105454-04-4 - Safety Data Sheet

Chemical Safety Data Sheet MSDS / SDS

Revision Date:2026-03-20Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

CBnumber: CB11468941
CAS: 105454-04-4

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Signal wordDanger

Precautionary statements

P264 Wash skin thouroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321 Specific treatment (see … on this label).

P330 Rinse mouth.

P405 Store locked up.

P501 Dispose of contents/container to..…

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P281 Use personal protective equipment as required.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P405 Store locked up.

P501 Dispose of contents/container to..…

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash skin thouroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P314 Get medical advice/attention if you feel unwell.

P501 Dispose of contents/container to..…

Hazard statements

H360 May damage fertility or the unborn child

H372 Causes damage to organs through prolonged or repeated exposure

H351 Suspected of causing cancer

H340 May cause genetic defects

H301 Toxic if swalloed

SECTION 3: Composition/information on ingredients

Substance

Product name: 7-Epitaxol
Synonyms: Epitaxol;EPITAXOL, 7-
CAS: 105454-04-4
MF: C47H51NO14
MW: 853.91

SECTION 4: First aid measures

Description of first aid measures

General information

Immediately remove any clothing soiled by the product.
Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident.
In case of irregular breathing or respiratory arrest provide artificial respiration.

After inhalation

In case of unconsciousness place patient stably in side position for transportation.

After skin contact

Immediately wash with water and soap and rinse thoroughly.

After eye contact

Rinse opened eye for several minutes under running water. Then consult a doctor.

After swallowing

Do not induce vomiting; immediately call for medical help.

Information for doctor

Most important symptoms and effects, both acute and delayed

No further relevant information available.

Indication of any immediate medical attention and special treatment needed

No further relevant information available.

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing agents

Use fire fighting measures that suit the environment.
A solid water stream may be inefficient.

Special hazards arising from the substance or mixture

No further relevant information available.

Advice for firefighters

Protective equipment

No special measures required.

NFPA 704

HEALTH	2	Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE	0	Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Not required.

Environmental precautions

Do not allow to enter sewers/ surface or ground water.

Methods and material for containment and cleaning up

Dispose contaminated material as waste according to section 13.
Ensure adequate ventilation.

Protective Action Criteria for Chemicals

PAC-1

Substance is not listed.

PAC-2

Substance is not listed.

PAC-3

Substance is not listed.

Reference to other sections

See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

SECTION 7: Handling and storage

Handling

Precautions for safe handling

Thorough dedusting.

Information about protection against explosions and fires

No special measures required.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed.
Store in accordance with information listed on the product insert.

Storage

Store in accordance with information listed on the product insert.

Requirements to be met by storerooms and receptacles

No special requirements.

Information about storage in one common storage facility

Not required.

Further information about storage conditions

None.

Specific end use(s)

No further relevant information available.

SECTION 8: Exposure controls/personal protection

Additional information about design of technical systems

No further data; see section 7.

Control parameters

Components with limit values that require monitoring at the workplace

Not required.

Additional information

The lists that were valid during the creation were used as basis.

Exposure controls

Personal protective equipment

General protective and hygienic measures

Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Store protective clothing separately.

Breathing equipment

In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.

Protection of hands

Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation

Material of gloves

The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.

Penetration time of glove material

The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.

Eye protection

Tightly sealed goggles

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Physical StateSolid
ColorWhite to off-white
OdorCharacteristic
Structural FormulaC47H51NO14
Molecular Weight853.9 g/mol
Odor ThresholdNot determined.
pHNot applicable.
Melting point/Melting rangeUndetermined.
Boiling point/Boiling range957.1±65.0 °C(Predicted)
Flash pointNot applicable.
Flammability (solid,gas)Product is not flammable.
Decomposition temperatureNot determined.
Ignition temperatureNot determined.
Danger of explosionProduct does not present an explosion hazard.
Explosion limitsLower: Not determined.
Upper: Not determined.
Vapor PressureNot applicable.
Density1.39±0.1 g/cm3 (20 ºC 760 Torr)
Relative Density1.39±0.1 g/cm3 (20 ºC 760 Torr)
Vapor DensityNot applicable.
Evaporation RateNot applicable.
Solubility in / Miscibility withDMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
WaterNot determined.
Partition coefficient (n-octanol/water)Not determined.
DynamicNot applicable.
KinematicNot applicable.
SOLUBILITYDMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO 10 mg/ml; Ethanol: 5 mg/ml
Other informationNo information available

SECTION 10: Stability and reactivity

Reactivity

No further relevant information available.

Chemical stability

Thermal decomposition / conditions to be avoided

No decomposition if used according to specifications.

Possibility of hazardous reactions

No dangerous reactions known.

Conditions to avoid

No further relevant information available.

Incompatible materials

strong oxidizing agents, strong reducing agents

Hazardous decomposition products

carbon oxides, nitrogen oxides

SECTION 11: Toxicological information

Information on toxicological effects

Primary irritant effect

on the skin

No irritant effect.

on the eye

No irritating effect.

