Chemical Safety Data Sheet MSDS / SDS

2-Ethoxyethanol

Revision Date:2022-12-24Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 2-Ethoxyethanol
  • CBnumber: CB6852821
  • CAS: 110-80-5
  • EINECS Number: 203-804-1
  • Synonyms: 2-ethoxyethanol,Ethyl Glycol

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P311 Call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
Hazard statements
H226 Flammable liquid and vapour
H302 Harmful if swallowed
H331 Toxic if inhaled
H360 May damage fertility or the unborn child
Disposal
WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/ethylene-glycol-monoethyl-ether

SECTION 3: Composition/information on ingredients

Substance

  • Product name: 2-Ethoxyethanol
  • Synonyms: 2-ethoxyethanol,Ethyl Glycol
  • CAS: 110-80-5
  • EC number: 203-804-1
  • MF: C4H10O2
  • MW: 90.12

SECTION 4: First aid measures

Description of first aid measures

General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Dry powder Dry sand
Unsuitable extinguishing media
Do NOT use water jet.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

Use water spray to cool unopened containers.

NFPA 704

2
2
0
HEALTH 2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE 2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.

For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations (see section 13).

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Avoid exposure - obtain special instructions before use. Advice on safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.

Advice on protection against fire and explosion

Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.

Hygiene measures

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: butyl-rubber

Minimum layer thickness: 0,3 mm Break through time: 480 min

Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,4 mm Break through time: 99 min

Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Exposure limits
TLV-TWA skin 5 ppm (18.5 mg/m3) (ACGIH). .

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • AppearanceForm: liquid Color: colorless
  • Odourether-like
  • Odour Threshold0.58ppm
  • pHat 20 °C neutral
  • Melting point/freezing pointMelting point/range: -90 °C - lit.
  • Initial boiling point and boiling range135 °C - lit.
  • Flash pointca.40 °C at ca.1.013 hPa - closed cup
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limits Upper explosion limit: 14 %(V) Lower explosion limit: 1,8 %(V)
  • Vapour pressure 7,51 hPa at 25 °C
  • Vapour density 3,1
  • Relative density0,93 g/mL at 25 °C - lit. No data available
  • Water solubilityat 20 °C soluble
  • Partition coefficient: n-octanol/waterlog Pow: 0,32 - Bioaccumulation is not expected., (ECHA)
  • Autoignition temperature235 °C at 1.013 hPa
  • Decomposition temperatureNo data available
  • ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available
  • λmaxλ: 215 nm Amax: 1.00
    λ: 225 nm Amax: 0.50
    λ: 250 nm Amax: 0.20
    λ: 305 nm Amax: 0.01

Other safety information

Solubility in other solvents

Methanol at 20 °C

  • soluble Ether at 20 °C

  • soluble

Dissociation constant 14,8

Relative vapor density

3,1

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

Heat, flames and sparks.

Incompatible materials

Oxidizing agents, Copper

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Guinea pig - male and female - 1.400 mg/kg Remarks: (Regulation (EC) No 1272/2008, Annex VI) (ECHA)
LC50 Inhalation - Rat - female - 4 h - 14,72 mg/l (Calculation method)
Remarks: (ECHA)
(Regulation (EC) No 1272/2008, Annex VI) LD50 Dermal - Rabbit - male - 3.271 mg/kg Remarks: (ECHA)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: slight irritation - 1 h (Draize Test)
Respiratory or skin sensitization
(OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (National Toxicology Program)
Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation Result: Positive results were obtained in some in vitro tests. Remarks: (National Toxicology Program)
Test Type: Chromosome aberration test in vitro Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: positive
Remarks: (National Toxicology Program)
Test Type: In vivo micronucleus test Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection
Result: negative Remarks: (ECHA)
Carcinogenicity
No data available
Reproductive toxicity
May damage the unborn child. May damage fertility.
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Toxicity
Acute oral LD50 for guinea pigs 1,400 mg/kg, mice 2,451 mg/kg, rats 3,000 mg/kg, rabbits 3,100 mg/kg (quoted, RTECS, 1985).

SECTION 12: Ecological information

Toxicity

Toxicity to fish
static test LC50 - Lepomis macrochirus (Bluegill sunfish) - > 10.000 mg/l - 96 h

Remarks: (ECHA)


Toxicity to daphnia and other aquatic

EC50 - Daphnia - 1.892,52 mg/l - 48 h Remarks: (ECOTOX Database)

invertebrates

Toxicity to algae
static test NOEC - Desmodesmus subspicatus (green algae) - >=

1.000 mg/l - 72 h Remarks: (ECHA)


Persistence and degradability

Biodegradability aerobic - Exposure time 14 d

Result: 63 - 83 % - Readily biodegradable. (OECD Test Guideline 301C)

Biochemical Oxygen Demand (BOD)

Chemical Oxygen Demand (COD)

Theoretical oxygen demand

1.100 mg/g Remarks: (IUCLID)

1.890 mg/g Remarks: (IUCLID)

1.950 mg/g Remarks: (IUCLID)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material

must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

Incompatibilities

May form explosive mixture with air. Strong oxidizers may cause fire and explosions. Attacks some plastics, rubber and coatings. Able to form peroxides. Incompatible with strong acids; aluminum and its alloys

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Generators of waste containing this contaminant (≧100 kg/mo) must conform with regulations governing storage, transportation, treatment, and waste disposal

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: 1171 IMDG: 1171 IATA: 1171

UN proper shipping name

ADR/RID: ETHYLENE GLYCOL MONOETHYL ETHER IMDG: ETHYLENE GLYCOL MONOETHYL ETHER

IATA: Ethylene glycol monoethyl ether

Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

Packaging group

ADR/RID: III IMDG: III IATA: III

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
EC Inventory:Listed.
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is indicated.The odour warning when the exposure limit value is exceeded is insufficient.Check for peroxides prior to distillation; eliminate if found.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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