - (Air = 1.0) Density 0,965 g/cm3 at 25 °C - lit. Relative density No data available Water solubility at 20 °C soluble Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature log Pow: -0,77 at 28 °C - Bioaccumulation is not expected., (Lit.) No data available 204 - 232 °C - Viscosity Viscosity, kinematic: 1,6 mm2/s at 20 °C Viscosity, dynamic: 1,7 mPa.s at 20 °C Explosive properties No data available Oxidizing properties No data available
  • Melting point/freezing pointMelting point/range: -85 °C - lit.
  • Initial boiling point and boiling range124 - 125 °C - lit.
  • Flash point40 °C - closed cup
  • Evaporation rate115 °F
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limits Upper explosion limit: 24,5 %(V) Lower explosion limit: 2,5 %(V)
  • Vapour pressure 10 hPa at 20 °C
  • Vapour density 2,63 - (Air = 1.0)
  • Relative density2.62 (vs air)
  • Water solubilityat 20 °C soluble
  • Partition coefficient: n-octanol/waterlog Pow: -0,77 at 28 °C - Bioaccumulation is not expected., (Lit.)
  • Autoignition temperatureNo data available
  • Decomposition temperature 204 - 232 °C -
  • ViscosityViscosity, kinematic: 1,6 mm2/s at 20 °C Viscosity, dynamic: 1,7 mPa.s at 20 °C
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available
  • Henry's Law Constant(x 10-2 atm?m3/mol): 4.41, 3.63, 11.6, 3.09, and 3.813 at 10, 15, 20, 25, and 30 °C, respectively (EPICS, Ashworth et al., 1988)
  • λmaxλ: 213 nm Amax: 1.00
    λ: 240 nm Amax: 0.20
    λ: 260 nm Amax: 0.05
    λ: 300-400 nm Amax: 0.01

Other safety information

Surface tension ca.72 mN/m at 25 °C


Relative vapor density

2,63 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Vapors may form explosive mixture with air. Vapor/air-mixtures are explosive at intense warming.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Generates dangerous gases or fumes in contact with:

Aluminum magnesium bases

Zinc

Risk of explosion with:

Oxidizing agents Air

Possible formation of:

Peroxides


Conditions to avoid

Heat. 45°C Heating.

Incompatible materials

Aluminum, various plastics

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Rabbit - 890 mg/kg
Remarks: Behavioral:General anesthetic. Blood:Other hemolysis with or withot anemia. (RTECS)
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Acute toxicity estimate Inhalation - Expert judgment - 4 h - 11 mg/l LD50 Dermal - Rabbit - 1.280 mg/kg
Remarks: (RTECS)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (Directive 67/548/EEC, Annex V, B.4.)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: slight irritation
(OECD Test Guideline 405)
Respiratory or skin sensitization
(OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Test Type: Chromosome aberration test Species: Mouse
Application Route: Oral
Method: OECD Test Guideline 475 Result: negative
Carcinogenicity
No data available
Reproductive toxicity
May damage the unborn child. May damage fertility.
Specific target organ toxicity - single exposure
Causes damage to organs. - Immune system
Specific target organ toxicity - repeated exposure
May cause damage to organs through prolonged or repeated exposure. - thymus
Aspiration hazard
No data available
Toxicity
LD50 in rats, guinea pigs (mg/kg): 2460, 950 orally (Smyth); LC50 (7 hr in air) in mice: 4.6 mg/l (Werner)

SECTION 12: Ecological information

Toxicity

Toxicity to fish
static test LC50 - Lepomis macrochirus (Bluegill sunfish) - > 10.000 mg/l - 96 h

(OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

semi-static test EC50 - Daphnia magna (Water flea) - 27.000 mg/l - 48 h

(ISO 6341)

Toxicity to algae
static test ErC50 - Pseudokirchneriella subcapitata (green algae) -

25.500 mg/l - 72 h (ISO 8692)

Toxicity to bacteria
static test EC50 - activated sludge - > 1.000 mg/l - 3 h (OECD Test Guideline 209)

Persistence and degradability

Biodegradability aerobic - Exposure time 20 d

Result: 88 % - Readily biodegradable. Remarks: (ECHA)


Bioaccumulative potential

No bioaccumulation is to be expected (log Pow <= 4).

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and

containers, or contact us there if you have further questions.

Incompatibilities

Vapors may form explosive mixture with air. Heat or oxidizers may cause the formation of unstable peroxides. Attacks many metals. Strong oxidizers may cause fire and explosions. Strong bases cause decomposition and the formation of toxic gas. Attacks some plastics, rubber and coatings. May accumulate static electrical charges, and may cause ignition of its vapors.

Waste Disposal

Concentrated waste containing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.

SECTION 14: Transport information

UN number

ADR/RID: 1188 IMDG: 1188 IATA: 1188

UN proper shipping name


ADR/RID: ETHYLENE GLYCOL MONOMETHYL ETHER IMDG: ETHYLENE GLYCOL MONOMETHYL ETHER


IATA: Ethylene glycol monomethyl ether

14.3

Transport hazard class(es)

ADR/RID: 3 IMDG: 3


IATA: 3

14.4

Packaging group

ADR/RID: III IMDG: III


IATA: III

14.5

Environmental hazards

ADR/RID: yes IMDG Marine pollutant: yes


IATA: no

14.6

Special precautions for user

No data available


SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/
EC Inventory:Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is indicated.The odour warning when the exposure limit value is exceeded is insufficient.Check for peroxides prior to distillation; eliminate if found.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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