Chemical Safety Data Sheet MSDS / SDS

DL-α-Tocopherol

Revision Date:2024-04-13Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: DL-α-Tocopherol
  • CBnumber: CB5275357
  • CAS: 10191-41-0
  • EINECS Number: 233-466-0
  • Synonyms: DL-Alpha-Tocopherol,DL-α-Tocopherol

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

Classification of the substance or mixture

Skin sensitization, Sub-category 1B

Label elements

Pictogram(s)
  • Signal wordDanger
Hazard statement(s)

H225 Highly Flammable liquid and vapour

H370 Causes damage to organs

Precautionary statement(s)

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378 In case of fire: Use … for extinction.

P403+P235 Store in a well-ventilated place. Keep cool.

Prevention

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

Storage

none

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards

no data available

SECTION 3: Composition/information on ingredients

Substance

  • Product name: DL-α-Tocopherol
  • Synonyms: DL-Alpha-Tocopherol,DL-α-Tocopherol
  • CAS: 10191-41-0
  • EC number: 233-466-0
  • MF: C29H50O2
  • MW: 430.71

SECTION 4: First aid measures

Description of first aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Most important symptoms and effects, both acute and delayed

no data available

Indication of any immediate medical attention and special treatment needed

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

SECTION 5: Firefighting measures

Extinguishing media

Wear self contained breathing apparatus for fire fighting if necessary.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

NFPA 704

2
1
1
HEALTH 2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE 1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT 1 Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Environmental precautions: Do not let product enter drains. Keep in suitable, closed containers for disposal.

SECTION 7: Handling and storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 deg C.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

Exposure controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical statePale yellow oil
  • ColourColourless to Dark Yellow to Thick
  • Odour

    Little or no odor

  • Melting point/freezing point

    2.5 - 3.5 °C.

  • Boiling point or initial boiling point and boiling range

    210 °C. Atm. press.:0.133 hPa.

  • Flammability

    no data available

  • Lower and upper explosion limit/flammability limit

    no data available

  • Flash point

    254 °C. Atm. press.:1 013 hPa.

  • Auto-ignition temperature

    420 °C. Remarks:No further data has been documented for pressure.

  • Decomposition temperature

    no data available

  • pH

    no data available

  • Kinematic viscosity

    no data available

  • SolubilityH2O: insoluble
  • Partition coefficient n-octanol/water

    log Pow = 12.18. Temperature:25 °C. Remarks:The substance is within the applicability domain of the model.

  • Vapour pressure

    0 hPa. Temperature:60 °C. Remarks:Extrapolated.;0 hPa. Temperature:20 °C.

  • Density and/or relative density

    0.95. Temperature:25 °C.

  • Relative vapour density

    no data available

  • Particle characteristics

    no data available

SECTION 10: Stability and reactivity

Reactivity

no data available

Chemical stability

Unstable to UV light, alkalies, and oxidation. Tocopherol

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

Carbon oxides

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 - rat (male/female) - > 4 000 mg/kg bw. Remarks:4 out of 10 animals died.
  • Inhalation: no data available
  • Dermal: LD50 - rat (male/female) - > 3 000 mg/kg bw.

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

SECTION 12: Ecological information

Toxicity

  • Toxicity to fish: LC50 - Oncorhynchus mykiss (previous name: Salmo gairdneri) - > 11 mg/L - 96 h.
  • Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 23.53 mg/L - 48 h.
  • Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - > 25.8 mg/L - 72 h.
  • Toxicity to microorganisms: EC20 - activated sludge, domestic - > 927 mg/L - 30 min. Remarks:Respiration rate.

Persistence and degradability

PURE CULTURE: Vitamin E was biodegraded by aerobic bacterial communities (genera Idiomarina and Bacillus), isolated from marine sediment and microbial mat sample(1); biodegradation appeared to involve an initial omega-oxidation of the isoprenoid side chain and subsequent beta-oxidation, affording 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman(1).

Bioaccumulative potential

An estimated BCF of 39 was calculated in fish for vitamin E(SRC), using an estimated log Kow of 12.2(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not metabolized by the organism(SRC).

Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of vitamin E can be estimated to be 2.5X10+7(SRC). According to a classification scheme(2), this estimated Koc value suggests that vitamin E is expected to be immobile in soil.

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Transport hazard class(es)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Packing group, if applicable

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed.
EC Inventory
Listed.
United States Toxic Substances Control Act (TSCA) Inventory
Listed.
China Catalog of Hazardous chemicals 2015
Not Listed.
New Zealand Inventory of Chemicals (NZIoC)
Listed.
PICCS
Listed.
Vietnam National Chemical Inventory
Listed.
IECSC
Listed.
Korea Existing Chemicals List (KECL)
Listed.

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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