11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - female - 300 - 2,000 mg/kg (EC Directive 96/54/EC B.1tris)
Inhalation: No data available
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (Regulation (EC) No. 440/2008, Annex, B.3)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Bovine cornea
Result: No eye irritation - 10 min (OECD Test Guideline 437)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: positive (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: In vitro mammalian cell gene mutation test
Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: Regulation (EC) No. 440/2008, Annex, B.13/14 (Ames test)
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging the unborn child.
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Oral - May cause damage to organs through prolonged or repeated exposure.
- Blood
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 90 Days - NOAEL (No observed adverse effect level) - 10 mg/kg - LOAEL (Lowest observed adverse effect level) - > 1,000 mg/kg