Methyl isothiocyanate

Acute toxicity - Category 3, Oral

Skin corrosion, Sub-category 1B

Skin sensitization, Category 1

Acute toxicity - Category 3, Inhalation

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

H301 Toxic if swalloed

H310 Fatal in contact with skin

H314 Causes severe skin burns and eye damage

H317 May cause an allergic skin reaction

H331 Toxic if inhaled

H400 Very toxic to aquatic life

H410 Very toxic to aquatic life with long lasting effects

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P273 Avoid release to the environment.

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P316 Get emergency medical help immediately.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P333+P317 If skin irritation or rash occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P391 Collect spillage.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

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Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Rinse with pure water for at least 15 minutes. Consult a doctor.

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg. (EPA, 1998)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Isocyanates, aliphatic thiocyanates, and related compounds

Evacuation: If fire becomes uncontrollable or container is exposed to direct flame - consider evacuation of one-third (1/3) mile radius.

Non-Specific -- Pesticide, Solid, n.o.s.) This material may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated it emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks. (EPA, 1998)

Wear self-contained breathing apparatus for firefighting if necessary.

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Decontamination of spilled isocyanates and disposal of isocyanate waste are best conducted by using aqueous ammonia (3-8% concentrated ammonia solution in 90-95% water with 0.2-5% liquid detergent) or aqueous sodium carbonate (5-10% sodium carbonate in 90-95% water and 0.2-5% liquid detergent). An alcoholic solution (50% ethanol, isopropyl alcohol, or butanol; 45% water; and 5% concentrated ammonia) may be preferred because of the low miscibility of isocyanates with water. Isocyanates

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Store only in closed original container to prevent leakage. Store only in cool, well-ventilated, locked areas, away form food and feedstuff, out of reach of children and irresponsible persons. Avoid exposure to heat and/or direct sunlight. Do not drop container onto or slide across sharp objects. MLPC Methylisothiocyanate (MITC)

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Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

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Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases.

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FlammableIsocyanates and thioisocyanates, such as METHYL ISOTHIOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

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Can react vigorously with oxidizing materials.

When heated to decomposition it emits very toxic fumes of /nitrogen oxides & sulfur oxides/.

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AEROBIC: In a soil biodegradation study, the biodegradation of methyl isothiocyanate generally followed first order kinetics in soils previously untreated with the compound(1). In soils previously exposed to methyl isothiocyanate, the biodegradation was generally much faster and the biodegradation did not follow first order kinetics(1). Even in soils that were previously untreated with methyl isothiocyanate, an accelerated transformation (which did follow first order kinetics) was observed after an initial period (8-15 days) of first order transformation(1). Using the first order kinetics, the biodegradation half-life was estimated to range from 0.5 to 50 days(2). Generally, the transformation was appreciably faster in soils that have been previously treated with the chemical frequently(2). At or above concentrations of 0.8 mg/L, methyl isothiocyanate inhibited nitrification in the activated sludge process of sewage disposal(2). Methyl isothiocyanate was confirmed to be biodegradable according to a Netherlands study that employed 10 soils under field conditions(3). Soil core samples from Dutch agricultural fields with a 4 year history of methyl isothiocyanate treatment were incubated with the test compound for 1 to 14 days at 20 deg C; 50% degradation times ranged from 0.5 to 9 days(3). In the laboratory, it was observed that methyl isothiocyanate biodegradation is influenced by factors such as nursery history, fumigant application rates, and freshness of tested soils(4). Methyl isothiocyanate, applied at 195-780 kg/hectacre and incubated at 22 deg C, exhibited half-lives of 3.14-11.20 days in Hayward, WI forest soils; half-lives in 3 Byromville, GA nursery soils ranged from 3.38-4.61 days(4).

An estimated BCF of 3 was calculated in fish for methyl isothiocyanate(SRC), using a log Kow of 0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of methyl isothiocyanate ranges from 3 to 14.5(1-4). According to a classification scheme(5), this Koc range suggests that methyl isothiocyanate is expected to have very high mobility in soil(SRC). Methyl isothiocyanate was shown to leach readily using repacked soil columns; nearly all the applied solution was recovered in the leachate(6). Using a soil column study that simulated environmental Moroccan conditions (0.84% organic matter, pH 7.6, 12.5% moisture, 4.28% clay, 12.32% loam, 83.41% sand), methyl isothiocyanate was shown to concentrate at the 0-40 cm soil layer within 24 hours(7).

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

ADR/RID: UN2477 (For reference only, please check.)

IMDG: UN2477 (For reference only, please check.)

IATA: UN2477 (For reference only, please check.)

ADR/RID: METHYL ISOTHIOCYANATE (For reference only, please check.)

IMDG: METHYL ISOTHIOCYANATE (For reference only, please check.)

IATA: METHYL ISOTHIOCYANATE (For reference only, please check.)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

ADR/RID: I (For reference only, please check.)

IMDG: I (For reference only, please check.)

IATA: I (For reference only, please check.)

ADR/RID: Yes

IMDG: Yes

IATA: Yes

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