NITROFEN

Acute toxicity - Category 4, Oral

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 1B

H302 Harmful if swallowed

H350 May cause cancer

H360 May damage fertility or the unborn child

H400 Very toxic to aquatic life

H410 Very toxic to aquatic life with long lasting effects

P201 Obtain special instructions before use.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P405 Store locked up.

P501 Dispose of contents/container to..…

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P203 Obtain, read and follow all safety instructions before use.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P273 Avoid release to the environment.

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Rest. Refer for medical attention .

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin and eyes. ACUTE/CHRONIC HAZARDS: This compound is toxic by ingestion. It may cause irritation of the skin and eyes. When heated to decomposition it emits toxic fumes of nitrogen oxides and chlorine. (NTP, 1992)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aromatic hydrocarbons and related compounds

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Use water spray, powder, foam, carbon dioxide.

Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P3 filter respirator for toxic particles.

Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P3 filter respirator for toxic particles.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from food and feedstuffs. Well closed.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

no data available

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety spectacles or eye protection in combination with breathing protection if powder.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

On combustion, forms toxic fumes.

Darkens under exposure to light

FLAMMABLEDust explosion possible if in powder or granular form, mixed with air.NITROFEN is a nitrated and halogenated ether derivative.

no data available

no data available

When heated to decomp it emits very toxic fumes of hydrogen chloride and nitrogen oxides.

no data available

no data available

no data available

no data available

No data are available in humans. Sufficient evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 2B: The agent is possibly carcinogenic to humans.

no data available

The substance is irritating to the skin and respiratory tract. The substance may cause effects on the central nervous system.

Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes malformations in human babies.

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.

Nitrofen degraded slowly under aerobic and anaerobic conditions with a sewage inoculum, but only in the presence of an external source of carbon and energy; after 88 days of incubation 6% and 4% degradation occurred under aerobic and anaerobic conditions, respectively(1). Four unspecified products were formed in the aerobic experiment, all more hydrophilic than the parent compound(1). The corresponding amine was identified as a biodegradation product of nitrofen(2). Nitrofen, present at 100 mg/L, reached 2% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3). Nitrofen was degraded slowly by soil microorganisms during the first week and persisted more than 4 weeks when it was the sole source of carbon(4). When other sources of carbon were added, degradation occurred in 3 weeks(4). After 16 weeks of incubation in laboratory experiments, 15 and 38% of the initial concentration (10 ppm) of nitrofen remained in sandy loam (0.7% organic matter, pH 7.0) and muck (36.7% organic matter, pH 7.0) soils, respectively, 94% and 82% nitrofen remained in the same soils that were sterilized(5). Nitrofen slowly but completely biodegraded to carbon dioxide in typical soils likely proceeding through diphenyl ether cleavage(6). In a river die-away test using Asahi River (Japan) water, 1% of the nitrofen remained after 50 days incubation at 20 deg C(7).

The BCF of nitrofen in orange-red killifish (Oryzias latipes), exposed for 10 weeks to 50 and 5.0 ug/L was 2900-5370 and 2720-4220, respectively(1). Nitrofen bioconcentrated in algae, snails, mosquito larvae, and fish in a 3-day model aquatic ecosystem; <20% of the herbicide was found as metabolites(2). A 33-day model terrestrial-aquatic ecosystem in which 1.29 kg/ha of nitrofen was injected into paddy sand containing rice seedlings(2). The BCFs for fish, mosquito larvae, snails, and algae in this experiment were 1550, 3190, 2770, and 405, respectively(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC), provided the compound is not metabolized by the organism(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of nitrofen can be estimated to be 7,800(SRC). According to a classification scheme(2), this estimated Koc value suggests that nitrofen is expected to be immobile in soil(SRC). Results of soil thin layer chromatography tests showed that nitrofen is immobile in soil(3). Similarly results were obtained in column leaching studies with both Plainfield sand and muck soils and indicate that leaching of nitrofen from arable soils will be negligible(4). In field experiments in sandy loam, heavy clay, and silty clay soils, <5% of the applied nitrofen was recovered from the 5-10 cm soil level, indicating that minimal leaching had occurred(5).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).Carrier solvents used in commercial formulations may change physical and toxicological properties.Do NOT take working clothes home.