Chemical Safety Data Sheet MSDS / SDS
ETHYL ACETOACETATE (1,3-13C2)
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: ETHYL ACETOACETATE (1,3-13C2)
- CBnumber: CB5394254
- CAS: 77504-73-5
- Synonyms: Ethyl acetoacetate-1,3-13C?;Ethyl acetoacetate (1,3-13C?, 99%)
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P271 Use only outdoors or in a well-ventilated area.
P264 Wash skin thouroughly after handling.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
Hazard statements
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H315 Causes skin irritation
Substance
- Product name: ETHYL ACETOACETATE (1,3-13C2)
- Synonyms: Ethyl acetoacetate-1,3-13C?;Ethyl acetoacetate (1,3-13C?, 99%)
- CAS: 77504-73-5
- MF: C6H10O3
- MW: 132.16
4.1 Description of first-aid measures
If inhaledAfter inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaWater Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on protection against fire and explosionKeep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Change contaminated clothing. Wash hands after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed.
Storage class
Storage class (TRGS 510): 10: Combustible liquids
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsChange contaminated clothing. Wash hands after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 30 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Internet: www.kcl.de).
Full contact
Material: butyl-rubber
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Butoject® (KCL 898)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 30 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Respiratory protection
Not required; except in case of aerosol formation.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorNo data available
- c) OdorNo data available
- d) Melting point/freezing pointMelting point/range: -43 °C - lit.
- e) Initial boiling point and boiling range181 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point84 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityNo data available
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.045 g/mL at 25 °C 1.045 g/cm3 at 25 °C
- Relative density1.045 g/mL at 25 °C
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
Strong acids
Strong bases
Strong oxidizing agents
Strong acids
Strong bases
10.3 Conditions to avoid
Strong heating.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - female - 10,800 mg/kg (OECD Test Guideline 401)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
LC50 Inhalation - Rabbit - male and female - 4 h - > 49.2 mg/l - vapor
Remarks: (ECHA)
The value is given in analogy to the following substances: methyl acetate
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Skin corrosion/irritation
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
LC50 Inhalation - Rabbit - male and female - 4 h - > 49.2 mg/l - vapor
Remarks: (ECHA)
The value is given in analogy to the following substances: methyl acetate
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Serious eye damage/eye irritation
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Eyes - Rabbit
Result: No eye irritation - 24 h (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Respiratory or skin sensitization
Result: No eye irritation - 24 h (OECD Test Guideline 405)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Freund's complete adjuvant test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: ethyl acetoacetateTest
Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: ethyl acetoacetateCarcinogenicity
No data available
Reproductive toxicity
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: ethyl acetoacetateTest
Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: ethyl acetoacetateCarcinogenicity
No data available
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 28 d - NOAEL (No observed adverse effect level) - 1,000 mg/kg
Remarks: Subacute toxicity
No significant adverse effects were reported
The value is given in analogy to the following substances: ethyl acetoacetate
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
Headache
Dizziness
Nausea
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Remarks: Subacute toxicity
No significant adverse effects were reported
The value is given in analogy to the following substances: ethyl acetoacetate
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption:
Headache
Dizziness
Nausea
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
12.1 Toxicity
Toxicity to fish semi-static test LC50 - Danio rerio (zebra fish) - > 100 mg/l - 96 h (OECD Test Guideline 203)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 100 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Toxicity to algae static test ErC50 - Desmodesmus subspicatus (green algae) - > 100 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
12.2 Persistence and degradability
Biodegradability aerobic Chemical oxygen demand - Exposure time 28 d
Result: 66 % - Readily biodegradable.
(OECD Test Guideline 301D)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
Result: 66 % - Readily biodegradable.
(OECD Test Guideline 301D)
Remarks: The value is given in analogy to the following substances: ethyl acetoacetate
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
Discharge into the environment must be avoided.
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222223531
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222223531
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.