Chlorothalonil

Serious eye damage, Category 1

Skin sensitization, Category 1

Acute toxicity - Category 2, Inhalation

Specific target organ toxicity – single exposure, Category 3

Carcinogenicity, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H225 Highly Flammable liquid and vapour

H302 Harmful if swallowed

H312 Harmful in contact with skin

H317 May cause an allergic skin reaction

H318 Causes serious eye damage

H319 Causes serious eye irritation

H330 Fatal if inhaled

H332 Harmful if inhaled

H335 May cause respiratory irritation

H351 Suspected of causing cancer

H410 Very toxic to aquatic life with long lasting effects

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P284 Wear respiratory protection.

P310 Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P317 Get medical help.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P316 Get emergency medical help immediately.

P320 Specific treatment is urgent (see ... on this label).

P319 Get medical help if you feel unwell.

P318 IF exposed or concerned, get medical advice.

P391 Collect spillage.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Refer for medical attention .

SYMPTOMS: Symptoms of exposure to this compound include dermatitis and gastrointestinal, skin and upper respiratory tract irritation. ACUTE/CHRONIC HAZARDS: This compound is a positive animal carcinogen. When heated to decomposition it emits toxic fumes of chloride ion, NOx and cyanide ion. (NTP, 1992)

1. Wash off dermal contamination with soap and water. Remove contamination of the eyes by flushing with copious amounts of water. If irritation persists, specialized medical care should be obtained. Substituted benzenes

Fire Extinguishing Media: CO2, foam, dry chemical or water.

Literature sources indicate that this compound is nonflammable. (NTP, 1992)

Use water spray, foam, powder, carbon dioxide.

Personal protection: chemical protection suit and protective gloves. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: chemical protection suit and protective gloves. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Solid spillage should be picked up with an industrial vacuum cleaner and disposed of in accordance with local regulations.

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access.Keep in cool, dry, ventilated place.

MAK sensitization of skin (SH)

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety spectacles or eye protection in combination with breathing protection if powder.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

Decomposes on heating. This produces toxic and corrosive fumes including hydrogen chloride (see ICSC 0163) and nitrogen oxides.

Thermally stable at ambient temperatures. Stable to u.v. light in aqueous media and in crystalline state. Stable in acidic and moderately alkaline aqueous solutions; slow hydrolysis at pH >9.

Chlorothalonil is non-flammable and non-explosive.CHLOROTHALONIL is stable in neutral or acidic aqueous media. May react violently with strong oxidizing acids [Farm Chemicals Handbook]. Incompatible with other oxidizing agents such as peroxides and epoxides. Breaks down slowly in basic aqueous media (half-life 38.1 days at pH 9). [Farm Chemicals Handbook].

no data available

Cyanides

May decompose at high temp to emit hydrogen chloride.

no data available

no data available

no data available

no data available

Cancer Classification: Group B2 Probable Human Carcinogen

no data available

The substance is severely irritating to the eyes. The substance is irritating to the respiratory tract. The substance is mildly irritating to the skin.

Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization.

A harmful concentration of airborne particles can be reached quickly when dispersed.

AEROBIC: In an aerobic grab sample study, 60.5% chlorothalonil (initial concentration of 38 ppm) remained in an alluvial silty loam (25 deg C and pH 6.4) after 7 days(1). At an initial concentration of 40 ppm, 67.5% (20 deg C) and 45.0% (25 deg C) chlorothalonil remained after 7 days in an alluvial silty loam (pH 6.4) held at a 60% moisture capacity(1). In the same soil held at moisture capacities of 100, 60, 40, and 20%, the amount of chlorothalonil (initial concentration of 40 ppm) remaining was determined to be 85, 22, 45, and 65%, respectively, after 7 days. Chlorothalonil biodegraded mainly through dechlorination and partly by substitution reaction yielding the biodegradation products: isophthalonitrile, mono-, di- and tri-chlorinated isophthalonitriles, 2,5,6-trichloro-4-hydroxyisophthalonitrile and 2,5,6-trichloro-4-methoxyisophthalonitrile(1). Aerobic biodegradation half-lives of chlorothalonil in four different soils were reported as 10, 10, 15 and 40 days(2). After 60 days the metabolite 2,5,6-trichloro-4-hydroxyisophtalonitrile was present at up to 32% of the initially applied amount; the metabolite 3-cyano-2,4,5,6-tetrachlorobenzamide was present at up to about 7% at both days 7 and 16 of the study. Aerobic aquatic half-lives of chlorothalonil typically range from 2 to 200 hours(2). Other reported metabolites are 1,3-dicarbamoyl-2,4,5,6-tetrachlorobenzene, 1-carbamoyl-3-cyano-4-hydroxy-2,5,6-trichlorobenzene, 2,4,6-trichloro-4-(methylthio)isophthalonitrile and pentachloronitrobenzene(3).

Bioconcentration factors of 75 (edible) and 264 (whole body) were measured for chlorothalonil in bluegill sunfish(1). BCF values of 9.4 (edible) and 16 (whole body) were reported for catfish(1). Carp exposed to 3 ug/L chlorothalonil over a 6 week incubation period had reported maximum BCF values of 125 (2). A BCF of 264 was determined in bluegill (Lepomis macrochirus) exposed for 28 days(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms can be low to high(SRC). Chlorothalonil BAFs wet weight and lipid based in zooplankton from three lakes in southern Ontario, Canada were 14-1500 and 140-190,000, respectively; samples were collected in 2003 and 2004(5).

A Koc value of 1800 has been determined based on adsorption isotherms of chlorothalonil on 3 black soils and 1 clay mineral, Na-bentonite soil(1). Other reported Koc values are 1300 to 14,000(2). Laboratory batch equilibrium studies with four soils showed chlorothalonil to possess limited mobility in silty clay loam, silt, sandy loam, and sand with calculated Koc values were 1400, 7000, 1100, and 900, respectively(3). According to a classification scheme(4), these Koc values suggest the mobility of chlorothalonil in soils will be low to immobile(SRC). The Koc of sediment from recycling ponds was 2270 to 2450(5).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3439 (For reference only, please check.)

IMDG: UN3439 (For reference only, please check.)

IATA: UN3439 (For reference only, please check.)

ADR/RID: NITRILES, SOLID, TOXIC, N.O.S. (For reference only, please check.)

IMDG: NITRILES, SOLID, TOXIC, N.O.S. (For reference only, please check.)

IATA: NITRILES, SOLID, TOXIC, N.O.S. (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Carrier solvents used in commercial formulations may change physical and toxicological properties.