Chemical Safety Data Sheet MSDS / SDS


Revision Date:2024-03-30Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Estrone
  • CBnumber: CB5741416
  • CAS: 53-16-7
  • EINECS Number: 200-164-5
  • Synonyms: estrone,oestrone

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

Classification of the substance or mixture

Carcinogenicity, Category 2

Reproductive toxicity, Category 1A

Reproductive toxicity, Additional category for effects on or via lactation

Label elements

  • Signal wordDanger
Hazard statement(s)

H225 Highly Flammable liquid and vapour

H351 Suspected of causing cancer

H360 May damage fertility or the unborn child

H362 May cause harm to breast-fed children

H370 Causes damage to organs

Precautionary statement(s)

P201 Obtain special instructions before use.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P263 Avoid contact during pregnancy/while nursing.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P281 Use personal protective equipment as required.

P311 Call a POISON CENTER or doctor/physician.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P370+P378 In case of fire: Use … for extinction.


P203 Obtain, read and follow all safety instructions before use.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P263 Avoid contact during pregnancy and while nursing.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.


P318 IF exposed or concerned, get medical advice.


P405 Store locked up.


P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards

no data available

SECTION 3: Composition/information on ingredients


  • Product name: Estrone
  • Synonyms: estrone,oestrone
  • CAS: 53-16-7
  • EC number: 200-164-5
  • MF: C18H22O2
  • MW: 270.37

SECTION 4: First aid measures

Description of first aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Most important symptoms and effects, both acute and delayed

no data available

Indication of any immediate medical attention and special treatment needed

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Poisons A and B

SECTION 5: Firefighting measures

Extinguishing media

Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials. ... As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Wear approved respiratory protection, chemically compatible gloves, and protective clothing. Wipe up spillage or collect spillage using a high-efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site.

SECTION 7: Handling and storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store in the original package. Do not store above 25 deg C.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

Exposure controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical stateCrystalline Powder or Crystals
  • ColourWhite to almost white
  • Odour


  • Melting point/freezing point


  • Boiling point or initial boiling point and boiling range


  • Flammability

    no data available

  • Lower and upper explosion limit/flammability limit

    no data available

  • Flash point


  • Auto-ignition temperature

    no data available

  • Decomposition temperature

    no data available

  • pH

    no data available

  • Kinematic viscosity

    no data available

  • SolubilityChloroform (Slightly), Dioxane (Slightly), Ethanol (Slightly), Methanol (Slightl
  • Partition coefficient n-octanol/water

    no data available

  • Vapour pressure

    2.49X10-10 mm Hg at 25 deg C (est)

  • Density and/or relative density

    1.164 g/cm3

  • Relative vapour density

    no data available

  • Particle characteristics

    no data available

SECTION 10: Stability and reactivity


no data available

Chemical stability

Stable in air.

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

no data available

Hazardous decomposition products

When heated to decomposition it emits acrid smoke and fumes.

SECTION 11: Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


Estrogens, Steroidal: known to be human carcinogens. Estrogens, Steroidal

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

SECTION 12: Ecological information


  • Toxicity to fish: EC50; Species: Danio rerio (Zebra danio, age 20 days posthatch); Conditions: freshwater, renewal, 26 deg C; Concentration: 0.078 ug/L for 18 days; Effect: whole body vitellogenin induction /100% purity
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

Persistence and degradability

AEROBIC: Estrone exhibited approximately 38% mineralization in 33 days using 4 Mile Creek sediment, 56% mineralization in 33 days using Boulder Creek sediment, and up 90% mineralization using South Platte River sediments, Colorado. Sediments were collected downstream of local waste water treatment plants. Upstream sediments exhibited approximately 1, 1, and 1% mineralization, respectively(1). Estrone is biodegraded by sewage bacteria via ring cleavage, ultimately to carbon dioxide through a tricarboxylic acid cycle(2). C14-labeled estrone, present at 0.1 mg/kg, reached 2.0-17.4% mineralization in 21 days using natural German and Austrian soils in microcosm incubations maintained at 20 deg C(3,4). Soil-specific percent 14CO2 evolution values of 5.4, 4.6, 11.1, 2.0, and 17.4 were reported using Metelan (grassland, 3.3% SOC), Koeln (crop field, 0.7% SOC), Halle (crop field, 1.3% SOC), Gumpenstein (crop field, 2.2% SOC), and Hamapil (orchard, 1.5% SOC) soil microcosms, respectively(4).

Bioaccumulative potential

An estimated BCF of 54 was calculated in fish for estrone(SRC), using a log Kow of 3.13(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

Mobility in soil

The Koc of estrone was reported as 2,000-18,000, using a Chelsea, MI topsoil (total organic carbon 5.45%)(1). Natural estrogens such as estrone are mainly removed from the aqueous phase by adsorption onto solids such as sludge in wastewater or soil in cases of land application(2). Sorption of estrone from CaCl2 solution and artificial urine in pastoral soils from North Island, New Zealand was studied. The log Koc values using Horotiu silt loam (pH 5.4; % OC 8.2; % Sand 34; % Silt 48; % Clay 17), Hamilton clay loam (pH 5.1; % OC 4; % Sand 19; % Silt 51; % Clay 30), and TeKowhai silt loam (pH 5.1; % OC 5; % Sand 9; % Silt 54; % Clay 37) were 2.66 and 2.75, 2.93 and 3.04, and 3.15 and 2.9, respectively(3), corresponding to Koc values of 457 and 562, 851 and 1096, and 1412 and 794, respectively(SRC). According to a classification scheme(4), these Koc values suggest that estrone mobility in soil is moderate to immobile. In soils with a long history of treatment with manure, biosolids, or wastewater, sorption of estrone becomes dependent on soil organic carbon content (SOC). Kd values of 122, 46, 134, 72, and 67 mL/g were reported using Metelan (grassland, SOC 3.3%), Koeln (crop field, 0.7% SOC), Halle (crop field, 1.3% SOC), Gumpenstein (crop field, 2.2% SOC), and Hamapil (orchard, 1.5% SOC) soils in Germany, respectively(5). A Kd of 402 L/kg was reported using activated sludge(6).

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Transport hazard class(es)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Packing group, if applicable

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Environmental hazards




Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)
EC Inventory
United States Toxic Substances Control Act (TSCA) Inventory
China Catalog of Hazardous chemicals 2015
Not Listed.
New Zealand Inventory of Chemicals (NZIoC)
Not Listed.
Vietnam National Chemical Inventory
Not Listed.
Korea Existing Chemicals List (KECL)
Not Listed.

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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