Chemical Safety Data Sheet MSDS / SDS

N,N-Dimethylacetamide

Revision Date:2024-06-15Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: N,N-Dimethylacetamide
  • CBnumber: CB8853004
  • CAS: 127-19-5
  • EINECS Number: 204-826-4
  • Synonyms: DMAc,N,N-dimethylacetamide

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P501 Dispose of contents/container to..…
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P271 Use only outdoors or in a well-ventilated area.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P264 Wash hands thoroughly after handling.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P202 Do not handle until all safety precautions have been read and understood.
P201 Obtain special instructions before use.
Hazard statements
H373 May cause damage to organs through prolonged or repeated exposure
H372 Causes damage to organs through prolonged or repeated exposure
H360 May damage fertility or the unborn child
H351 Suspected of causing cancer
H336 May cause drowsiness or dizziness
H332 Harmful if inhaled
H320 Causes eye irritation
H319 Causes serious eye irritation
H312 Harmful in contact with skin
H227 Combustible liquid
Disposal
WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/nn-dimethylacetamide

SECTION 3: Composition/information on ingredients

Substance

  • Product name: N,N-Dimethylacetamide
  • Synonyms: DMAc,N,N-dimethylacetamide
  • CAS: 127-19-5
  • EC number: 204-826-4
  • MF: C4H9NO
  • MW: 87.12

SECTION 4: First aid measures

Description of first aid measures

General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Carbon dioxide (CO2) Foam Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx) Combustible.

Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating.

Development of hazardous combustion gases or vapours possible in the event of fire. Risk of dust explosion.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

2
2
0
HEALTH 2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE 2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Store under inert gas. Hygroscopic.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment
Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Body Protection

protective clothing

Respiratory protection

Recommended Filter type: Filter A-(P3)

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

Exposure limits
NIOSH REL: TWA 10 ppm (35 mg/m3), IDLH 300 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancecolorless liquid, clear
  • OdourAmmonia odor
  • Odour Threshold44,4 ppm
  • pHca.4 at 200 g/l at 20 °C
  • Melting point/freezing pointMelting point/range: -20 °C
  • Initial boiling point and boiling range164,5 - 166 °C
  • Flash point64 °C - closed cup
  • Evaporation rateNo data available
  • Flammability (solid, gas)No data available
  • Upper/lower flammability or explosive limits Upper explosion limit: 11,5 %(V) Lower explosion limit: 1,8 %(V)
  • Vapour pressure 2 hPa at 21,7 °C
  • Vapour density 3,01 - (Air = 1.0)
  • Relative density0,937 g/mL at 25 °C No data available
  • Water solubility1.000 g/l at 20 °C - completely miscible
  • Partition coefficient: n-octanol/waterlog Pow: -0,77 - Bioaccumulation is not expected., (Lit.)
  • Autoignition temperature 345 °C at 999 - 1.011 hPa - DIN 51794
  • Decomposition temperature No data available
  • ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 0,92 mPa.s at 25 °C
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available
  • λmaxλ: 270 nm Amax: 1.00
    λ: 280 nm Amax: 0.30
    λ: 290 nm Amax: 0.15
    λ: 310 nm Amax: 0.05
    λ: 320 nm Amax: 0.03
    λ: 360-400 nm Amax: 0.01

Other safety information

Dissociation constant -0,19 at 25 °C


Relative vapor density

3,01 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Forms explosive mixtures with air on intense heating.

A range from approx. 15 Kelvin below the flash point is to be rated as critical.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) . hygroscopic

Possibility of hazardous reactions

No data available

Conditions to avoid

Strong heating.

Incompatible materials

various plastics

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and
gastrointestinal tract.
LC50 Inhalation - Rat - female - 1 h - 8,8 mg/l (OECD Test Guideline 403)
Remarks: (ECHA)
Acute toxicity estimate Dermal - 1.100,1 mg/kg (Expert judgment)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Irritating to eyes. (OECD Test Guideline 405)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Guinea pig Result: negative
(OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Human lymphocytes
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: negative
Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Carcinogenicity
No data available
Reproductive toxicity
May damage the unborn child.
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Toxicity
LD50 orally in rats: 5.4 ml/kg (Bartsch)

SECTION 12: Ecological information

Toxicity

Toxicity to fish
static test LC50 - Leuciscus idus (Golden orfe) - > 500 mg/l - 96 h (DIN 38412 T15)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - > 500 mg/l - 48 h (Regulation (EC) No. 440/2008, Annex, C.2)

Toxicity to algae
static test ErC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 72 h

(DIN 38412)

Toxicity to bacteria
static test EC10 - activated sludge - > 1.995 mg/l - 30 min (OECD Test Guideline 209)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 70 % - Readily biodegradable. (OECD Test Guideline 301C)

Remarks: The 10 day time window criterion is not fulfilled.


Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Incompatibilities

Dimethylacetamide is incompatible with carbon tetrachloride, oxidizing agents, halogenated compounds, and iron. It attacks plastic and rubber. Contact with strong oxidizers may cause fire.

SECTION 14: Transport information

UN number

ADR/RID: - IMDG: - IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

Packaging group

ADR/RID: - IMDG: - IATA: -

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
EC Inventory:Listed.
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.There is no odour warning even when toxic concentrations are present.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

Recommended Products
N,N-Dimethylcyclohexylamine SDS 2-Chloro-N,N-dimethylacetamide SDS Acetamide SDS Folic acid SDS 1-Phenyl-2-pyrrolidinone SDS N,N-DIMETHYL-M-TOLUIDINE SDS Dimethyl sulfoxide SDS 1,1-Dimethoxy-N,N-dimethylethylamine SDS N,N-Dimethylacetamide SDS Dimethyl carbonate SDS