Sensitization

No sensitizing effects known.

Additional toxicological information

Carcinogenic categories

IARC (International Agency for Research on Cancer)

Substance is not listed.

NTP (National Toxicology Program)

Substance is not listed.

OSHA-Ca (Occupational Safety & Health Administration)

Substance is not listed.

SECTION 12: Ecological information

Toxicity

Aquatic toxicity

No further relevant information available.

Persistence and degradability

No further relevant information available.

Behavior in environmental systems

Bioaccumulative potential

No further relevant information available.

Mobility in soil

No further relevant information available.

Additional ecological information

General notes

Water hazard class 3 (Self-assessment) extremely hazardous for water
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.

Results of PBT and vPvB assessment

PBT

Not applicable.

vPvB

Not applicable.

PBT:

Not applicable.

vPvB:

Not applicable.

Other adverse effects

No further relevant information available.

SECTION 13: Disposal considerations

Waste treatment methods

Recommendation

Must not be disposed of together with household garbage. Do not allow product to reach sewage system.

Uncleaned packagings

Recommendation

Disposal must be made according to official regulations.

SECTION 14: Transport information

UN-Number

DOT, IMDG, IATA UN2811

UN proper shipping name

DOT Toxic solids, organic, n.o.s. (7-epi Paclitaxel)
IMDG TOXIC SOLID, ORGANIC, N.O.S. (7-epi Paclitaxel)
IATA Toxic solid, organic, n.o.s. (7-epi Paclitaxel)

Transport hazard class(es)

DOT

Class: 6.1 Toxic substances
Label: 6.1

IMDG, IATA

Class: 6.1 Toxic substances
Label: 6.1

Packing group

DOT, IMDG, IATA III

Environmental hazards

Not applicable.

Special precautions for user

Warning: Toxic substances

Hazard identification number (Kemler code)

EMS Number

F-A,S-A

Stowage Category

Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code

Not applicable.

Transport/Additional information

DOT:

Quantity limitations

On passenger aircraft/rail: 100 kg
On cargo aircraft only: 200 kg

IMDG:

Limited quantities (LQ)

5 kg

Excepted quantities (EQ)

Code: E1
Maximum net quantity per inner packaging: 30 g
Maximum net quantity per outer packaging: 1000 g

IATA:

Remarks

When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of
E1, E2, E4, or E5, this item meets the De Minimis
Quantities exemption, per IATA 2.6.10.
Therefore packaging does not have to be labeled as
Dangerous Goods/Excepted Quantity.

UN "Model Regulation"

UN 2811 TOXIC SOLID, ORGANIC, N.O.S. (7-EPI
PACLITAXEL), 6.1, III

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

No further relevant information available.

Sara

Section 355 (extremely hazardous substances):	Substance is not listed.
Section 313 (Specific toxic chemical listings):	Substance is not listed.
TSCA (Toxic Substances Control Act):	Substance is not listed.
Hazardous Air Pollutants:	Substance is not listed.

Proposition 65

Chemicals known to cause cancer:	Substance is not listed.
Chemicals known to cause reproductive toxicity for females:	Substance is not listed.
Chemicals known to cause reproductive toxicity for males:	Substance is not listed.
Chemicals known to cause developmental toxicity:	Substance is not listed.

Chemicals known to cause cancer

Substance is not listed.

Chemicals known to cause reproductive toxicity for females

Substance is not listed.

Chemicals known to cause reproductive toxicity for males

Substance is not listed.

Chemicals known to cause developmental toxicity

Substance is not listed.

Carcinogenic categories

EPA (Environmental Protection Agency):

Substance is not listed.

TLV (Threshold Limit Value)

Substance is not listed.

NIOSH-Ca (National Institute for Occupational Safety and Health)

Substance is not listed.

Chemical safety assessment

A Chemical Safety Assessment has not been carried out.

SECTION 16: Other information

Abbreviations and acronyms

IMDG: International Maritime Code for Dangerous Goods
DOT: US Department of Transportation
IATA: International Air Transport Association
EINECS: European Inventory of Existing Commercial Chemical Substances
CAS: Chemical Abstracts Service (division of the American Chemical Society)
NFPA: National Fire Protection Association (USA)
HMIS: Hazardous Materials Identification System (USA)
PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative
NIOSH: National Institute for Occupational Safety
OSHA: Occupational Safety & Health
TLV: Threshold Limit Value
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
Acute Toxicity - Oral 3: Acute toxicity – Category 3
Germ Cell Mutagenicity 1B: Germ cell mutagenicity – Category 1B
Carcinogenicity 2: Carcinogenicity – Category 2
Toxic to Reproduction 1B: Reproductive toxicity – Category 1B
Specific Target Organ Toxicity - Repeated Exposure 1: Specific target organ toxicity (repeated exposure) – Category 1

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.