ChemicalBook
Chemical Safety Data Sheet MSDS / SDS

Ethyl glyoxalate

Revision Date:2026-04-26Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Ethyl glyoxalate
  • CBnumber: CB4173766
  • CAS: 924-44-7
  • EINECS Number: 213-105-3
  • Synonyms: ethyl 2-oxoacetate,Ethyl glyoxylate

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 010-86108875

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P308+P313 IF exposed or concerned: Get medical advice/attention.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Hazard statements
H317 May cause an allergic skin reaction
H315 Causes skin irritation
H225 Highly Flammable liquid and vapour

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Ethyl glyoxalate
  • Synonyms: ethyl 2-oxoacetate,Ethyl glyoxylate
  • CAS: 924-44-7
  • EC number: 213-105-3
  • MF: C4H6O3
  • MW: 102.09

SECTION 4: First aid measures

First Aid Measures

General advice
Consult a physician if necessary. Remove to fresh air.
Eye contact
Wash with plenty of water.
Skin Contact
Wash skin with soap and water.
Inhalation
Remove to fresh air If breathing is difficult, give oxygen If not breathing, give artificial respiration
Ingestion
Never give anything by mouth to an unconscious person. Clean mouth with water.

Most important symptoms and effects, both acute and delayed

Symptoms
No information available.

Indication of any immediate medical attention and special treatment needed

Note to physicians
Treat symptomatically.

SECTION 5: Firefighting measures

Suitable Extinguishing Media

Suitable Extinguishing Media
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable Extinguishing Media
No information available.

Specific hazards arising from the chemical

Specific hazards arising from the chemical
No information available.
Hazardous combustion products
Carbon oxides.

Explosion data

Sensitivity to Mechanical Impact
No information available.
Sensitivity to Static Discharge
No information available.

Protective equipment and precautions for firefighters

Protective equipment and precautions for firefighters
As in any fire, wear self contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal precautions
Ensure adequate ventilation, especially in confined areas.

Environmental precautions

Environmental precautions
See Section 12 for additional Ecological Information.

Methods and material for containment and cleaning up

Methods for containment
Prevent further leakage or spillage if safe to do so.
Methods for cleaning up
Pick up and transfer to properly labeled containers.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling
Handle in accordance with good industrial hygiene and safety practice.

Conditions for safe storage, including any incompatibilities

Storage Conditions
Keep containers tightly closed in a dry, cool and well-ventilated place. Store at room temperature.
Incompatible materials
None known based on information supplied.

SECTION 8: Exposure controls/personal protection

Control parameters

Exposure Guidelines
.
Other Information
Vacated limits revoked by the Court of Appeals decision in AFL-CIO v. OSHA, 965 F.2d 962 (11th Cir., 1992).
Column 1Column 2Column 3Column 4
Toluene 108-88-3TWA: 20 ppmTWA: 200 ppm (vacated) TWA: 100 ppm (vacated) TWA: 375 mg/m3 (vacated) STEL: 150 ppm (vacated) STEL: 560 mg/m3
Ceiling: 300 ppm		IDLH: 500 ppm
TWA: 100 ppm
TWA: 375 mg/m3
STEL: 150 ppm
STEL: 560 mg/m3
NIOSH IDLH Immediately Dangerous to Life or Health

Appropriate engineering controls

Engineering Controls
Showers
Eyewash stations
Ventilation systems

Individual protection measures, such as personal protective equipment

Eye/face protection
Wear safety glasses with side shields (or goggles).
Skin and Body Protection
Wear protective gloves and protective clothing.
Respiratory protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations.
General Hygiene Considerations
Handle in accordance with good industrial hygiene and safety practice.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical Stateliquid
  • AppearanceNo information available
  • OdorNo information available
  • pHNo information available
  • Melting point/freezing pointNo information available
  • Boiling point111 °C
  • Flash point4 °C CC (closed cup)
  • Liquid DensityNo information available
  • Evaporation rateNo information available
  • Upper flammability limitsNo information available
  • Lower flammability limitNo information available
  • Vapor pressureNo information available
  • Vapor densityNo information available
  • Specific gravityNo information available
  • Water solubilityImmiscible with water.
  • Solubility in other solventsNo information available
  • Partition coefficientNo information available
  • Autoignition temperatureNo information available
  • Decomposition temperatureNo information available
  • Kinematic viscosityNo information available
  • Explosive propertiesNo information available
  • Oxidizing propertiesNo information available
  • Density and/or relative density1.03 g/mL at 20 °C
  • SolubilityChloroform, Ethyl Acetate
  • ColourClear Colorless

SECTION 10: Stability and reactivity

Reactivity

Not applicable

Chemical stability

Stable under recommended storage conditions.

Possibility of Hazardous Reactions

None under normal processing.

Hazardous polymerization

No information available.

Conditions to avoid

Extremes of temperature and direct sunlight.

Incompatible materials

Strong oxidizing agents.

