ChemicalBook
Chemical Safety Data Sheet MSDS / SDS

Calicheamicin

Revision Date:2026-04-25Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Calicheamicin
  • CBnumber: CB01353750
  • CAS: 108212-75-5
  • Synonyms: calicheamicin,Calicheamicin gamma1

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P314 Get medical advice/attention if you feel unwell.
P501 Dispose of contents/container to..…
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…
Hazard statements
H341 Suspected of causing genetic defects
H372 Causes damage to organs through prolonged or repeated exposure
H361 Suspected of damaging fertility or the unborn child
H302 Harmful if swallowed

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Calicheamicin
  • Synonyms: calicheamicin,Calicheamicin gamma1
  • CAS: 108212-75-5
  • MF: C55H74IN3O21S4
  • MW: 1368.34

SECTION 4: First aid measures

4.1 Description of first aid measures

Eye contact
Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.
Skin contact
Rinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.
Inhalation
Immediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth- to-mouth resuscitation.
Ingestion
Wash out mouth with water; Do NOT induce vomiting; call a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2).

4.3 Indication of any immediate medical attention and special treatment needed

Treat symptomatically.

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media
Use water spray, dry chemical, foam, and carbon dioxide fire extinguisher.

5.2 Special hazards arising from the substance or mixture

During combustion, may emit irritant fumes.

5.3 Advice for firefighters

Wear self-contained breathing apparatus and protective clothing.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
Refer to protective measures listed in sections 8.

6.2 Environmental precautions

Try to prevent further leakage or spillage. Keep the product away from drains or water courses.

6.3 Methods and materials for containment and cleaning up

Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.

7.2 Conditions for safe storage, including any incompatibilities

Keep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.
Recommended storage temperature
Powder -20°C 3 years 4°C 2 years
In solvent -80°C 6 months -20°C 1 month
Shipping at room temperature if less than 2 weeks.

7.3 Specific end use(s)

No data available.

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Components with workplace control parameters
This product contains no substances with occupational exposure limit values.

8.2 Exposure controls

Engineering controls
Ensure adequate ventilation. Provide accessible safety shower and eye wash station.
Personal protective equipment
Eye protection
Safety goggles with side-shields.
Hand protection
Protective gloves.
Skin and body protection
Impervious clothing.
Respiratory protection
Suitable respirator.
Environmental exposure controls
Keep the product away from drains, water courses or the soil. Clean spillages in a safe way as soon as possible.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • AppearanceSolid
  • OdorNo data available
  • Odor thresholdNo data available
  • pHNo data available
  • Melting/freezing pointNo data available
  • Boiling point/rangeNo data available
  • Flash pointNo data available
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limitsNo data available
  • Vapor pressureNo data available
  • Vapor densityNo data available
  • Relative density1.57g/cm3
  • Water SolubilityNo data available
  • Partition coefficientNo data available
  • Auto-ignition temperatureNo data available
  • Decomposition temperatureNo data available
  • ViscosityNo data available
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available
  • SolubilityDMSO : ≥ 100 mg/mL (73.08 mM);Water : < 0.1 mg/mL (insoluble)
  • Physical stateSolid
  • ColourWhite to yellow

9.2 Other safety information

No data available.

SECTION 10: Stability and reactivity

10.1 Reactivity

No data available.

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

No data available.

10.4 Conditions to avoid

No data available.

10.5 Incompatible materials

Strong acids/alkalis, strong oxidising/reducing agents.

10.6 Hazardous decomposition products

Under fire conditions, may decompose and emit toxic fumes.
Other decomposition products - no data available.

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity
Classified based on available data. For more details, see section 2
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
IARC
No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
ACGIH
No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.
NTP
No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.
OSHA
No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Additional information
This information is based on our current knowledge. However the chemical, physical, and toxicological properties have not been completely investigated.

SECTION 12: Ecological information

12.1 Toxicity

No data available.

12.2 Persistence and degradability

No data available.

12.3 Bioaccumlative potential

No data available.

12.4 Mobility in soil

No data available.

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.

12.6 Other adverse effects

No data available.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product
Dispose substance in accordance with prevailing country, federal, state and local regulations.
Contaminated packaging
Conduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.

SECTION 14: Transport information

DOT (US)

Proper shipping name
TOXIC SOLID,ORGANIC, N. O. S.
UN number
2811
Class
6.1
Packing group
Ⅰ

IMDG

Proper shipping name
TOXIC SOLID,ORGANIC, N. O. S.
UN number
2811
Class
6.1
Packing group
Ⅰ

IATA

Proper shipping name
TOXIC SOLID,ORGANIC, N. O. S.
UN number
2811
Class
6.1
Packing group
Ⅰ

SECTION 15: Regulatory information

SARA 302 Components

No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.

SARA 313 Components

This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

SARA 311/312 Hazards

No SARA Hazards.

Massachusetts Right To Know Components

No components are subject to the Massachusetts Right to Know Act.

Pennsylvania Right To Know Components

No components are subject to the Pennsylvania Right to Know Act.

New Jersey Right To Know Components

No components are subject to the New Jersey Right to Know Act.

California Prop. 65 Components

This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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