Chemical Safety Data Sheet MSDS / SDS
2,6-Dimethylaniline
Revision Date:2026-04-11Revision Number:1
Product identifier
- Product name: 2,6-Dimethylaniline
- CBnumber: CB8327518
- CAS: 87-62-7
- EINECS Number: 201-758-7
- Synonyms: 2,6-dimethylaniline,2,6-Xylidine
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.
Hazard statements
H315 Causes skin irritation
H335 May cause respiratory irritation
H351 Suspected of causing cancer
H411 Toxic to aquatic life with long lasting effects
Substance
- Product name: 2,6-Dimethylaniline
- Synonyms: 2,6-dimethylaniline,2,6-Xylidine
- CAS: 87-62-7
- EC number: 201-758-7
- MF: C8H11N
- MW: 121.18
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaCarbon dioxide (CO2) Foam Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Nitrogen oxides (NOx)
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Nitrogen oxides (NOx)
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
2
1
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact.
Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Storage stability
Recommended storage temperature 2 - 8 °C
Storage class
Storage class (TRGS 510): 6.1A: Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
8.1 Control parameters
Ingredients with workplace control parameters8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 30 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Internet: www.kcl.de).
Full contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 30 min
Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M)
Body Protection
protective clothing
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical statesolid
- b) Colorlight yellow
- c) OdorNo data available
- d) Melting point/freezing pointMelting point: 10 °C
- e) Initial boiling point and boiling range216.6 °C at 1,013.25 hPa - (ECHA)
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsUpper explosion limit: 6.9 %(V)
Lower explosion limit: 1.3 %(V) - h) Flash point91 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pH12.5 at 100 g/l at 20 °C
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: 0.003 Pas at 20 °C 1.7 mPa.s at 50 °C -
OECD Test Guideline 1141.16 mPa.s at 70 °C - OECD Test
Guideline 114 - m) Water solubility7.5 g/L (20 ºC)
- n) Partition coefficient n-octanol/waterlog Pow: 1.96 at 25 °C - - Bioaccumulation is not expected.
- o) Vapor pressure0.2 hPa at 25 °C - OECD Test Guideline 104
- p) Density0.979 g/cm3 at 20 °C - OECD Test Guideline 109
- Relative density0.984 g/mL at 25 °C(lit.)
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- Solubility13g/l
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Violent reactions possible with:
Oxidizing agents acids acid halides halogens
Acid anhydrides rubber various plastics
Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!
Oxidizing agents acids acid halides halogens
Acid anhydrides rubber various plastics
Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!
10.3 Conditions to avoid
Strong heating.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - 840 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Cyanosis
Blood:Changes in spleen.
(RTECS)
Acute toxicity estimate Inhalation - 4 h - 11 mg/l - vapor (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Acute toxicity estimate Dermal - 1,100.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin corrosion/irritation
Remarks: Behavioral:Somnolence (general depressed activity).
Cyanosis
Blood:Changes in spleen.
(RTECS)
Acute toxicity estimate Inhalation - 4 h - 11 mg/l - vapor (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Acute toxicity estimate Dermal - 1,100.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Skin - Rabbit
Result: Irritating to skin. - 4 h (OECD Test Guideline 404)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Serious eye damage/eye irritation
Result: Irritating to skin. - 4 h (OECD Test Guideline 404)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Eyes - Rabbit
Result: Irritating to eyes.
(OECD Test Guideline 405)
Respiratory or skin sensitization
Result: Irritating to eyes.
(OECD Test Guideline 405)
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Result: negative (OECD Test Guideline 429)
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: Positive results were obtained in some in vitro tests.
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: positive
Test Type: in vivo assay
Species: Drosophila melanogaster
Application Route: Oral
Method: OECD Test Guideline 477
Result: negative
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: Positive results were obtained in some in vitro tests.
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: positive
Test Type: in vivo assay
Species: Drosophila melanogaster
Application Route: Oral
Method: OECD Test Guideline 477
Result: negative
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Suspected of causing cancer.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation. - Respiratory system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 12 Days - NOAEL (No observed adverse effect level) - 160 mg/kg - LOAEL (Lowest observed adverse effect level) - 310 mg/kg
Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer., Damage to the eyes., Nausea, Dizziness, Headache, Blood disorders, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
Nausea
Vomiting
Dizziness euphoria
Changes in the blood count
Methaemoglobinaemia with headache, cardiac arrhythmia, drop in blood pressure, dyspnoea, and spasms, key symptom: cyanosis (blue colouration of the blood).
Damage to:
Liver
Kidney
Effect potentiated by: ethanol
Under given conditions, contact with nitrites or nitric acid can lead to the formation of nitrosamines, which have shown themselves to be carcinogenic in animal experiments.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer., Damage to the eyes., Nausea, Dizziness, Headache, Blood disorders, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
Nausea
Vomiting
Dizziness euphoria
Changes in the blood count
Methaemoglobinaemia with headache, cardiac arrhythmia, drop in blood pressure, dyspnoea, and spasms, key symptom: cyanosis (blue colouration of the blood).
Damage to:
Liver
Kidney
Effect potentiated by: ethanol
Under given conditions, contact with nitrites or nitric acid can lead to the formation of nitrosamines, which have shown themselves to be carcinogenic in animal experiments.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
12.1 Toxicity
Toxicity to fish semi-static test LC50 - Oryzias latipes (Orange-red killifish) - > 98 mg/l - 96 h (OECD Test Guideline 203)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 20 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata - > 100 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - ca. 550 mg/l - 0.5 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - 2.23 mg/l - and other aquatic 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 20 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata - > 100 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - ca. 550 mg/l - 0.5 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - 2.23 mg/l - and other aquatic 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
Bioaccumulation Cyprinodontidae - 48 h - 137.5 mg/l(2,6-dimethylaniline)
Bioconcentration factor (BCF): 2.8
Bioconcentration factor (BCF): 2.8
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 1711
IMDG: 1711
IATA-DGR: 1711
IMDG: 1711
IATA-DGR: 1711
14.2 UN proper shipping name
ADR/RID: XYLIDINES, LIQUID
IMDG: XYLIDINES, LIQUID
IATA-DGR: Xylidines, liquid
IMDG: XYLIDINES, LIQUID
IATA-DGR: Xylidines, liquid
14.3 Transport hazard class(es)
ADR/RID: 6.1
IMDG: 6.1
IATA-DGR: 6.1
IMDG: 6.1
IATA-DGR: 6.1
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: yes
IMDG Marine pollutant: yes
IATA-DGR: no
IMDG Marine pollutant: yes
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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