Chemical Safety Data Sheet MSDS / SDS

1,2-Dimethoxyethane

Revision Date:2023-12-09Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 1,2-Dimethoxyethane
  • CBnumber: CB9232185
  • CAS: 110-71-4
  • EINECS Number: 203-794-9
  • Synonyms: DME,1,2-dimethoxyethane

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P501 Dispose of contents/container to..…
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P370+P378 In case of fire: Use … for extinction.
Hazard statements
H360 May damage fertility or the unborn child
H332 Harmful if inhaled
H315 Causes skin irritation
H302 Harmful if swallowed
H225 Highly Flammable liquid and vapour

SECTION 3: Composition/information on ingredients

Substance

  • Product name: 1,2-Dimethoxyethane
  • Synonyms: DME,1,2-dimethoxyethane
  • CAS: 110-71-4
  • EC number: 203-794-9
  • MF: C4H10O2
  • MW: 90.12

SECTION 4: First aid measures

Description of first aid measures

General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Pay attention to flashback.

Vapors are heavier than air and may spread along floors. Risk of dust explosion.

Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

1
3
0
HEALTH 1 Exposure would cause irritation with only minor residual injury (e.g. acetone, sodium bromate, potassium chloride)
FIRE 3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons.

Test for peroxide formation periodically and before distillation.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact Material: Viton?

Minimum layer thickness: 0,7 mm Break through time: 480 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,4 mm Break through time: 10 min

Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

required when vapours/aerosols are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type: Filter type ABEK

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancecolorless liquid, clear
  • Odourether-like
  • Odour Thresholdnot determined
  • pHca.7neutral
  • Melting point/freezing pointMelting point/range: -58 °C - lit.
  • Initial boiling point and boiling range85 °C - lit.
  • Flash point5 °C - closed cup
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limits Upper explosion limit: 10,4 %(V) Lower explosion limit: 1,6 %(V)
  • Vapour pressure 87 hPa at 25 °C - OECD Test Guideline 104
  • Vapour density 3,11 - (Air = 1.0)
  • Relative density0,867 g/cm3 at 25 °C - lit. 0,87 at 20 °C - OECD Test Guideline 109
  • Water solubility1.000 g/l at 25 °C - soluble
  • Partition coefficient: n-octanol/waterlog Pow: -0,21 at 25 °C - (experimental) - Bioaccumulation is not expected.
  • Autoignition temperatureNo data available
  • Decomposition temperatureNo data available
  • ViscosityViscosity, kinematic: 0,48 mm2/s at 20 °C - OECD Test Guideline 114 Viscosity, dynamic: 0,42 mPa.s at 20 °C - OECD Test Guideline 114
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available
  • λmaxλ: 220 nm Amax: 1.00
    λ: 250 nm Amax: 0.20
    λ: 300 nm Amax: 0.03
    λ: 350-400 nm Amax: 0.01

Other safety information

Surface tension 70,7 mN/m at 1g/l at 23 °C

- OECD Test Guideline 115

Relative vapor density

3,11 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Formation of peroxides possible.

Vapors may form explosive mixture with air.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) . Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

Warming. Moisture.

Incompatible materials

Oxidizing agents, Strong acids, Strong oxidizing agents

Hazardous decomposition products

Peroxides

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Rat - female - 5.370 mg/kg (OECD Test Guideline 401)
Acute toxicity estimate Inhalation - 11,1 mg/l (Expert judgment)
Remarks: (Regulation (EC) No 1272/2008, Annex VI) Acute toxicity estimate Inhalation - 11,1 mg/l (Expert judgment)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
LD50 Dermal - Rat - female - > 5.000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Irritating to skin. - 24 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 24 h (OECD Test Guideline 405)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative
(OECD Test Guideline 429)
Remarks: The value is given in analogy to the following substances: 1-ethoxy-2-(2- methoxyethoxy)ethane
Germ cell mutagenicity
Not mutagenic in Ames Test. Did not show mutagenic effects in animal experiments. Test Type: unscheduled DNA synthesis assay
Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 482
Result: negative
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: sister chromatid exchange assay Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 479
Result: positive
Test Type: In vivo micronucleus test Species: Mouse
Cell type: Bone marrow Application Route: Oral
Method: OECD Test Guideline 474 Result: negative
Test Type: Chromosome aberration test Species: Chinese hamster
Cell type: Bone marrow Application Route: Oral
Method: OECD Test Guideline 475 Result: negative
Carcinogenicity
No data available
Reproductive toxicity
May damage the unborn child. May damage fertility.
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No aspiration toxicity classification

SECTION 12: Ecological information

Toxicity

Toxicity to fish
static test LC50 - Danio rerio (zebra fish) - > 5.000 mg/l - 96 h (OECD Test Guideline 203)

Remarks: The value is given in analogy to the following substances: Tegdme


Toxicity to daphnia and other aquatic invertebrates

semi-static test EC50 - Daphnia magna (Water flea) - 4.000 mg/l - 48 h

(OECD Test Guideline 202)

Toxicity to algae
static test ErC50 - Pseudokirchneriella subcapitata (green algae) -

9.120 mg/l - 72 h

(OECD Test Guideline 201)

Toxicity to bacteria
static test EC50 - activated sludge - > 6.400 mg/l - 3 h (OECD Test Guideline 209)

Persistence and degradability

Biodegradability aerobic - Exposure time 48 d

Result: 16 % - According to the results of tests of biodegradability this product is not readily biodegradable.

(OECD Test Guideline 302B)

Chemical Oxygen Demand (COD)

1.700 mg/g

Remarks: (External MSDS)

Bioaccumulative potential

Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected.

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14: Transport information

UN number

ADR/RID: 2252 IMDG: 2252 IATA: 2252

UN proper shipping name


ADR/RID: 1,2-DIMETHOXYETHANE IMDG: 1,2-DIMETHOXYETHANE


IATA: 1,2-Dimethoxyethane

14.3

Transport hazard class(es)

ADR/RID: 3 IMDG: 3


IATA: 3

14.4

Packaging group

ADR/RID: II IMDG: II


IATA: II

14.5

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no


IATA: no

14.6

Special precautions for user

No data available


SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
EC Inventory:Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Check for peroxides prior to distillation; eliminate if found.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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