Hazardous Decomposition Products

Carbon oxides.

SECTION 11: Toxicological information

Information on likely routes of exposure

Inhalation
Classified based on available data. For more details, see section 2.
Eye contact
Classified based on available data. For more details, see section 2.
Skin Contact
Classified based on available data. For more details, see section 2.
Ingestion
Classified based on available data. For more details, see section 2.

Information on toxicological effects

Symptoms
Classified based on available data. For more details, see section 2.

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Chronic Toxicity
May cause adverse liver effects. Target Organ Effects Central nervous system, Eyes, Respiratory system, Kidney, Liver, Skin. Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Chemical name ACGIH IARC NTP OSHA

Toluene - Group
3 - - 108-88-3

Numerical measures of toxicity - Product Information

Unknown acute toxicity
50% of the mixture consists of ingredient(s) of unknown toxicity
The following values are calculated based on chapter 3.1 of the GHS document
ATEmix (oral)
2600 mg/kg
ATEmix (dermal)
12000 mg/kg
ATEmix (inhalation-dust/mist)
12.5 mg/l
ATEmix (inhalation-vapor)
12.5 mg/l

SECTION 12: Ecological information

Ecotoxicity

Chemical nameAlgae/aquatic plantsFishToxicity to
Microorganisms		Crustacea
Toluene 108-88-312.5: 72 h
Pseudokirchneriella subcapitata mg/L EC50 static 433: 96 h
Pseudokirchneriella subcapitata mg/L EC50		15.22 - 19.05: 96 h
Pimephales promelas mg/L
LC50 flow-through 12.6: 96 h
Pimephales promelas mg/L
LC50 static 5.89 - 7.81: 96 h
Oncorhynchus mykiss mg/L
LC50 flow-through 14.1 - 17.16: 96 h Oncorhynchus mykiss mg/L LC50 static 50.87 - 70.34: 96 h Poecilia reticulata mg/L LC50 static 11.0 - 15.0: 96 h Lepomis macrochirus mg/L LC50 static 54: 96 h Oryzias latipes mg/L LC50 static 28.2: 96 h Poecilia reticulata mg/L LC50 semi-static 5.8: 96 h Oncorhynchus mykiss mg/L LC50 semi-static		-11.5: 48 h Daphnia magna mg/L EC50 5.46 - 9.83: 48 h
Daphnia magna mg/L EC50
Static
Toluene 108-88-32.7
50% of the mixture consists of components(s) of unknown hazards to the aquatic environment.

Toluene 12.5: 72 h

15.22 - 19.05: 96 h - 11.5: 48 h Daphnia magna

static 433: 96 h

Pimephales promelas mg/L Static

Persistence and degradability No information available. Bioaccumulation No information available. Mobility No information available.

Toluene

2.7 108-88-3

SECTION 13: Disposal considerations

Disposal of wastes Disposal should be in accordance with applicable regional, national and local laws and regulations. Contaminated packaging Do not reuse container. California Hazardous Waste Status This product contains one or more substances that are listed with the State of California as a hazardous waste.

Toluene

Toxic

SECTION 14: Transport information

DOT

UN/ID no
UN1294
Hazard Class
3
Packing Group
II
Proper shipping name
Toluene Reportable Quantity (RQ) (Toluene: RQ (kg)= 0.454)
Description
UN1294, Toluene, 3, II
Emergency Response Guide Number
130

IMDG

UN/ID no
UN1294
Hazard Class
3
Packing Group
II
Proper shipping name
Toluene
Description
UN1294, Toluene, 3, II, (4°C c.c.)
EmS-No
F-E, S-D

IATA

UN/ID no
UN1294
Hazard Class
3
Packing Group
II
Proper shipping name
Toluene
Description
UN1294, Toluene, 3, II
ERG Code
3L

SECTION 15: Regulatory information

International Inventories

All of the components in the product are on the following Inventory lists
TSCA (United States): Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP) South Korea (KECL): Philippines (PICCS)
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
Chemical nameTSCADSLNDSLEINECSELINCSENCSIECSCKECLPICCSAICS
TolueneXX-X-XXXXX
Ethyl glyoxalateX-XX---XX-

US Federal Regulations

SARA 313

Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.

SARA 311/312 Hazard Categories

Acute health hazard
Yes
Chronic Health Hazard
Yes
Fire hazard
Yes
Sudden release of pressure hazard
No
Reactive hazard
No

CWA (Clean Water Act)

This product contains the following substances which are regulated pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42).
Chemical nameCWA - Reportable
Quantities		CWA - Toxic PollutantsCWA - Priority PollutantsCWA - Hazardous
Substances
Toluene 108-88-31000 lbXXX

US State Regulations

California Proposition 65

This product contains the following Proposition 65 chemicals.
Chemical name California Proposition 65
Chemical name
Toluene - 108-88-3

U.S. State Right-to-Know Regulations

Chemical nameNew JerseyMassachusettsPennsylvania
Toluene 108-88-3XXX

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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