Chemical Safety Data Sheet MSDS / SDS
Methylmagnesium Bromide
Revision Date:2026-04-04Revision Number:1
Product identifier
- Product name: Methylmagnesium Bromide
- CBnumber: CB4297592
- CAS: 75-16-1
- EINECS Number: 200-844-1
- Synonyms: MeMgBr,Methylmagnesium Bromide
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P403+P235 Store in a well-ventilated place. Keep cool.
P402+P404 Store in a dry place. Store in a closed container.
P370+P378 In case of fire: Use … for extinction.
P422 Store contents under …
P310 Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P231+P232 Handle under inert gas. Protect from moisture.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P501 Dispose of contents/container to..…
P335+P334 Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P271 Use only outdoors or in a well-ventilated area.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P240 Ground/bond container and receiving equipment.
P233 Keep container tightly closed.
P405 Store locked up.
P309 IF exposed or if you feel unwell:
Hazard statements
H226 Flammable liquid and vapour
H302 Harmful if swallowed
H373 May cause damage to organs through prolonged or repeated exposure
H351 Suspected of causing cancer
H336 May cause drowsiness or dizziness
H304 May be fatal if swallowed and enters airways
H260 In contact with water releases flammable gases which may ignite spontaneously
H314 Causes severe skin burns and eye damage
H261 In contact with water releases flammable gas
H225 Highly Flammable liquid and vapour
H320 Causes eye irritation
H315 Causes skin irritation
H372 Causes damage to organs through prolonged or repeated exposure
H371 May cause damage to organs
H335 May cause respiratory irritation
H318 Causes serious eye damage
Substance
- Product name: Methylmagnesium Bromide
- Synonyms: MeMgBr,Methylmagnesium Bromide
- CAS: 75-16-1
- EC number: 200-844-1
- MF: CH3BrMg
- MW: 119.24
4.1 Description of first-aid measures
General adviceFirst aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaCarbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
Water Foam
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Hydrogen bromide gas
Magnesium oxide
Mixture with combustible ingredients.
Vapors are heavier than air and may spread along floors.
May not get in touch with: Water
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
Hydrogen bromide gas
Magnesium oxide
Mixture with combustible ingredients.
Vapors are heavier than air and may spread along floors.
May not get in touch with: Water
Forms explosive mixtures with air at elevated temperatures.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
3
4
2
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 4 | Will rapidly or completely vaporize at normal atmospheric pressure and temperature, or is readily dispersed in air and will burn readily. Includes pyrophoric substances. Flash point below room temperature at 22.8 °C (73 °F). (e.g. acetylene, propane, hydrogen gas) | |
| REACT | 2 | Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingKeep workplace dry. Do not allow product to come into contact with water.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Keep away from heat and sources of ignition.
Never allow product to get in contact with water during storage.
Handle and store under inert gas.
Storage class
Never allow product to get in contact with water during storage.
Handle and store under inert gas.
Storage class (TRGS 510): 4.3: Hazardous materials, which set free flammable gases upon contact with water
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
required
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorPale brown
- c) OdorNo data available
- d) Melting point/freezing pointNo data available
- e) Initial boiling point and boiling range78-80℃
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point28 °C - closed cup - ASTM D 93
- i) Autoignition temperatureThe substance or mixture is not classified as pyrophoric.
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityReacts with water.
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density0.856 g/cm3
- Relative density1.035 g/mL at 25 °C
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNot classified as explosive.
- t) Oxidizing propertiesnone
9.2 Other safety information
No data available
10.1 Chemical stability
sensitive to moisture
10.2 Possibility of hazardous reactions
No data available
10.3 Conditions to avoid
Heating.
Moisture.
Moisture.
10.4 Incompatible materials
Oxidizing agents, Strong acids, Oxygen, Alcohols, acids, Reacts violently with water.
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Mixture Acute toxicitySymptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Inhalation: No data available
Dermal: No data available
Remarks: Mixture causes burns.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Risk of blindness!
Respiratory or skin sensitization
Risk of blindness!
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Components 1,1'-Oxybis(butane)
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Acute toxicity
LD50 Oral - Rat - male - 7,400 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - male - 4 h - 21.6 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - 7,741 mg/kg (OECD Test Guideline 402)
LC50 Inhalation - Rat - male - 4 h - 21.6 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - 7,741 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Mild skin irritation - 4 h (OECD Test Guideline 404)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Remarks: Drying-out effect resulting in rough and chapped skin.
Dermatitis
Result: Mild skin irritation - 4 h (OECD Test Guideline 404)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Remarks: Drying-out effect resulting in rough and chapped skin.
Dermatitis
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Moderate eye irritation (OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Result: Moderate eye irritation (OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Respiratory or skin sensitization
Open epicutaneous test - Guinea pig
Result: negative (OECD Test Guideline 406)
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Human lymphocytes
Result: negative
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Human lymphocytes
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Methylmagnesium bromide Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Inhalation: No data available
Dermal: No data available
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
12.1 Toxicity
MixtureNo data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
Components 1,1'-Oxybis(butane)
Toxicity to fish flow-through test LC50 - Pimephales promelas (fathead minnow) - 32.3 mg/l - 96 h (OECD Test Guideline 203)
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - > 18.76 and other aquatic mg/l - 48 h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - ca. 19.1 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1,000 mg/l - 30 min (OECD Test Guideline 209)
Remarks: (above the solubility limit in the test medium)
Methylmagnesium bromide
Toxicity to daphnia semi-static test EC50 - Daphnia magna (Water flea) - > 18.76 and other aquatic mg/l - 48 h invertebrates (OECD Test Guideline 202)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - ca. 19.1 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1,000 mg/l - 30 min (OECD Test Guideline 209)
Remarks: (above the solubility limit in the test medium)
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 3399
IMDG: 3399
IATA-DGR: 3399
IMDG: 3399
IATA-DGR: 3399
14.2 UN proper shipping name
ADR/RID: ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE (1,1'-Oxybis(butane), Methylmagnesium bromide)
IMDG: ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE (Methylmagnesium bromide, 1,1'-Oxybis(butane))
IATA-DGR: Organometallic substance, liquid, water-reactive, flammable (Methylmagnesium bromide, 1,1'-Oxybis(butane))
Passenger Aircraft: Not permitted for transport
IMDG: ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE (Methylmagnesium bromide, 1,1'-Oxybis(butane))
IATA-DGR: Organometallic substance, liquid, water-reactive, flammable (Methylmagnesium bromide, 1,1'-Oxybis(butane))
Passenger Aircraft: Not permitted for transport
14.3 Transport hazard class(es)
ADR/RID: 4.3 (3)
IMDG: 4.3 (3)
IATA-DGR: 4.3 (3)
IMDG: 4.3 (3)
IATA-DGR: 4.3 (3)
14.4 Packaging group
ADR/RID: I
IMDG: I
IATA-DGR: I
IMDG: I
IATA-DGR: I
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
Oxidizing agents, Strong acids, Oxygen, Alcohols, acids, Reacts violently with water.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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