Chemical Safety Data Sheet MSDS / SDS

Acrylonitrile

Revision Date:2023-12-02Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Acrylonitrile
CBnumber: CB8764818
CAS: 107-13-1
EINECS Number: 203-466-5
Synonyms: acrylonitrile,2-Propenenitrile

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P311 Call a POISON CENTER or doctor/physician.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P201 Obtain special instructions before use.

Hazard statements

H411 Toxic to aquatic life with long lasting effects

H370 Causes damage to organs

H361 Suspected of damaging fertility or the unborn child

H350 May cause cancer

H335 May cause respiratory irritation

H331 Toxic if inhaled

H318 Causes serious eye damage

H317 May cause an allergic skin reaction

H315 Causes skin irritation

H311 Toxic in contact with skin

H301 Toxic if swalloed

H225 Highly Flammable liquid and vapour

Disposal

WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/acrylonitrile

SECTION 3: Composition/information on ingredients

Substance

Product name: Acrylonitrile
Synonyms: acrylonitrile,2-Propenenitrile
CAS: 107-13-1
EC number: 203-466-5
MF: C3H3N
MW: 53.06

SECTION 4: First aid measures

Description of first aid measures

General advice

First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Carbon dioxide (CO2) Foam Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx) Combustible.

Pay attention to flashback.

Vapors are heavier than air and may spread along floors.

Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	4	Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid)
FIRE	3	Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT	2	Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and

sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.

Light sensitive.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: butyl-rubber

Minimum layer thickness: 0,3 mm Break through time: 480 min

Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)

Splash contact Material: Chloroprene

Minimum layer thickness: 0,6 mm Break through time: 37 min

Material tested:Camapren? (KCL 722 / Aldrich Z677493, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter A-(P3)

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

Exposure limits

NIOSH REL: TWA 1 ppm, 15-min C 1 ppm, IDLH 85 ppm; OSHA PEL: TWA 2 ppm, 15-min C 10 ppm; ACGIH TLV: TWA 2 ppm.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolorless clear, liquid
Odourpungent
Odour Threshold21,4 ppm
pH6.0-7.5 (50g/l, H2O, 20℃)
Melting point/freezing pointMelting point/range: -83 °C - lit.
Initial boiling point and boiling range77 °C - lit.
Flash point-5 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limits Upper explosion limit: 28 %(V) Lower explosion limit: 2 %(V)
Vapour pressure 133,3 hPa at 23,6 °C
Vapour density 1,83 - (Air = 1.0)
Relative density0,806 g/cm3 No data available
Water solubilitysoluble
Partition coefficient: n-octanol/waterlog Pow: 0,016 at 21 °C - Bioaccumulation is not expected.
Autoignition temperature481 °C at 1.013 hPa
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 0,34 mPa.s at 25 °C
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant1.30 at 30.00 °C (headspace-GC, Hovorka et al., 2002)

Other safety information

Surface tension 27,3 mN/m at 24 °C

Relative vapor density

1,83 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Vapors may form explosive mixture with air.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Risk of explosion with:

Bromine

Sodium hydroxide Esters

Chlorine Nitric acid

Violent polymerization may be caused by: alkali hydroxides

Strong bases Oxidizing agents Copper

Copper alloys sulfuric acid silver salt

polymerisation initiators Peroxides

sodium amide with

Sodium hydroxide Exothermic reaction with: chlorosulfonic acid

Strong acids

Conditions to avoid

Heat. May polymerize on exposure to light. Warming.

Incompatible materials

No data available

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

Acute toxicity estimate Oral - 95,1 mg/kg
(Calculation method)
LD50 Oral - Rat - female - 95,1 mg/kg Remarks: (ECHA)
Acute toxicity estimate Inhalation - 4 h - 2,05 mg/l (Calculation method)
LC50 Inhalation - Rat - female - 4 h - 2,05 mg/l (OECD Test Guideline 403)
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Acute toxicity estimate Dermal - 250 mg/kg (Calculation method)
LD50 Dermal - Rabbit - 250 mg/kg Remarks: (IUCLID)

Skin corrosion/irritation

Skin - Rabbit
Result: Skin irritation - 24 h (OECD Test Guideline 404)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Risk of serious damage to eyes. (OECD Test Guideline 405)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Respiratory or skin sensitization

(OECD Test Guideline 406)

Germ cell mutagenicity

Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: Metabolic activation Method: OECD Test Guideline 471 Result: positive
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation Result: positive
Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test Test system: mouse lymphoma cells
Metabolic activation: without metabolic activation Method: OECD Test Guideline 476
Result: positive

Carcinogenicity

No data available

Reproductive toxicity

Suspected of damaging fertility. Suspected of damaging the unborn child.

Specific target organ toxicity - single exposure

May cause respiratory irritation.
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Toxicity

LD50 orally in rats: 0.093 g/kg (Smyth, Carpenter)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

semi-static test LC50 - Oryzias latipes - 5,1 mg/l - 96 h (OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - 2,5 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae

static test ErC50 - Pseudokirchneriella subcapitata - 10 mg/l - 72 h (OECD Test Guideline 201)

Toxicity to bacteria

EC5 - Pseudomonas putida - 53 mg/l - 16 h

Remarks: (Lit.)

(maximum permissible toxic concentration)

Persistence and degradability

Biodegradability aerobic - Exposure time 14 d

Result: 100 % - Inherently biodegradable. (OECD Test Guideline 302C)

Ratio BOD/ThBOD 70 %

Remarks: (Lit.)

Bioaccumulative potential

Bioaccumulation Lepomis macrochirus - 14 d

- 9,94 μg/l(acrylonitrile)

Bioconcentration factor (BCF): 48

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Incompatibilities

May form explosive mixture with air. Reacts violently with strong acids; strong alkalis; bromine, and tetrahydrocarbazole. It may also polymerize on contact with oxygen, heat, strong light, peroxides, and concentrated or heated alkalis. Reacts with oxidizers, acids, bromine, amines.

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Waste Disposal

Incineration with provision for nitrogen oxides removal from effluent gases by scrubbers or afterburners. A chemical disposal method has also been suggested involving treatment with alcoholic NaOH; the alcohol is evaporatedand calcium hypochlorite added; after 24 hours the product is flushed to the sewer with large volumes of water.

SECTION 14: Transport information

UN number

ADR/RID: 1093 IMDG: 1093 IATA: 1093

14.2

UN proper shipping name

ADR/RID: ACRYLONITRILE, STABILIZED IMDG: ACRYLONITRILE, STABILIZED

IATA: Acrylonitrile, stabilized

Passenger Aircraft: Not permitted for transport

14.3

Transport hazard class(es)

ADR/RID: 3 (6.1) IMDG: 3 (6.1)

IATA: 3 (6.1)

14.4

Packaging group

ADR/RID: I IMDG: I

IATA: I

14.5

Environmental hazards

ADR/RID: yes IMDG Marine pollutant: yes

IATA: no

14.6

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

EC Inventory:Listed.

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.Exposure to the substance will result in cyanide formation.See ICSC 0671.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.The odour warning when the exposure limit value is exceeded is insufficient.Rinse contaminated clothing with plenty of water because of fire hazard.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.