Chemical Safety Data Sheet MSDS / SDS

m-Xylene

Revision Date:2024-03-16Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: m-Xylene
CBnumber: CB4852746
CAS: 108-38-3
EINECS Number: 203-576-3
Synonyms: m-xylene,1,3-Dimethylbenzene

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P370+P378 In case of fire: Use … for extinction.

P331 Do NOT induce vomiting.

P311 Call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

Hazard statements

H335 May cause respiratory irritation

H370 Causes damage to organs

H412 Harmful to aquatic life with long lasting effects

H332 Harmful if inhaled

H319 Causes serious eye irritation

H315 Causes skin irritation

H312 Harmful in contact with skin

H304 May be fatal if swallowed and enters airways

H226 Flammable liquid and vapour

H225 Highly Flammable liquid and vapour

SECTION 3: Composition/information on ingredients

Substance

Product name: m-Xylene
Synonyms: m-xylene,1,3-Dimethylbenzene
CAS: 108-38-3
EC number: 203-576-3
MF: C8H10
MW: 106.17

SECTION 4: First aid measures

Description of first aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary failure possible after aspiration of vomit. Call a physician immediately.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Carbon dioxide (CO2) Foam Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air at elevated temperatures.

Development of hazardous combustion gases or vapours possible in the event of fire.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	2	Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE	3	Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact Material: Viton?

Minimum layer thickness: 0,7 mm Break through time: 480 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,4 mm Break through time: 30 min

Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

Exposure limits

NIOSH REL: 100 ppm (435 mg/m³), STEL 150 ppm (655 mg/m³), IDLH 900 ppm; OSHA PEL: TWA 100 ppm; ACGIH TLV: TWA 100 ppm, STEL 150 ppm (adopted).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolorless liquid
OdourNo data available
Odour Threshold0.041ppm
pHNo data available
Melting point/freezing pointMelting point/range: -48 °C - lit.
Initial boiling point and boiling range138 - 139 °C - lit.
Flash point27 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limits Upper explosion limit: 7 %(V) Lower explosion limit: 1,1 %(V)
Vapour pressure 13,78 hPa at 29,4 °C
Vapour density 3.7 (vs air)
Relative density0,868 g/cm3 at 25 °C - lit. 0,86 at 25 °C
Water solubility146 g/l at 25 °C - partly soluble
Partition coefficient: n-octanol/waterlog Pow: 3,2 at 20 °C - Bioaccumulation is not expected.
Autoignition temperature528,0 °C at 1.013 hPa
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 0,58 mPa.s at 25 °C
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant14.80 at 45.00 °C, 17.26.4 at 50.00 °C, 19.90 at 55.00 °C, 23.01.3 at 60.00 °C, 27.46.3 at 70.00 °C (static headspace-GC, Park et al., 2004)

Other safety information

Surface tension 28,47 mN/m at 25 °C

SECTION 10: Stability and reactivity

Reactivity

Vapor/air-mixtures are explosive at intense warming.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Violent reactions possible with: Strong oxidizing agents

conc. sulfuric acid Nitric acid

uranium hexafluoride sulfur

Conditions to avoid

Heating.

Incompatible materials

rubber, various plastics

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male - 3.523 mg/kg
(EC Directive 92/69/EEC B.1 Acute Toxicity (Oral))
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
LC50 Inhalation - Rat - male and female - 4 h - 27,12 mg/l (US-EPA)
Symptoms: Inhalation may lead to the formation of oedemas in the respiratory tract. Dermal: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)

Skin corrosion/irritation

Skin - Rabbit
Result: Moderate skin irritation - 4 h (Regulation (EC) No. 440/2008, Annex, B.4)
Drying-out effect resulting in rough and chapped skin. After long-term exposure to the chemical: Dermatitis

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Severe eye irritation - 24 h Remarks: (RTECS)

Respiratory or skin sensitization

(OECD Test Guideline 429)

Germ cell mutagenicity

Test Type: sister chromatid exchange assay Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: Regulation (EC) No. 440/2008, Annex, B.19 Result: negative
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Remarks: (National Toxicology Program)
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: Mutagenicity (in vitro mammalian cytogenetic test) Result: negative
Test Type: dominant lethal test Species: Mouse
Application Route: Subcutaneous Method: OECD Test Guideline 478 Result: negative
Test Type: Mutagenicity (mammal cell test): micronucleus. Species: Mouse
Cell type: Red blood cells (erythrocytes) Application Route: Intraperitoneal Method: OECD Test Guideline 474 Result: negative
Remarks: (IUCLID)

Carcinogenicity

No data available

Reproductive toxicity

Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.

Specific target organ toxicity - single exposure

Inhalation - May cause respiratory irritation.

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

May be fatal if swallowed and enters airways.

Toxicity

LD50 orally in rats: 7.71 ml/kg (Smyth)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

static test LC50 - Oncorhynchus mykiss (rainbow trout) - 2,60 mg/l

- 96 h

(OECD Test Guideline 203)

Toxicity to algae

static test EC50 - Pseudokirchneriella subcapitata - 4,36 mg/l - 73 h (OECD Test Guideline 201)

Toxicity to bacteria

Remarks: (ECHA)

(m-xylene)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 98 % - Readily biodegradable. (OECD Test Guideline 301F)

Chemical Oxygen Demand (COD)

Theoretical oxygen demand

2,62 g/g Remarks: (ECHA)

3,17 g/g Remarks: (ECHA)

Ratio BOD/ThBOD 80 %

Remarks: (ECHA)

Bioaccumulative potential

Bioaccumulation Oncorhynchus mykiss (rainbow trout) - 56 d

at 10 °C - 1,3 mg/l(m-xylene)

Bioconcentration factor (BCF): 7,4 - 18,5

Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected.

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Incompatibilities

Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Electrostatic charges can be generated from agitation or flow.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.

SECTION 14: Transport information

UN number

ADR/RID: 1307 IMDG: 1307

UN proper shipping name

ADR/RID: XYLENES IMDG: XYLENES IATA: Xylenes

Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

Packaging group

ADR/RID: III IMDG: III IATA: III

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

EC Inventory:Listed.

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is indicated.The recommendations on this Card also apply to technical xylene.See ICSCs 0084 and 0086.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.