DINITROTOLUENE

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 2

H301 Toxic if swallowed

H311 Toxic in contact with skin

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H350 May cause cancer

H373 May cause damage to organs through prolonged or repeated exposure

H410 Very toxic to aquatic life with long lasting effects

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P316 Get emergency medical help immediately.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P318 IF exposed or concerned, get medical advice.

P319 Get medical help if you feel unwell.

P391 Collect spillage.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

no data available

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Ingestion or overexposure to vapors from hot liquid can cause loss of color, nausea, headache, dizziness, drowsiness, collapse. Hot liquid can burn eyes and skin. Prolonged skin contact with solid can give same symptoms as after inhalation or ingestion. (USCG, 1999)

In case of ingestion, induction of emesis is not recommended because of the potential for central nervous system depression. Gastric lavage and administration of activated charcoal may be considered soon after ingestion, provided airways are protected. Dinitrotoluene

Water, dry chemical, or carbon dioxide from protected location.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

Special Hazards of Combustion Products: Nitrogen oxides and dense black smoke are produced in a fire. Behavior in Fire: Decomposition is self- sustaining at 280°C. Containers may explode in a fire. (USCG, 1999)

Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

1) remove all ignition sources. 2) ventilate area of spill. 3) for small quantities, sweep onto paper or other suitable material & burn in suitable combustion chamber which allows burning in unconfined condition & is equipped with appropriate effluent gas cleaning device. large quantities may be reclaimed; ... if ... not practical, dissolve in fuel oil & atomize in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Fireproof. Separated from strong bases, food and feedstuffs, oxidants and strong reducing agents. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens

TLV: 0.2 mg/m3, as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued.MAK: skin absorption (H); carcinogen category: 2

no data available

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear safety goggles.

Protective gloves. Protective clothing.

Use local exhaust or breathing protection.

no data available

NIOSH considers dinitrotoluene to be a potential occupational carcinogen. [50 mg/cu m] Dinitrotoluene

Heating may cause violent combustion or explosion. Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides even in the absence of air. Reacts with reducing agents, strong bases and oxidants. This generates fire and explosion hazard.

May explode on heating. Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides even in the absence of air. Reacts with reducing agents, strong bases and oxidants. This generates explosion hazard.

no data available

Dust explosion possible if in powder or granular form, mixed with air.,Dust explosion possible if in powder or granular form, mixed with air.DINITROTOLUENE is incompatible with strong oxidizing agents, caustics, active metals, tin and zinc (NTP, 1992). Decomposes at 250°C. Prolonged heating below this temperature causes some decomposition, and the presence of impurities may decrease the decomposition temperatures. Decomposition is self-sustaining at 280°C. Containers may explode in a fire (USCG, 1999). Reacts with oxidizing agents, caustics, nitric acid, reducing materials and metals such as zinc or tin. May react violently in the presence of a base or when heated to the boiling point. Attacks some forms of plastics, rubbers and coatings. (NTP, 1992).

no data available

Dinitrotoluene held at 210 deg C (rather than 125 deg C as intended) for 10 days in a 50 mm steam heated transfer pipeline exploded. Subsequent tests showed decomposition at 210 deg C (producing a significant pressure rise) in 1 day, and presence of sodium carbonate (but not rust) reduced the induction period. A maximum handling temperature of 150 deg C was recommended, (when the induction period was 32 days, or 14 days for alkali contaminated material).

Spontaneously decomposes above 536 deg F (280 deg C) and will cause an explosive if confined. ... Air or oxygen is not required for decomposition or oxidation.

no data available

no data available

no data available

no data available

Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2,4-dinitrotoluene. ... There is sufficient evidence in experimental animals for the carcinogenicity of 2,4-dinitrotoluene. ... Overall evaluation: 2,4-Dinitrotoluene ... /is/ possibly carcinogenic to humans (Group 2B).

A significant reduction in sperm counts and normal sperm morphology was observed in one study of chronically exposed workers while several other studies did not report these effects. A small, but statistically significant, increase in spontaneous abortions was reported in one study of chronically exposed workers; several methodological problems with the study were noted. In animals orally exposed to 2,4-dinitrotoluene, decreased fertility was reported. Decreased sperm production, testicular atrophy, and degenerated seminiferous tubules were observed in males, and ovarian atrophy and dysfunction were observed in female rats. No birth defects were observed in the offspring of animals fed 2,4-dinitrotoluene in the diet.

The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the blood. This may result in the formation of methaemoglobin. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

AEROBIC: 2,4-Dinitrotoluene was reduced by 80%, of which 22% was transformed to 4-amino-2-nitrotoluene and 6% to 2-amino-4-nitrotoluene, by a mixture of microorganisms indigenous to an aquifer which underlies an explosives contaminated site(1); in the same study, approximately 28% of the 2,4-dinitrotoluene was mineralized to carbon dioxide within 28 days, while approximately 20% was not degraded within 28 days(1). In a wastewater treatment plant handling munitions wastewater, aerobic biodegradation of 2,4-dinitrotoluene was accelerated by addition of ethanol and phosphate(2); 4-amino-2-nitrotoluene and 2-amino-4-nitrotoluene were consistently observed as the main biodegradation reduction products(2). 2,4-Dinitrotoluene, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test that suggests the compound is not readily biodegradable(3). In soil column studies using a munitions plant soil previously exposed to 2,4-nitrotoluene, 2,4-nitrotoluene biodegradation of 2,4-dinitrotoluene was rapid in the presence of natural mineral water, but slower in the presence of deionized water(4).

Bioconcentration factor (weighted average) = 3.8 (calculated) for aquatic organisms that contain about 7.6% lipids.

In a loamy sand soil containing an organic matter content of 8.5 g/kg, 2,4-dinitrotoluene had measured Kd adsorption coefficients ranging from 0.28 to 1.11 cu cm/g(1) that correspond to a Koc range of 57 to 225(SRC). In three Chinese soils (organic carbon content of 0.47, 1.0 and 2.2%), measured Freundlich coefficients (Kf) for 2,4-dinitrotoluene ranged from 0.66 to 5.1 mmol-L/kg(2) that correspond to a Koc range of approximately 200 to 1000(SRC). Using a structure estimation method based on molecular connectivity indices(3), the Koc for 2,4-dinitrotoluene can be estimated to be 575(SRC). According to a classification scheme(4), a Koc range of 57-1000 suggests that 2,4-dinitrotoluene can have a high to low mobility range in soil. Leaching of 2,4-dinitrotoluene has been observed in soil column transport studies(5).

no data available

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN3454 (For reference only, please check.)

IMDG: UN3454 (For reference only, please check.)

IATA: UN3454 (For reference only, please check.)

ADR/RID: DINITROTOLUENES, SOLID (For reference only, please check.)

IMDG: DINITROTOLUENES, SOLID (For reference only, please check.)

IATA: DINITROTOLUENES, SOLID (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

no data available

no data available

Commercial grades of DNT typically consist of a mixture of all 6 isomers, but mainly 2,4-DNT(78%) and 2,6-DNT (19%).Other UN-number: 1600 (molten).Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Do NOT take working clothes home.See ICSCs 0727 and 0728.