3,3'-Dichlorobenzidine dihydrochloride
Product identifier
- Product name: 3,3'-Dichlorobenzidine dihydrochloride
- CBnumber: CB7345816
- CAS: 612-83-9
- EINECS Number: 210-323-0
- Synonyms: 3,3'-Dichlorobenzidine dihydrochloride,3,3-DICHLOROBENZIDINE DIHYDROCHLORIDE
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 4, Dermal
Skin sensitization, Category 1
Serious eye damage, Category 1
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
Label elements
Pictogram(s)
- Signal wordDanger
H312 Harmful in contact with skin
H317 May cause an allergic skin reaction
H350 May cause cancer
H410 Very toxic to aquatic life with long lasting effects
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P203 Obtain, read and follow all safety instructions before use.
P273 Avoid release to the environment.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P333+P317 If skin irritation or rash occurs: Get medical help.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 3,3'-Dichlorobenzidine dihydrochloride
- Synonyms: 3,3'-Dichlorobenzidine dihydrochloride,3,3-DICHLOROBENZIDINE DIHYDROCHLORIDE
- CAS: 612-83-9
- EC number: 210-323-0
- MF: C12H12Cl4N2
- MW: 326.05
Description of first aid measures
If inhaledMove the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Rinse with pure water for at least 15 minutes. Consult a doctor.
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
SYMPTOMS: This material may cause allergic skin reactions. ACUTE/CHRONIC HAZARDS: This material can be absorbed by inhalation and through the skin. It may also cause allergic skin reactions. When heated to decomposition it emits very toxic fumes. (NTP, 1992)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and ExcretionIn 1954 /results from laboratory tests indicated/ that skin is principal portal of entry of benzidines. ... It was considered likely that the hydrochloride salt could be absorbed percutaneously. Benzidines
Extinguishing media
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Specific Hazards Arising from the Chemical
Flash point data for this compound are not available but it is probably combustible. (NTP, 1992)
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
USE OF SODIUM HYPOCHLORITE BLEACH SOLUTION TO DECONTAMINATE 3,3'-DICHLOROBENZIDINE (DCB) WAS PARTIALLY EFFECTIVE. AN AQUEOUS SOLUTION OF 5% TETRAPOTASSIUM PYROPHOSPHATE AND 10% SODIUM ETHYL HEXYL SULFATE WHEN BLENDED IN A JET SPRAYER EFFECTIVELY REMOVED DCB FROM THE WORK AREA (90-99% REDUCTION). ONCE REMOVED FROM THE WORKSITE AND COLLECTED IN A CENTRAL LOCATION, IT WAS THEN DETERMINED THAT THE DIAZOTIZATION REACTION (THE ADDITION OF SO4, ICE AND NaNO3) OCCURRED TO ELIMINATE ANY DETECTABLE DCB FROM THE WASHINGS. 3,3'-DICHLOROBENZIDINE
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store in cool, dry place. Protection from light and air is recommended for long term storage. Chemical Carcinogens
Control parameters
Occupational Exposure limit values| Component | 3,3'-dichlorobenzidine dihydrochloride |
|---|---|
| CAS No. | 612-83-9 |
|
NIOSH considers 3,3'-dichlorobenzidine to be a potential occupational carcinogen. /3,3'-Dichlorobenzidine (and its salts)/ NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /3,3'-Dichlorobenzidine (and its salts)/ |
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
no data available
Information on basic physicochemical properties
- Physical stateneat
- Colour
White crystals; white to light-gray powder
- Odour
mild odor
- Melting point/freezing point
132-137°C
- Boiling point or initial boiling point and boiling range
385°C at 760 mmHg
- Flammability
no data available
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
no data available
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility
less than 1 mg/mL at 70.7° F (NTP, 1992)
- Partition coefficient n-octanol/water
no data available
- Vapour pressure
no data available
- Density and/or relative density
no data available
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
NIOSH considers 3,3'-dichlorobenzidine to be a potential occupational carcinogen. 3,3'-Dichlorobenzidine (and its salts)
Chemical stability
no data available
Possibility of hazardous reactions
3,3'-DICHLOROBENZIDINE DIHYDROCHLORIDE reacts as a weak acid. May react vigorously with strong oxidizing agents. May generate flammable gases with strong reducing agents.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomp it emits very toxic fumes of hydrogen chloride & nitrogen oxides.
Acute toxicity
- Oral: LD50 Rat (Sprague-Dawley) oral 3.82 g/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Based on statistically significantly increased tumor incidence in rats, mice and dogs. Additional support is provided by positive evidence of genotoxicity and structural relationship to the known human bladder carcinogen benzidine. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Sufficient. 3,3'-Dichlorobenzidine
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN3077 (For reference only, please check.)
IMDG: UN3077 (For reference only, please check.)
IATA: UN3077 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 9 (For reference only, please check.)
IMDG: 9 (For reference only, please check.)
IATA: 9 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.